Copper 7440-50-8 Manufacturer Exporter MEDIOCON INC

 

Copper  

 

·   Name: Copper  

 

·   CAS No: 7440-50-8

 

·   Molecular Weight: 63.546 u

 

·   Molecular formula: Cu

 

·   Synonyms:   Cuprum , Blister Copper .

 

                                                        

·   Appearance:  Reddish brown metal.

 

·   Solubility :  soluble in dilute acid and in ammonia with the presence of an oxidizing agent

                  

·   Use :

                                                                   

Electrical Applications:

1. Electrical wiring: Copper is an excellent conductor of electricity and is widely used for electrical wiring in buildings, homes, and electronic devices.

2. Electromagnets: Copper is used to make electromagnets, which are essential in many applications, including motors, generators, and magnetic resonance imaging (MRI) machines.

3. Electronic components: Copper is used in the production of electronic components, such as printed circuit boards (PCBs), connectors, and switches.

 

Architectural and Building Applications:

1. Roofing and cladding: Copper is used as a roofing material due to its durability, corrosion resistance, and attractive appearance.

2. Plumbing: Copper pipes are widely used for plumbing due to their resistance to corrosion and ability to withstand high water pressure.

3. Architectural features: Copper is used to create decorative features, such as domes, spires, and other architectural elements.

 

Industrial Applications:

1. Heat exchangers: Copper is used in heat exchangers due to its high thermal conductivity and corrosion resistance.

2. Chemical processing: Copper is used in chemical processing equipment, such as reactors, heat exchangers, and distillation columns.

3. Marine hardware: Copper is used in marine hardware, such as propeller shafts, fittings, and other components due to its resistance to corrosion.

 

Medical Applications:

1. Medical implants: Copper is used in medical implants, such as hip and knee replacements, due to its biocompatibility and resistance to corrosion.

2. Wound care: Copper is used in wound care products, such as dressings and bandages, due to its antimicrobial properties.

3. Medical instruments: Copper is used in medical instruments, such as surgical instruments and diagnostic equipment, due to its biocompatibility and resistance to corrosion.

 

Other Applications:

1. Coinage: Copper is used in coinage due to its durability, corrosion resistance, and attractive appearance.

2. Ammunition: Copper is used in ammunition due to its high density and ability to withstand high pressures.

3. Art and craft: Copper is used in art and craft due to its attractive appearance, durability, and versatility.

 

 

·      How is Copper  Synthesized?

Step 1: Mining and Crushing

1. Mining: Copper ores are mined from open-pit or underground mines.

2. Crushing: The extracted ore is crushed into smaller pieces to increase its surface area.

Step 2: Grinding and Flotation

1. Grinding: The crushed ore is ground into a fine powder to release the copper minerals.

2. Flotation: The powdered ore is mixed with water and surfactants, and then subjected to flotation, which separates the copper minerals from the waste rock.

Step 3: Smelting

1. Smelting: The concentrated copper minerals are heated in a furnace with a reducing agent, such as coal or natural gas, to produce a molten copper matte.

Step 4: Refining

1. Electrolysis: The copper matte is refined through electrolysis, where it's dissolved in a bath of sulfuric acid and then plated onto a cathode.

2. Fire refining: The resulting copper is then fire-refined to remove any remaining impurities.

Step 5: Casting and Rolling

1. Casting: The refined copper is cast into ingots or other shapes.

2. Rolling: The cast copper is then rolled into sheets, plates, or other forms.

Alternative Methods:

1. Hydrometallurgy: This method involves using a solution to extract copper from the ore, rather than smelting.

2. Bioleaching: This method uses microorganisms to extract copper from the ore.

 

·   What are the different dosage forms of Copper?

Oral Dosage Forms:

1. Tablets: Copper tablets are available in various strengths, often in combination with other nutrients.

2. Capsules: Copper capsules contain copper powder or pellets, often in a vegetarian or vegan-friendly format.

3. Softgels: Copper softgels are liquid-filled capsules that provide a convenient and easily absorbed form of copper.

4. Powders: Copper powders can be mixed with food or beverages, offering a flexible and customizable dosing option.

5. Liquid supplements: Copper liquid supplements are available in various flavors and can be taken directly or mixed with food and beverages.

 

Parenteral Dosage Forms:

1. Injectable solutions: Copper injectable solutions are used for intravenous or intramuscular administration, often in a clinical setting.

2. Implants: Copper implants are used for long-term copper supplementation, often in veterinary medicine.

 

Topical Dosage Forms:

1. Creams: Copper creams are applied directly to the skin, often for wound care or skin health.

2. Ointments: Copper ointments are similar to creams but have a thicker consistency, often used for skin conditions or wounds.

3. Transdermal patches: Copper transdermal patches are applied to the skin, releasing copper ions over an extended period.

 

Other Dosage Forms:

1. Intrauterine devices (IUDs): Copper IUDs are used for birth control and release copper ions locally.

2. Wound dressings: Copper-infused wound dressings are used to promote wound healing and tissue repair.

3. Food supplements: Copper is often added to food supplements, such as energy bars, beverages, or breakfast cereals.

 

 

 

·         How Copper‘s Dosage Forms are prepared?

Oral Dosage Forms:

1. Tablets:

    - Weighing and mixing of copper powder or granules with excipients (e.g., binders, fillers, lubricants).

    - Compression of the mixture into tablets using a tablet press.

    - Coating with a thin layer of material (e.g., wax, shellac) to improve appearance and durability.

2. Capsules:

    - Filling of copper powder or pellets into empty capsules.

    - Sealing of the capsules using a capsule sealing machine.

3. Softgels:

    - Mixing of copper oil or liquid with a gelatin-based mixture.

    - Encapsulation of the mixture into softgels using a softgel encapsulation machine.

4. Powders:

    - Grinding or milling of copper powder or granules into a fine powder.

    - Mixing with excipients (e.g., fillers, flavorings) as needed.

5. Liquid Supplements:

    - Dissolution of copper powder or granules in a liquid carrier (e.g., water, glycerin).

    - Mixing with excipients (e.g., flavorings, sweeteners) as needed.

 

Parenteral Dosage Forms:

1. Injectable Solutions:

    - Dissolution of copper powder or granules in a solvent (e.g., water, saline).

    - Filtration and sterilization of the solution using a filter and autoclave.

    - Filling and sealing of the solution into vials or ampoules.

2. Implants:

    - Mixing of copper powder or granules with a biocompatible polymer (e.g., silicone, polyurethane).

    - Extrusion or molding of the mixture into implantable devices (e.g., rods, pellets).

 

Topical Dosage Forms:

1. Creams:

    - Mixing of copper powder or granules with a cream base (e.g., petroleum jelly, lanolin).

    - Homogenization of the mixture using a homogenizer.

2. Ointments:

    - Mixing of copper powder or granules with an ointment base (e.g., petroleum jelly, beeswax).

    - Homogenization of the mixture using a homogenizer.

3. Transdermal Patches:

    - Mixing of copper powder or granules with a transdermal patch adhesive (e.g., acrylate, silicone).

    - Coating of the mixture onto a backing material (e.g., polyester, polyethylene).

 

Quality Control:

1. Raw material testing: Testing of raw materials (e.g., copper powder, excipients) for purity, potency, and quality.

2. In-process testing: Testing of intermediate products (e.g., tablet granules, liquid fills) for quality and purity.

3. Finished product testing: Testing of finished products (e.g., tablets, capsules, liquids) for quality, purity, and potency.

4. Stability testing: Testing of finished products for stability over time, including shelf life and storage conditions.

 

·         What are the appropriate Dosage forms of Copper ?

Oral Dosage Forms:

1. Tablets: Copper tablets are available in various strengths, often in combination with other nutrients.

2. Capsules: Copper capsules contain copper powder or pellets, often in a vegetarian or vegan-friendly format.

3. Softgels: Copper softgels are liquid-filled capsules that provide a convenient and easily absorbed form of copper.

4. Powders: Copper powders can be mixed with food or beverages, offering a flexible and customizable dosing option.

5. Liquid supplements: Copper liquid supplements are available in various flavors and can be taken directly or mixed with food and beverages.

 

Parenteral Dosage Forms:

1. Injectable solutions: Copper injectable solutions are used for intravenous or intramuscular administration, often in a clinical setting.

2. Implants: Copper implants are used for long-term copper supplementation, often in veterinary medicine.

 

Topical Dosage Forms:

1. Creams: Copper creams are applied directly to the skin, often for wound care or skin health.

2. Ointments: Copper ointments are similar to creams but have a thicker consistency, often used for skin conditions or wounds.

3. Transdermal patches: Copper transdermal patches are applied to the skin, releasing copper ions over an extended period.

 

Other Dosage Forms:

1. Intrauterine devices (IUDs): Copper IUDs are used for birth control and release copper ions locally.

2. Wound dressings: Copper-infused wound dressings are used to promote wound healing and tissue repair.

3. Food supplements: Copper is often added to food supplements, such as energy bars, beverages, or breakfast cereals.

 

Considerations:

1. Patient age and health status: The dosage form and strength of copper may vary depending on the patient's age, health status, and nutritional needs.

2. Route of administration: The route of administration (oral, parenteral, topical) may influence the choice of dosage form.

3. Dose and duration: The dose and duration of copper supplementation may vary depending on the intended use and patient response.

4. Combination with other nutrients: Copper may be combined with other nutrients, such as zinc, vitamin C, or iron, to enhance its effects or address specific nutritional needs.

 

 

 

·         When should Copper  be taken?

Best Time to Take Copper:

1. With meals: Taking copper with meals can enhance absorption and reduce gastrointestinal side effects.

2. In the morning: Taking copper in the morning can help boost energy levels and support immune function throughout the day.

3. Before bed: Taking copper before bed may help regulate sleep patterns and support antioxidant defenses during the night.

 

Considerations:

1. Food interactions: Avoid taking copper with foods high in fiber, calcium, or phosphorus, as these may interfere with absorption.

2. Medication interactions: Consult with a healthcare professional before taking copper with medications, especially blood thinners, as copper may interact with these medications.

3. Individual tolerance: Start with a low dose and gradually increase as needed and tolerated.

 

Special Circumstances:

1. Pregnancy and lactation: Consult with a healthcare professional before taking copper during pregnancy or lactation, as requirements may vary.

2. Gastrointestinal disorders: Individuals with gastrointestinal disorders, such as celiac disease or Crohn's disease, may need to take copper in a specific form or at a specific time to optimize absorption.

3. Kidney disease: Individuals with kidney disease may need to limit or avoid copper supplementation, as excessive intake can exacerbate kidney damage.

 

General Guidelines:

1. Follow the recommended dietary allowance (RDA): The RDA for copper is 900 mcg/day for adults.

2. Consult with a healthcare professional: Before taking copper supplements, especially if you have underlying medical conditions or take medications.

3. Monitor copper levels: Regularly monitor copper levels to avoid toxicity or deficiency.

 

·         What are the effects And Side effects of Copper ?

Beneficial Effects:

1. Connective tissue health: Copper is essential for the production of collagen, a protein that gives structure to connective tissue.

2. Immune system support: Copper plays a role in the production of white blood cells, which help fight infections.

3. Antioxidant properties: Copper has antioxidant properties, which help protect cells from damage caused by free radicals.

4. Brain function and development: Copper is involved in the synthesis of neurotransmitters and the development of the brain.

5. Wound healing: Copper is involved in the healing process of wounds, including the synthesis of collagen and the promotion of tissue repair.

 

Common Side Effects:

1. Nausea and vomiting: High doses of copper can cause nausea and vomiting.

2. Diarrhea: Copper supplements can cause diarrhea, especially when taken in high doses.

3. Abdominal pain: Copper can cause abdominal pain, especially when taken in high doses.

4. Headaches: Some people may experience headaches after taking copper supplements.

5. Fatigue: High doses of copper can cause fatigue and weakness.

 

Less Common Side Effects:

1. Skin rash: Some people may experience a skin rash after taking copper supplements.

2. Itching: Copper can cause itching, especially when taken in high doses.

3. Hair loss: High doses of copper can cause hair loss.

4. Muscle weakness: Copper can cause muscle weakness, especially when taken in high doses.

5. Joint pain: Some people may experience joint pain after taking copper supplements.

 

Serious Side Effects:

1. Copper toxicity: Taking high doses of copper can lead to copper toxicity, which can cause serious health problems, including liver damage and kidney damage.

2. Interactions with medications: Copper can interact with certain medications, including blood thinners, and decrease their effectiveness.

3. Kidney damage: High doses of copper can cause kidney damage and increase the risk of kidney disease.

 

Contraindications:

1. Pregnancy and lactation: High doses of copper should be avoided during pregnancy and lactation, as they can cause harm to the fetus or baby.

2. Kidney disease: Individuals with kidney disease should avoid taking high doses of copper, as they can exacerbate kidney damage.

3. Liver disease: Individuals with liver disease should avoid taking high doses of copper, as they can exacerbate liver damage.

 

Precautions:

1. Dosage: Copper supplements should be taken in recommended doses to avoid adverse effects.

2. Monitoring: Copper levels should be monitored regularly to avoid toxicity or deficiency.

3. Interactions: Copper can interact with certain medications, so it's essential to consult with a healthcare professional before taking copper supplements.

 

·         How is Copper Tested Qualitatively?

Chemical Tests:

1. Ammonia Test: Copper reacts with ammonia to form a deep blue-colored complex.

2. Hydrochloric Acid (HCl) Test: Copper reacts with HCl to form a green-colored solution.

3. Nitric Acid (HNO3) Test: Copper reacts with HNO3 to form a blue-colored solution.

4. Potassium Ferrocyanide Test: Copper reacts with potassium ferrocyanide to form a reddish-brown precipitate.

 

Spectroscopic Tests:

1. Atomic Absorption Spectroscopy (AAS): AAS is used to detect and quantify copper in a sample.

2. Inductively Coupled Plasma Mass Spectrometry (ICP-MS): ICP-MS is used to detect and quantify copper in a sample.

3. X-Ray Fluorescence (XRF): XRF is used to detect and quantify copper in a sample.

 

Spot Tests:

1. Copper Spot Test: A drop of copper solution is placed on a filter paper, and a few drops of ammonia are added. A deep blue color indicates the presence of copper.

2. Copper-2,2'-Biquinoline Spot Test: A drop of copper solution is placed on a filter paper, and a few drops of 2,2'-biquinoline are added. A yellow color indicates the presence of copper.

 

Other Tests:

1. Flame Test: Copper compounds produce a green or blue flame when heated in a flame test.

2. Electrochemical Test: Copper can be detected electrochemically using a copper electrode.

 

Quality Control:

1. Standardization: Standard copper solutions are used to standardize the tests.

2. Blank controls: Blank controls are used to ensure that the reagents and equipment are free from contamination.

3. Positive controls: Positive controls are used to verify the presence of copper in the sample.

 

·         Which tests are performed on Copper ?

Physical Tests:

1. Appearance: Visual inspection to check for color, texture, and physical form.

2. Odor: Olfactory inspection to check for any unusual or unpleasant odors.

3. Melting Point: Measurement of the temperature at which copper melts.

4. Density: Measurement of the mass per unit volume of copper.

 

Chemical Tests:

1. Assay: Determination of the percentage of copper present in the sample.

2. Impurities: Detection and quantification of impurities such as lead, arsenic, and mercury.

3. pH: Measurement of the acidity or alkalinity of copper solutions.

4. Solubility: Determination of the solubility of copper in various solvents.

 

Spectroscopic Tests:

1. Atomic Absorption Spectroscopy (AAS): Quantification of copper and impurities using AAS.

2. Inductively Coupled Plasma Mass Spectrometry (ICP-MS): Quantification of copper and impurities using ICP-MS.

3. X-Ray Fluorescence (XRF): Non-destructive analysis of copper and impurities using XRF.

 

Microbiological Tests:

1. Total Aerobic Microbial Count: Determination of the number of aerobic microorganisms present in the sample.

2. Total Yeast and Mold Count: Determination of the number of yeast and mold present in the sample.

3. Escherichia coli (E. coli): Detection and quantification of E. coli in the sample.

 

Toxicity Tests:

1. Acute Toxicity: Determination of the lethal dose of copper that causes death in a short period.

2. Chronic Toxicity: Determination of the effects of long-term exposure to copper.

3. Genotoxicity: Determination of the potential of copper to cause genetic damage.

 

Other Tests:

1. Heavy Metal Testing: Detection and quantification of heavy metals such as lead, mercury, and arsenic.

2. Particle Size Distribution: Determination of the size distribution of copper particles.

3. Moisture Content: Determination of the moisture content of copper.

 

Regulatory Requirements:

1. Compliance with FDA regulations: Copper must comply with FDA regulations, including 21 CFR Part 101 (Food Labeling) and 21 CFR Part 201 (Labeling Requirements for Prescription Drugs).

2. Compliance with USP guidelines: Copper must comply with USP guidelines for dietary supplements and pharmaceuticals.

3. Truthful and non-misleading labeling: Labeling must be truthful and non-misleading, avoiding exaggerated or unsubstantiated claims.

·         What are the challenges in Manufacturing of Copper  API?

 

 

Raw Material Challenges:

1. Ore quality: The quality of copper ore can vary significantly, affecting the final product's purity and quality.

2. Impurities: Copper ore often contains impurities like arsenic, lead, and mercury, which must be removed during processing.

3. Supply chain disruptions: Disruptions in the supply chain can impact the availability and quality of raw materials.

 

Process Challenges:

1. Extraction and purification: Copper extraction and purification processes can be complex and require specialized equipment.

2. Control of particle size: Controlling particle size is crucial to ensure uniformity and stability of the final product.

3. Temperature and humidity control: Copper is sensitive to temperature and humidity, requiring careful control during processing and storage.

 

Equipment Challenges:

1. Corrosion: Copper can corrode equipment, requiring specialized materials and coatings.

2. Equipment maintenance: Regular maintenance is necessary to prevent equipment failure and ensure consistent product quality.

3. Scalability: Equipment must be scalable to accommodate varying batch sizes and production demands.

 

Regulatory Challenges:

1. Compliance with cGMP: Manufacturers must comply with current Good Manufacturing Practice (cGMP) regulations to ensure product quality and safety.

2. Regulatory inspections: Manufacturers must be prepared for regulatory inspections and audits to ensure compliance.

3. Documentation and record-keeping: Accurate documentation and record-keeping are essential to demonstrate compliance and ensure product quality.

 

Quality Control Challenges:

1. Testing and validation: Manufacturers must develop and validate testing methods to ensure product quality and purity.

2. Stability testing: Stability testing is necessary to ensure the product remains stable and effective throughout its shelf life.

3. Contamination control: Manufacturers must implement controls to prevent contamination and ensure product quality.

 

Cost and Yield Challenges:

1. Raw material costs: Fluctuations in raw material costs can impact profitability.

2. Yield optimization: Manufacturers must optimize yields to minimize waste and reduce costs.

3. Energy and resource efficiency: Manufacturers must balance production costs with energy and resource efficiency.

 

Environmental Challenges:

1. Waste management: Manufacturers must manage waste generated during the production process, including hazardous materials.

2. Environmental regulations: Manufacturers must comply with environmental regulations, including those related to air and water pollution.

3. Sustainability: Manufacturers must consider the sustainability of their operations and minimize their environmental footprint.

 

 

 

·         What are the challenges in manufacturing of Copper ’s Dosage forms?

Oral Dosage Forms:

1. Bioavailability: Copper has poor bioavailability, making it challenging to ensure consistent absorption.

2. Stability: Copper is prone to oxidation, which can affect the stability of oral dosage forms.

3. Taste and odor: Copper has a distinct taste and odor, which can be unpleasant for patients.

4. Gastrointestinal side effects: Copper can cause gastrointestinal side effects, such as nausea and diarrhea.

Parenteral Dosage Forms:

1. Sterility: Parenteral dosage forms require strict sterility controls to prevent contamination.

2. Pyrogenicity: Copper can cause pyrogenic reactions, which can be challenging to control.

3. Stability: Copper is prone to degradation, which can affect the stability of parenteral dosage forms.

4. Particle size control: Controlling particle size is crucial to ensure consistent dosing and prevent blockages.

 

Topical Dosage Forms:

1. Skin penetration: Copper has limited skin penetration, making it challenging to ensure effective delivery.

2. Stability: Copper is prone to degradation, which can affect the stability of topical dosage forms.

3. Skin irritation: Copper can cause skin irritation, which can be challenging to control.

4. Cosmetic issues: Topical dosage forms require careful consideration of cosmetic issues, such as texture and appearance.

 

General Challenges:

1. Raw material quality: The quality of raw materials can significantly impact the final product's quality.

2. Equipment corrosion: Copper can corrode equipment, requiring specialized materials and coatings.

3. Regulatory compliance: Manufacturers must comply with regulatory requirements, including cGMP and USP guidelines.

4. Scalability: Manufacturers must ensure that their processes are scalable to accommodate varying batch sizes and production demands.

 

Quality Control Challenges:

1. Testing and validation: Manufacturers must develop and validate testing methods to ensure product quality and purity.

2. Stability testing: Stability testing is necessary to ensure the product remains stable and effective throughout its shelf life.

3. Contamination control: Manufacturers must implement controls to prevent contamination and ensure product quality.

 

Cost and Yield Challenges:

1. Raw material costs: Fluctuations in raw material costs can impact profitability.

2. Yield optimization: Manufacturers must optimize yields to minimize waste and reduce costs.

3. Energy and resource efficiency: Manufacturers must balance production costs with energy and resource efficiency.

 

·         What is the Packing for Copper ?

 

Primary Packaging:

1. Plastic bottles: Copper powder or granules are packed in plastic bottles with tight-fitting lids.

2. Glass bottles: Copper solutions or liquids are packed in glass bottles with tight-fitting lids.

3. Metal drums: Copper powder or granules are packed in metal drums with tight-fitting lids.

4. Fiber drums: Copper powder or granules are packed in fiber drums with tight-fitting lids.

 

Secondary Packaging:

1. Corrugated boxes: Primary packaging is placed in corrugated boxes for added protection.

2. Pallets: Corrugated boxes are stacked on pallets for easy transportation and storage.

3. Shrink wrapping: Pallets are wrapped in shrink wrap to prevent damage and contamination.

 

Specialized Packaging:

1. Moisture-resistant packaging: Copper is packed in moisture-resistant materials, such as foil or plastic bags, to prevent degradation.

2. Light-resistant packaging: Copper is packed in light-resistant materials, such as amber glass or plastic bottles, to prevent degradation.

3. Tamper-evident packaging: Copper is packed in tamper-evident materials, such as sealed bags or bottles, to prevent contamination.

 

Labeling and Documentation:

1. Labels: Packaging is labeled with relevant information, such as product name, batch number, and expiration date.

2. Safety Data Sheets (SDS): SDS are provided with packaging to ensure safe handling and use.

3. Certificates of Analysis (CoA): CoA are provided with packaging to ensure product quality and purity.

 

Storage and Transportation:

1. Cool, dry place: Copper is stored in a cool, dry place to prevent degradation.

2. Away from light: Copper is stored away from light to prevent degradation.

3. Secure transportation: Copper is transported in a secure manner to prevent damage and contamination.

 

 

·         What is shelf life Of Copper ? 

Forms of Copper:

1. Copper powder: 2-5 years when stored in a cool, dry place, away from light.

2. Copper granules: 2-5 years when stored in a cool, dry place, away from light.

3. Copper solutions: 1-3 years when stored in a cool, dry place, away from light.

4. Copper tablets or capsules: 2-5 years when stored in a cool, dry place, away from light.

 

Storage Conditions:

1. Temperature: Store copper in a cool, dry place with a temperature range of 15°C to 30°C (59°F to 86°F).

2. Humidity: Store copper in a dry place with a relative humidity of 50% to 70%.

3. Light: Store copper away from direct sunlight and UV light.

4. Air: Store copper in a well-ventilated area to prevent moisture accumulation.

 

Packaging:

1. Tight-fitting containers: Store copper in tight-fitting containers to prevent moisture and air from entering.

2. Moisture-resistant packaging: Use moisture-resistant packaging materials, such as foil or plastic bags, to prevent moisture from entering.

3. Light-resistant packaging: Use light-resistant packaging materials, such as amber glass or plastic bottles, to prevent light from entering.

 

Shelf Life Testing:

1. Stability testing: Perform stability testing on copper samples to determine the shelf life.

2. Accelerated stability testing: Perform accelerated stability testing on copper samples to determine the shelf life under extreme conditions.

 

Expiration Date:

1. Labeling: Label copper products with an expiration date or a "best by" date.

2. Expiration date calculation: Calculate the expiration date based on the shelf life testing data.

·         What should the label claim for Copper Include?

Mandatory Information:

1. Name and address of the manufacturer: The name and address of the manufacturer or distributor should be clearly stated on the label.

2. Product name: The product name should be clearly stated on the label.

3. Net quantity: The net quantity of copper in the container should be clearly stated on the label.

4. Directions for use: The directions for use, including the recommended dosage and frequency of administration, should be clearly stated on the label.

5. Warning statements: Warning statements, such as "Keep out of reach of children" and "If you are pregnant or breastfeeding, consult a healthcare professional before use," should be clearly stated on the label.

 

Nutrient Content Information:

1. Copper content: The amount of copper in each serving should be clearly stated on the label.

2. Daily Value (DV): The percentage of the Daily Value (DV) for copper should be clearly stated on the label.

3. Other nutrients: If the product contains other nutrients, such as zinc or vitamin C, the amount of each nutrient in each serving should be clearly stated on the label.

 

Claims and Statements:

1. Health claims: Any health claims, such as "Supports immune function" or "Helps maintain healthy connective tissue," should be clearly stated on the label and supported by scientific evidence.

2. Structure/function claims: Any structure/function claims, such as "Helps maintain healthy skin" or "Supports bone health," should be clearly stated on the label and supported by scientific evidence.

3. Other statements: Any other statements, such as "Vegetarian" or "Gluten-free," should be clearly stated on the label.

 

Certifications and Compliance:

1. USP verification: If the product is USP-verified, the USP verification mark should be displayed on the label.

2. NSF International certification: If the product is NSF International-certified, the NSF International certification mark should be displayed on the label.

3. Compliance with FDA regulations: The label should comply with FDA regulations, including 21 CFR Part 101 (Food Labeling) and 21 CFR Part 201 (Labeling Requirements for Prescription Drugs).

 

Other Information:

1. Lot number: The lot number should be clearly stated on the label.

2. Expiration date: The expiration date or "best by" date should be clearly stated on the label.

3. Storage instructions: Storage instructions, such as "Store in a cool, dry place," should be clearly stated on the label.

·         Where can Copper are procured?

Copper can be procured from various sources, depending on your location and requirements. Here are some options:

1.      FOR API

 MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com            

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com            

 GST No: 27DHUPM2366D1ZZ

 

2.      For Dosage Forms :

     - Online Marketplaces: You can find Copper   e products on online marketplaces like Amazon or e-       

        commerce websites specializing in pharmaceuticals or skincare products.

      - Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in             

        your area for Copper   e products.

       Remember to ensure the quality and authenticity of the Copper   e product, regardless of the          

        procurement source.