Ascorbic Acid 50-81-7 API MANUFACTURER EXPORTER MEDIOCON INC

 

   Ascorbic Acid  Manufactured by Mediocon Inc     

 

·   Name:  Ascorbic Acid  Manufactured by Mediocon Inc   

 

·   CAS No: 50-81-7

 

·   Molecular Weight: 176.12g/mol

 

·   Molecular formula: C₆H₈O₆

 

·   Synonyms: Vitamin C.

·    Chemical structure:

                                                         

 

                                                               

·   Appearance:

White to pale yellow crystals or powder

·   Solubility:

 It dissolves freely in water to give mildly acidic solutions.

·   Use :

 

Nutritional Supplement

1. Vitamin C deficiency:  Ascorbic Acid  Manufactured by Mediocon Inc    is used to treat vitamin C deficiency, which can cause scurvy, fatigue, and weakened immune function.

2. Immune system support:  Ascorbic Acid  Manufactured by Mediocon Inc    helps boost the immune system, reducing the severity of colds and flu.

 

Antioxidant Properties

1. Free radical scavenger:  Ascorbic Acid  Manufactured by Mediocon Inc    neutralizes free radicals, which can damage cells and contribute to chronic diseases like cancer, diabetes, and heart disease.

2. Anti-aging: Ascorbic acid's antioxidant properties help reduce oxidative stress, promoting healthy aging and reducing the appearance of fine lines and wrinkles.

 

Medical Conditions

1. Cardiovascular health:  Ascorbic Acid  Manufactured by Mediocon Inc    helps lower blood pressure, improve blood vessel function, and reduce the risk of heart disease.

2. Cancer treatment:  Ascorbic Acid  Manufactured by Mediocon Inc    may be used as an adjunct therapy to enhance the effectiveness of cancer treatments and reduce side effects.

3. Wound healing:  Ascorbic Acid  Manufactured by Mediocon Inc    is essential for collagen synthesis, promoting wound healing and tissue repair.

 

Skin, Hair, and Nail Health

1. Skin brightening: Ascorbic acid's antioxidant properties help reduce melanin production, promoting a brighter, more even-toned complexion.

2. Hair growth:  Ascorbic Acid  Manufactured by Mediocon Inc    helps promote hair growth by enhancing collagen production and improving circulation to the scalp.

3. Nail health:  Ascorbic Acid  Manufactured by Mediocon Inc    helps strengthen brittle nails and promote healthy nail growth.

 

Food and Beverage Industry

1. Food preservation:  Ascorbic Acid  Manufactured by Mediocon Inc    is used as a natural preservative to extend the shelf life of food products.

2. Flavor enhancement:  Ascorbic Acid  Manufactured by Mediocon Inc    is used to enhance the flavor and aroma of food products.

 

Pharmaceutical Applications

1. Tablets and capsules:  Ascorbic Acid  Manufactured by Mediocon Inc    is available in oral tablets and capsules, typically in doses ranging from 500 mg to 2,000 mg.

2. Injectable solutions:  Ascorbic Acid  Manufactured by Mediocon Inc    is also available in injectable solutions, typically used for severe vitamin C deficiency or for individuals who have difficulty absorbing vitamin C from oral supplements.

3. Topical creams and gels:  Ascorbic Acid  Manufactured by Mediocon Inc    is available in topical creams and gels, used to promote skin health and reduce the appearance of fine lines and wrinkles.

Skincare and Cosmetics

1. Anti-aging:  Ascorbic Acid  Manufactured by Mediocon Inc    reduces fine lines, wrinkles, and skin discoloration, promoting a smoother, more youthful appearance.

2. Acne treatment:  Ascorbic Acid  Manufactured by Mediocon Inc    helps unclog pores, reduce inflammation, and prevent future breakouts.

3. Skin brightening:  Ascorbic Acid  Manufactured by Mediocon Inc    fades age spots, hyper pigmentation, and uneven skin tone.

4. Skin texture improvement:  Ascorbic Acid  Manufactured by Mediocon Inc    enhances skin elasticity, firmness, and texture.

Medical Applications

1. Acne vulgaris treatment:  Ascorbic Acid  Manufactured by Mediocon Inc    is prescribed to treat moderate to severe acne.

2. Psoriasis treatment:  Ascorbic Acid  Manufactured by Mediocon Inc    helps reduce scaling, inflammation, and skin cell proliferation.

3. Skin cancer prevention:  Ascorbic Acid  Manufactured by Mediocon Inc    may help prevent skin cancer by promoting cell differentiation and reducing tumor growth.

4. Wound healing:  Ascorbic Acid  Manufactured by Mediocon Inc    enhances wound healing by promoting collagen synthesis and tissue regeneration.

Pharmaceutical Applications

1. Vitamin A deficiency treatment:  Ascorbic Acid  Manufactured by Mediocon Inc    is used to treat vitamin A deficiency, which can cause night blindness, impaired immune function, and skin problems.

2. Cancer treatment:  Ascorbic Acid  Manufactured by Mediocon Inc    is being researched as a potential adjunct therapy for certain types of cancer, such as breast, lung, and prostate cancer.

Food and Beverage Applications

1. Fortification:  Ascorbic Acid  Manufactured by Mediocon Inc    is added to foods, such as milk, cereals, and energy bars, to enhance their nutritional value.

2. Dietary supplements:  Ascorbic Acid  Manufactured by Mediocon Inc    is available as a dietary supplement in various forms, including capsules, tablets, and oils.

Research Applications

1. Cell biology research:  Ascorbic Acid  Manufactured by Mediocon Inc    is used in cell culture studies to investigate cellular differentiation, proliferation, and apoptosis.

2. Cancer research:  Ascorbic Acid  Manufactured by Mediocon Inc    is being researched for its potential anti-cancer properties and its role in cancer prevention and treatment.

·      How is  Ascorbic Acid  Manufactured by Mediocon Inc    Synthesized?

 

Chemical Synthesis

1. Reichstein process: This is a multi-step process that involves the conversion of glucose to sorbose, followed by the conversion of sorbose to ascorbic acid.

2. Hoffmann-La Roche process: This process involves the conversion of glucose to 2-keto-L-gulonic acid, followed by the conversion of 2-keto-L-gulonic acid to ascorbic acid.

 

Microbial Fermentation

1. Fermentation of glucose: Microorganisms such as Gluconobacter oxydans or Erwinia herbicola are used to ferment glucose to produce ascorbic acid.

2. Fermentation of sorbose: Microorganisms such as Acetobacter suboxydans or Gluconobacter oxydans are used to ferment sorbose to produce ascorbic acid.

 

Enzymatic Synthesis

1. Enzymatic conversion of glucose: Enzymes such as glucose oxidase or gluconate dehydrogenase are used to convert glucose to gluconic acid, which is then converted to ascorbic acid.

2. Enzymatic conversion of sorbose: Enzymes such as sorbose dehydrogenase or gluconate dehydrogenase are used to convert sorbose to ascorbic acid.

 

Biotechnological Methods

1. Genetic engineering: Microorganisms such as Escherichia coli or Saccharomyces cerevisiae are genetically engineered to produce ascorbic acid.

2. Fermentation of genetically engineered microorganisms: Genetically engineered microorganisms are fermented to produce ascorbic acid.

 

 

 

 

 

·   What are the different dosage forms of  Ascorbic Acid  Manufactured by Mediocon Inc    ?

Oral Dosage Forms

1. Tablets: Available in various strengths, ranging from 50 mg to 1,000 mg per tablet.

2. Capsules: Available in various strengths, ranging from 50 mg to 1,000 mg per capsule.

3. Powder: Available in various strengths, ranging from 50 mg to 1,000 mg per serving.

4. Gummies: Available in various strengths, ranging from 50 mg to 1,000 mg per gummy.

5. Lozenges: Available in various strengths, ranging from 50 mg to 1,000 mg per lozenge.

 

Topical Dosage Forms

1. Creams: Available in various strengths, ranging from 5% to 20% ascorbic acid.

2. Gels: Available in various strengths, ranging from 5% to 20% ascorbic acid.

3. Solutions: Available in various strengths, ranging from 5% to 20% ascorbic acid.

4. Serums: Available in various strengths, ranging from 5% to 20% ascorbic acid.

 

Injectable Dosage Forms

1. Ampules: Available in various strengths, ranging from 100 mg to 1,000 mg per ampule.

2. Vials: Available in various strengths, ranging from 100 mg to 1,000 mg per vial.

 

Other Dosage Forms

1. Chewable tablets: Available in various strengths, ranging from 50 mg to 1,000 mg per tablet.

2. Effervescent tablets: Available in various strengths, ranging from 50 mg to 1,000 mg per tablet.

3. Liquid solutions: Available in various strengths, ranging from 50 mg to 1,000 mg per serving.

 

Combination Dosage Forms

1. Multivitamin tablets:  Ascorbic Acid  Manufactured by Mediocon Inc    is often combined with other vitamins and minerals in multivitamin tablets.

2. Vitamin C and bioflavonoid combinations:  Ascorbic Acid  Manufactured by Mediocon Inc    is often combined with bioflavonoids, such as rutin and hesperidin, to enhance its absorption and efficacy.

 

·         How  Ascorbic Acid  Manufactured by Mediocon Inc    Dosage Forms are prepared?

 Ascorbic Acid  Manufactured by Mediocon Inc    dosage forms are prepared using various methods, including:

Tablet Preparation

1. Weighing and mixing:  Ascorbic Acid  Manufactured by Mediocon Inc    powder is weighed and mixed with other ingredients, such as fillers, binders, and lubricants.

2. Granulation: The mixture is granulated to form a uniform blend.

3. Tablet compression: The granules are compressed into tablets using a tablet press.

4. Coating: The tablets may be coated with a layer of material, such as wax or shellac, to protect the  Ascorbic Acid  Manufactured by Mediocon Inc    from degradation.

Capsule Preparation

1. Weighing and mixing:  Ascorbic Acid  Manufactured by Mediocon Inc    powder is weighed and mixed with other ingredients, such as fillers and lubricants.

2. Filling: The mixture is filled into empty capsules, typically made of gelatin or vegetable-based materials.

3. Sealing: The capsules are sealed using a capsule sealing machine.

Powder Preparation

1. Weighing and mixing:  Ascorbic Acid  Manufactured by Mediocon Inc    powder is weighed and mixed with other ingredients, such as fillers and flavorings.

2. Blending: The mixture is blended to form a uniform powder.

3. Packaging: The powder is packaged in containers, such as bottles or sachets.

Liquid Preparation

1. Weighing and mixing:  Ascorbic Acid  Manufactured by Mediocon Inc    powder is weighed and mixed with other ingredients, such as water, flavorings, and preservatives.

2. Dissolution: The mixture is dissolved to form a uniform solution.

3. Filtration: The solution may be filtered to remove impurities.

4. Packaging: The liquid is packaged in containers, such as bottles or vials.

Topical Preparation

1. Weighing and mixing:  Ascorbic Acid  Manufactured by Mediocon Inc    powder is weighed and mixed with other ingredients, such as creams, gels, or ointments.

2. Blending: The mixture is blended to form a uniform topical preparation.

3. Packaging: The topical preparation is packaged in containers, such as tubes or jars.

Injectable Preparation

1. Weighing and mixing:  Ascorbic Acid  Manufactured by Mediocon Inc    powder is weighed and mixed with other ingredients, such as water and preservatives.

2. Dissolution: The mixture is dissolved to form a uniform solution.

3. Filtration: The solution may be filtered to remove impurities.

4. Packaging: The injectable solution is packaged in containers, such as vials or ampules.

Quality Control

1. Testing: The final product is tested for quality, purity, and potency.

2. Inspection: The final product is inspected for appearance, texture, and packaging.

3. Release: The final product is released for distribution and sale after passing quality control tests.

 

·         What are the appropriate Dosage forms of Ascorbic Acid?

Oral Dosage Forms

1. Tablets: 50-1000 mg per tablet, suitable for adults and children above 6 years.

2. Capsules: 50-1000 mg per capsule, suitable for adults and children above 6 years.

3. Powder: 50-1000 mg per serving, suitable for adults and children above 6 years.

4. Gummies: 25-100 mg per gummy, suitable for children and adults who have difficulty swallowing tablets or capsules.

5. Lozenges: 25-100 mg per lozenge, suitable for sore throat and cough relief.

Topical Dosage Forms

1. Creams: 5-20% Ascorbic Acid, suitable for skin care and wound healing.

2. Gels: 5-20% Ascorbic Acid, suitable for skin care and wound healing.

3. Solutions: 5-20% Ascorbic Acid, suitable for skin care and wound healing.

4. Serums: 10-30% Ascorbic Acid, suitable for skin care and anti-aging.

Injectable Dosage Forms

1. Ampules: 100-1000 mg per ampule, suitable for severe Vitamin C deficiency or medical emergencies.

2. Vials: 100-1000 mg per vial, suitable for severe Vitamin C deficiency or medical emergencies.

Pediatric Dosage Forms

1. Drops: 25-50 mg per drop, suitable for infants and young children.

2. Syrups: 25-50 mg per 5 mL, suitable for children who have difficulty swallowing tablets or capsules.

 

Geriatric Dosage Forms

1. Tablets: 50-500 mg per tablet, suitable for elderly adults who may have difficulty swallowing larger tablets.

2. Capsules: 50-500 mg per capsule, suitable for elderly adults who may have difficulty swallowing larger tablets.

 

·         When should  Ascorbic Acid  Manufactured by Mediocon Inc    be taken?

 Ascorbic Acid  Manufactured by Mediocon Inc    can be taken at different times depending on the specific product, skin type, and concerns. Here are some general guidelines:

Topical Ascorbic Acid

1. At night: Apply topical  Ascorbic Acid  Manufactured by Mediocon Inc    products at night, as they can make the skin more sensitive to the sun.

2. Before bedtime: Apply topical  Ascorbic Acid  Manufactured by Mediocon Inc    products 30 minutes to 1 hour before bedtime to allow the product to absorb into the skin.

Oral Retinol

1. With meals: Take oral  Ascorbic Acid  Manufactured by Mediocon Inc    supplements with meals to enhance absorption and reduce gastrointestinal side effects.

2. At bedtime: Take oral  Ascorbic Acid  Manufactured by Mediocon Inc    supplements at bedtime, as they can cause drowsiness.

Specific Timing Considerations

1. Avoid peak sun hours: Avoid applying topical  Ascorbic Acid  Manufactured by Mediocon Inc    products during peak sun hours (10am-4pm) to minimize photosensitivity.

2. Wait after exfoliating: Wait 24-48 hours after exfoliating or using harsh skincare products before applying topical  Ascorbic Acid  Manufactured by Mediocon Inc    products.

3. Avoid using with other exfoliants: Avoid using topical  Ascorbic Acid  Manufactured by Mediocon Inc    products with other exfoliants, such as alpha-hydroxy acids (AHAs) or beta-hydroxy acids (BHAs), as this can increase the risk of irritation.

Frequency of Application

1. Start with lower frequency: Start with a lower frequency of application (every other day) and gradually increase as your skin becomes more tolerant.

2. Adjust frequency based on skin response: Adjust the frequency of application based on your skin's response to the product.

Note: Always consult with a healthcare professional or a qualified expert before using  Ascorbic Acid  Manufactured by Mediocon Inc    products, especially if you have sensitive skin or are prone to irritation.

·         What are the effects And Side effects of Ascorbic Acid?

Positive Effects of Ascorbic Acid:

1. Boosts immune system:  Ascorbic Acid  Manufactured by Mediocon Inc    helps to support the immune system, reducing the severity of colds and flu.

2. Antioxidant properties: Ascorbic acid's antioxidant properties help to protect cells from damage caused by free radicals.

3. Improves skin health:  Ascorbic Acid  Manufactured by Mediocon Inc    helps to improve skin health, reducing the appearance of fine lines and wrinkles.

4. Supports collagen production:  Ascorbic Acid  Manufactured by Mediocon Inc    is essential for collagen production, which helps to maintain healthy skin, bones, and connective tissue.

5. Enhances iron absorption:  Ascorbic Acid  Manufactured by Mediocon Inc    helps to enhance iron absorption, reducing the risk of iron deficiency anemia.

Common Side Effects of Ascorbic Acid:

1. Gastrointestinal upset:  Ascorbic Acid  Manufactured by Mediocon Inc    can cause gastrointestinal upset, including diarrhea, nausea, and stomach cramps.

2. Heartburn:  Ascorbic Acid  Manufactured by Mediocon Inc    can cause heartburn and acid reflux in some individuals.

3. Headaches:  Ascorbic Acid  Manufactured by Mediocon Inc    can cause headaches in some individuals, particularly when taken in high doses.

4. Fatigue:  Ascorbic Acid  Manufactured by Mediocon Inc    can cause fatigue in some individuals, particularly when taken in high doses.

5. Allergic reactions: Rarely,  Ascorbic Acid  Manufactured by Mediocon Inc    can cause allergic reactions, including hives, itching, and swelling.

Rare but Serious Side Effects of Ascorbic Acid:

1. Kidney stones: High doses of  Ascorbic Acid  Manufactured by Mediocon Inc    can increase the risk of kidney stones.

2. Interference with medical tests:  Ascorbic Acid  Manufactured by Mediocon Inc    can interfere with certain medical tests, including blood glucose tests and stool tests.

3. Interaction with medications:  Ascorbic Acid  Manufactured by Mediocon Inc    can interact with certain medications, including blood thinners, and decrease their effectiveness.

Precautions and Contraindications:

1. Pregnancy and breastfeeding:  Ascorbic Acid  Manufactured by Mediocon Inc    is generally considered safe during pregnancy and breastfeeding, but high doses should be avoided.

2. Kidney disease: Individuals with kidney disease should consult with their healthcare provider before taking ascorbic acid.

3. Gastrointestinal disorders: Individuals with gastrointestinal disorders, such as ulcers or inflammatory bowel disease, should consult with their healthcare provider before taking ascorbic acid.

Recommended Dosage:

1. Adults: 60-90 mg per day.

2. Pregnant women: 80-85 mg per day.

3. Breastfeeding women: 120 mg per day.

4. Children: 15-45 mg per day, depending on age.

 

 

 

 

·         How is  Ascorbic Acid  Manufactured by Mediocon Inc    Tested Qualitatively?

 Ascorbic Acid  Manufactured by Mediocon Inc    can be tested qualitatively using various methods to detect its presence and identify its structure:

Chemical Tests

1. Carr-Price test: A colorimetric test that uses antimony trichloride to produce a blue color in the presence of retinol.

2. SbCl3 test: A colorimetric test that uses antimony trichloride to produce a blue color in the presence of retinol.

3. Trichloroacetic acid test: A precipitation test that uses trichloroacetic acid to precipitate retinol.

Spectroscopic Tests

1. Ultraviolet (UV) spectroscopy:  Ascorbic Acid  Manufactured by Mediocon Inc    exhibits a characteristic UV absorption spectrum with maxima at 325-330 nm.

2. Infrared (IR) spectroscopy:  Ascorbic Acid  Manufactured by Mediocon Inc    exhibits a characteristic IR absorption spectrum with peaks at 1600-1700 cm-1 (C=C stretching) and 1100-1200 cm-1 (C-O stretching).

3. Nuclear Magnetic Resonance (NMR) spectroscopy:  Ascorbic Acid  Manufactured by Mediocon Inc    exhibits a characteristic NMR spectrum with signals at 4-6 ppm (olefinic protons) and 2-3 ppm (allylic protons).

Chromatographic Tests

1. Thin Layer Chromatography (TLC):  Ascorbic Acid  Manufactured by Mediocon Inc    can be separated and identified using TLC with a suitable solvent system.

2. High Performance Liquid Chromatography (HPLC):  Ascorbic Acid  Manufactured by Mediocon Inc    can be separated and identified using HPLC with a suitable column and solvent system.

Biological Tests

1. Vitamin A activity test:  Ascorbic Acid  Manufactured by Mediocon Inc    can be tested for its vitamin A activity using biological assays, such as the rat growth assay.

2. Anti-keratinization test:  Ascorbic Acid  Manufactured by Mediocon Inc    can be tested for its ability to inhibit keratinization using cell culture assays.

Note: These tests may require specialized equipment, expertise, and reagents. Always consult with a qualified expert or follow established protocols when testing  Ascorbic Acid  Manufactured by Mediocon Inc    qualitatively.

 

·         Which tests are performed on Ascorbic Acid?

Physical Tests

1. Appearance: Visual inspection to check the color, texture, and appearance of ascorbic acid.

2. Odor: Olfactory inspection to check the characteristic odor of ascorbic acid.

3. Melting point: Determination of the melting point of  Ascorbic Acid  Manufactured by Mediocon Inc    to check its purity.

4. Solubility: Testing of ascorbic acid's solubility in various solvents, such as water, ethanol, and methanol.

Chemical Tests

1. Assay: Quantitative determination of ascorbic acid's potency using various analytical techniques, such as HPLC or UV spectroscopy.

2. Impurities: Testing for impurities, such as heavy metals, pesticides, and other contaminants.

3. pH: Determination of the pH of  Ascorbic Acid  Manufactured by Mediocon Inc    solutions to check their acidity or alkalinity.

4. Stability: Testing of ascorbic acid's stability under various conditions, such as temperature, humidity, and light.

Spectroscopic Tests

1. Infrared (IR) spectroscopy: Identification of ascorbic acid's characteristic IR absorption peaks.

2. Ultraviolet (UV) spectroscopy: Determination of ascorbic acid's UV absorption spectrum.

3. Nuclear Magnetic Resonance (NMR) spectroscopy: Structural elucidation of  Ascorbic Acid  Manufactured by Mediocon Inc    using NMR spectroscopy.

Chromatographic Tests

1. Thin-layer chromatography (TLC): Separation and identification of  Ascorbic Acid  Manufactured by Mediocon Inc    using TLC.

2. High-performance liquid chromatography (HPLC): Quantitative determination of ascorbic acid's potency using HPLC.

3. Gas chromatography (GC): Separation and identification of  Ascorbic Acid  Manufactured by Mediocon Inc    using GC.

Microbiological Tests

1. Sterility testing: Testing for the presence of microorganisms in  Ascorbic Acid  Manufactured by Mediocon Inc    samples.

2. Endotoxin testing: Testing for the presence of endotoxins in  Ascorbic Acid  Manufactured by Mediocon Inc    samples.

Other Tests

1. Heavy metal testing: Testing for the presence of heavy metals, such as lead, mercury, and arsenic.

2. Pesticide testing: Testing for the presence of pesticides and other contaminants.

3. Label claim verification: Verification of ascorbic acid's label claims, such as its potency and purity.

 

·         What are the challenges in Manufacturing Of  Ascorbic Acid  Manufactured by Mediocon Inc    API?

Fermentation Process Challenges

1. Microorganism selection: Selecting the right microorganism for fermentation, such as Gluconobacter oxydans or Erwinia herbicola, can be challenging.

2. Fermentation conditions: Optimizing fermentation conditions, such as temperature, pH, and nutrient levels, can be difficult.

3. Scalability: Scaling up fermentation processes while maintaining consistency and quality can be a challenge.

 

Chemical Synthesis Challenges

1. Raw material quality: Ensuring the quality of raw materials, such as glucose or sorbose, can be challenging.

2. Reaction conditions: Optimizing reaction conditions, such as temperature, pressure, and catalysts, can be difficult.

3. Yield and purity: Achieving high yields and purity of  Ascorbic Acid  Manufactured by Mediocon Inc    can be a challenge.

Purification and Isolation Challenges

1. Impurity removal: Removing impurities, such as heavy metals, pesticides, and other contaminants, can be challenging.

2. Crystallization: Crystallizing  Ascorbic Acid  Manufactured by Mediocon Inc    to achieve the desired polymorphic form can be difficult.

3. Drying and packaging: Drying and packaging  Ascorbic Acid  Manufactured by Mediocon Inc    API to prevent degradation and contamination can be a challenge.

Quality Control and Assurance Challenges

1. Testing and validation: Testing and validating  Ascorbic Acid  Manufactured by Mediocon Inc    API to ensure compliance with regulatory requirements can be challenging.

2. Stability testing: Conducting stability testing to ensure the shelf-life of  Ascorbic Acid  Manufactured by Mediocon Inc    API can be a challenge.

3. Regulatory compliance: Complying with regulatory requirements, such as cGMP and ICH guidelines, can be a challenge.

Environmental and Safety Challenges

1. Waste management: Managing waste generated during  Ascorbic Acid  Manufactured by Mediocon Inc    production, such as fermentation broths and chemical waste, can be challenging.

2. Occupational safety: Ensuring the safety of personnel handling  Ascorbic Acid  Manufactured by Mediocon Inc    API and intermediates can be a concern.

3. Environmental impact: Minimizing the environmental impact of  Ascorbic Acid  Manufactured by Mediocon Inc    production can be a challenge.

Economic Challenges

1. Cost of raw materials: The cost of raw materials, such as glucose or sorbose, can fluctuate and impact production costs.

2. Energy and utility costs: Energy and utility costs, such as electricity and water, can impact production costs.

3. Competition and market demand: Competition and market demand can impact the profitability of  Ascorbic Acid  Manufactured by Mediocon Inc    production.

 

 

·         What are the challenges in manufacturing of  Ascorbic Acid  Manufactured by Mediocon Inc    Dosage forms?

Tablet Manufacturing Challenges

1. Stability:  Ascorbic Acid  Manufactured by Mediocon Inc    is prone to degradation, especially when exposed to moisture, heat, and light.

2. Compression:  Ascorbic Acid  Manufactured by Mediocon Inc    tablets can be difficult to compress due to their hygroscopic nature.

3. Disintegration: Ensuring consistent disintegration times for  Ascorbic Acid  Manufactured by Mediocon Inc    tablets can be challenging.

Capsule Manufacturing Challenges

1. Fill weight variation: Ensuring consistent fill weights for  Ascorbic Acid  Manufactured by Mediocon Inc    capsules can be challenging.

2. Moisture control:  Ascorbic Acid  Manufactured by Mediocon Inc    capsules require careful moisture control to prevent degradation.

3. Capsule shell integrity: Ensuring the integrity of the capsule shell to prevent leakage or breakage can be challenging.

Liquid Manufacturing Challenges

1. Solubility:  Ascorbic Acid  Manufactured by Mediocon Inc    has limited solubility in water, making it challenging to formulate liquid dosage forms.

2. Stability:  Ascorbic Acid  Manufactured by Mediocon Inc    liquids can be prone to degradation, especially when exposed to light, heat, or oxygen.

3. Preservation: Ensuring the preservation of  Ascorbic Acid  Manufactured by Mediocon Inc    liquids to prevent microbial growth can be challenging.

Topical Manufacturing Challenges

1. Skin penetration: Ensuring consistent skin penetration of  Ascorbic Acid  Manufactured by Mediocon Inc    from topical dosage forms can be challenging.

2. Stability:  Ascorbic Acid  Manufactured by Mediocon Inc    topical dosage forms can be prone to degradation, especially when exposed to light, heat, or oxygen.

3. Skin irritation: Ensuring that  Ascorbic Acid  Manufactured by Mediocon Inc    topical dosage forms do not cause skin irritation can be challenging.

Quality Control and Assurance Challenges

1. Testing and validation: Testing and validating  Ascorbic Acid  Manufactured by Mediocon Inc    dosage forms to ensure compliance with regulatory requirements can be challenging.

2. Stability testing: Conducting stability testing to ensure the shelf-life of  Ascorbic Acid  Manufactured by Mediocon Inc    dosage forms can be a challenge.

3. Regulatory compliance: Complying with regulatory requirements, such as cGMP and ICH guidelines, can be a challenge.

Scale-Up and Manufacturing Challenges

1. Equipment design: Designing equipment to handle ascorbic acid's hygroscopic and oxidative properties can be challenging.

2. Process optimization: Optimizing manufacturing processes to ensure consistent quality and yield can be challenging.

3. Cost control: Controlling manufacturing costs while ensuring quality and compliance can be challenging.

·         What are the storage conditions of  Ascorbic Acid  Manufactured by Mediocon Inc    ?

Storage Conditions:

1. Temperature: Store  Ascorbic Acid  Manufactured by Mediocon Inc    in a cool, dry place at a temperature between 15°C to 25°C (59°F to 77°F).

2. Humidity: Store  Ascorbic Acid  Manufactured by Mediocon Inc    in a low-humidity environment, ideally below 60% relative humidity.

3. Light: Protect  Ascorbic Acid  Manufactured by Mediocon Inc    from direct sunlight and UV light, which can cause degradation.

4. Air: Store  Ascorbic Acid  Manufactured by Mediocon Inc    in airtight containers to prevent exposure to air, which can cause oxidation.

 

Packaging Requirements:

1. Airtight containers: Store  Ascorbic Acid  Manufactured by Mediocon Inc    in airtight containers, such as glass or plastic bottles, or foil-lined bags.

2. Moisture-resistant packaging: Use moisture-resistant packaging materials, such as aluminum foil or plastic film, to prevent moisture absorption.

3. Protective coatings: Apply protective coatings, such as wax or shellac, to prevent moisture absorption and degradation.

Storage Containers:

1. Glass containers: Glass containers are suitable for storing ascorbic acid, but they should be protected from light and moisture.

2. Plastic containers: Plastic containers, such as HDPE or PET, are suitable for storing ascorbic acid, but they should be protected from light and moisture.

3. Fiber drums: Fiber drums are suitable for storing ascorbic acid, but they should be protected from moisture and light.

Handling Precautions:

1. Handle with care: Handle  Ascorbic Acid  Manufactured by Mediocon Inc    containers with care to prevent damage and moisture absorption.

2. Avoid exposure to air: Minimize exposure to air when handling  Ascorbic Acid  Manufactured by Mediocon Inc    to prevent oxidation.

3. Wear protective gear: Wear protective gear, such as gloves and goggles, when handling  Ascorbic Acid  Manufactured by Mediocon Inc    to prevent skin and eye irritation.

·         What is the Packing for Ascorbic Acid?

Primary Packaging:

1. Glass bottles: Glass bottles with tight-fitting lids are commonly used to pack ascorbic acid.

2. Plastic containers: Plastic containers, such as HDPE or PET, are also used to pack ascorbic acid.

3. Fiber drums: Fiber drums with inner liners are used to pack large quantities of ascorbic acid.

4. Aluminum foil bags: Aluminum foil bags are used to pack  Ascorbic Acid  Manufactured by Mediocon Inc    powder or granules.

Secondary Packaging:

1. Cartons: Cartons are used to pack glass bottles or plastic containers.

2. Boxes: Boxes are used to pack fiber drums or aluminum foil bags.

3. Pallets: Pallets are used to pack large quantities of ascorbic acid.

Protective Packaging:

1. Desiccants: Desiccants, such as silica gel, are used to control humidity and prevent moisture absorption.

2. Moisture-resistant packaging: Moisture-resistant packaging materials, such as aluminum foil or plastic film, are used to prevent moisture absorption.

3. Light-resistant packaging: Light-resistant packaging materials, such as amber glass or opaque plastic, are used to prevent light degradation.

Labeling and Marking:

1. Product label: A product label is attached to the container with information such as product name, batch number, and expiration date.

2. Warning labels: Warning labels are attached to the container to indicate potential hazards, such as moisture sensitivity or light sensitivity.

3. Barcodes: Barcodes are used to track inventory and ensure accurate shipping.

 

·         What is shelf life Of Ascorbic Acid? 

The shelf life of  Ascorbic Acid  Manufactured by Mediocon Inc    depends on various factors, including storage conditions, packaging, and formulation. Generally,  Ascorbic Acid  Manufactured by Mediocon Inc    is considered stable for 2-3 years when stored in a cool, dry place, away from direct sunlight and heat.¹

However, its potency may decrease over time, especially when exposed to moisture, heat, or light. A study found that 92% of vitamin C supplements showed significant losses in concentration after 12 months of storage.

To extend the shelf life of ascorbic acid, it's essential to store it properly. Here are some tips:

- Store in a cool, dry place: Avoid storing  Ascorbic Acid  Manufactured by Mediocon Inc    in humid or hot environments.

- Protect from light: Keep  Ascorbic Acid  Manufactured by Mediocon Inc    away from direct sunlight or UV light.

- Use airtight containers: Store  Ascorbic Acid  Manufactured by Mediocon Inc    in airtight containers to prevent moisture absorption.

- Refrigerate: Some formulations, like retinoids, may require refrigeration after opening.

When it comes to specific products, the shelf life may vary. For example, The Ordinary's  Ascorbic Acid  Manufactured by Mediocon Inc    products have a shelf life of 6 months after opening.² Always check the product label or manufacturer's instructions for specific guidance on storage and shelf life.

·         What should the label claim for  Ascorbic Acid  Manufactured by Mediocon Inc    Include?

 

Mandatory Information

1. Product name: The name of the product, which should include the words "Ascorbic Acid" or "Vitamin C".

2. Strength: The amount of  Ascorbic Acid  Manufactured by Mediocon Inc    per serving, expressed in milligrams (mg) or grams (g).

3. Dosage form: The physical form of the product, such as tablets, capsules, powder, or liquid.

4. Net quantity: The total amount of product in the container, expressed in weight (e.g., grams or milligrams) or volume (e.g., milliliters or liters).

Recommended Information

1. Daily value: The percentage of the Daily Value (DV) for  Ascorbic Acid  Manufactured by Mediocon Inc    per serving.

2. Ingredients: A list of all ingredients, including inactive ingredients, such as fillers, binders, and preservatives.

3. Directions for use: Instructions on how to take the product, including the recommended dosage and frequency.

4. Warnings and precautions: Any warnings or precautions related to the product, such as potential interactions with medications or allergic reactions.

5. Storage instructions: Instructions on how to store the product properly to maintain its potency and shelf life.

Optional Information

1. Expiration date or shelf life: The date by which the product should be used or the expected shelf life of the product.

2. Manufacturing information: The name and address of the manufacturer, as well as any relevant certifications, such as cGMP or ISO 9001.

3. Third-party testing: Information about any third-party testing or certifications, such as NSF International or (link unavailable)

4. Health claims: Any health claims or benefits associated with the product, such as "Antioxidant" or "Immune system support".

Regulatory Compliance

1. Compliance with FDA regulations: The label must comply with FDA regulations, including 21 CFR Part 101 (Food Labeling) and 21 CFR Part 111 (Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements).

2. Compliance with international regulations: The label must comply with international regulations, such as the European Union's Food Information to Consumers (FIC) regulation.

 

·         Where can  Ascorbic Acid  Manufactured by Mediocon Inc    are procured?

 Ascorbic Acid  Manufactured by Mediocon Inc    can be procured from various sources, depending on your location and requirements. Here are some options:

1.      For API

 MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com            

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India
Website:  www.mediocon.com 

Email id:info@mediocon.com            

 GST No: 27DHUPM2366D1ZZ

 

2.      For Dosage Forms :

 - Online Marketplaces: You can find  Ascorbic Acid  Manufactured by Mediocon Inc    products on online marketplaces like Amazon or e-       

   commerce websites specializing in pharmaceuticals or skincare products.

  - Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in             

   your area for  Ascorbic Acid  Manufactured by Mediocon Inc    products.

    Remember to ensure the quality and authenticity of the  Ascorbic Acid  Manufactured by Mediocon Inc    product, regardless of the                    

    procurement source.