Phylloquinone 84-80-0 Manufacturer Exporter MEDIOCON INC
Phylloquinone Manufactured by MEDIOCON
INC
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·
Name: Phylloquinone
·
CAS
No: 84-80-0
·
Molecular Weight: 450.7g/mol
·
Molecular formula: C31H46O2
·
Synonyms: Vitamin K.
·
Chemical structure:
· Appearance:
Yellow
viscous liquid
· Solubility:
Insoluble
in water.
· Use :
Physiological Functions:
1. Blood clotting: Phylloquinone
Manufactured by MEDIOCON INC is necessary for the production of clotting
factors in the liver, which helps to stop bleeding when a blood vessel is
injured.
2. Bone health: Phylloquinone
Manufactured by MEDIOCON INC helps to regulate the activity of osteoclasts,
which are cells that break down bone tissue, and osteoblasts, which are cells
that build bone tissue.
3. Cardiovascular
health: Phylloquinone Manufactured by MEDIOCON INC helps to prevent the hardening of arteries,
which can reduce the risk of heart disease.
Medical Uses:
1. Treatment of bleeding
disorders: Phylloquinone Manufactured by MEDIOCON INC is
used to treat bleeding disorders, such as hemophilia, and to prevent bleeding
in people taking anticoagulant medications.
2. Prevention of vitamin
K deficiency: Phylloquinone Manufactured by MEDIOCON INC is
used to prevent vitamin K deficiency in newborns, especially those who are
breastfed.
3. Treatment of
osteoporosis: Phylloquinone Manufactured by MEDIOCON INC is
used to treat osteoporosis, especially in postmenopausal women.
Dietary Uses:
1. Fortification of
foods: Phylloquinone Manufactured by MEDIOCON INC is added to some foods, such as infant formula
and cereals, to prevent vitamin K deficiency.
2. Dietary supplements: Phylloquinone
Manufactured by MEDIOCON INC is available as a dietary supplement in
various forms, including capsules, tablets, and injections.
Research Uses:
1. Cancer research: Phylloquinone
Manufactured by MEDIOCON INC has been studied for its potential role in
preventing and treating certain types of cancer, such as prostate cancer.
2. Cardiovascular
research: Phylloquinone Manufactured by MEDIOCON INC has
been studied for its potential role in preventing and treating cardiovascular
disease.
3. Bone health research:
Phylloquinone Manufactured by MEDIOCON INC
has been studied for its
potential role in maintaining bone health and preventing osteoporosis.
· How is Phylloquinone Manufactured by MEDIOCON
INC Synthesized?
Chemical Synthesis:
1. Multi-step synthesis:
Phylloquinone Manufactured by MEDIOCON INC
can be synthesized through a
multi-step process involving the condensation of menadione with phytol or other
long-chain alcohols.
2. Catalytic
hydrogenation: The resulting product can be hydrogenated using a catalyst, such
as palladium or platinum, to produce Phylloquinone Manufactured by MEDIOCON
INC .
Microbial Fermentation:
1. Bacterial
fermentation: Phylloquinone Manufactured by MEDIOCON INC can
be produced through bacterial fermentation using microorganisms such as
Bacillus subtilis or Escherichia coli.
2. Fermentation
conditions: The fermentation process involves optimizing conditions such as
temperature, pH, and nutrient supply to promote the growth of the
microorganisms and the production of Phylloquinone Manufactured by MEDIOCON
INC .
Enzymatic Synthesis:
1. Enzyme-catalyzed
reaction: Phylloquinone Manufactured by MEDIOCON INC can
be synthesized through an enzyme-catalyzed reaction involving the condensation
of menadione with phytol or other long-chain alcohols.
2. Enzyme sources: The
enzymes used for this reaction can be sourced from microorganisms such as
bacteria or yeast.
Plant-Based Synthesis:
1. Plant cell culture: Phylloquinone
Manufactured by MEDIOCON INC can be produced through plant cell culture
using cells from plants such as spinach or alfalfa.
2. Plant-based
fermentation: The plant cells can be fermented to produce Phylloquinone
Manufactured by MEDIOCON INC .
Semi-Synthetic
Production:
1. Partial synthesis: Phylloquinone
Manufactured by MEDIOCON INC can
be produced through partial synthesis involving the modification of naturally
occurring compounds.
2. Enzymatic
modification: The resulting product can be modified using enzymes to produce Phylloquinone
Manufactured by MEDIOCON INC .
· What are the different dosage form of Phylloquinone
Manufactured by MEDIOCON INC ?
Oral Dosage Forms:
1. Tablets: Phylloquinone
Manufactured by MEDIOCON INC tablets are available in various strengths,
ranging from 5-100 mg.
2. Capsules: Phylloquinone
Manufactured by MEDIOCON INC capsules are available in various strengths,
ranging from 5-100 mg.
3. Softgels: Phylloquinone
Manufactured by MEDIOCON INC softgels are available in various strengths,
ranging from 5-100 mg.
4. Oral solutions: Phylloquinone
Manufactured by MEDIOCON INC oral solutions are available in various strengths,
ranging from 1-10 mg/ml.
Parenteral Dosage Forms:
1. Injectable solutions:
Phylloquinone Manufactured by MEDIOCON INC
injectable solutions are available
in various strengths, ranging from 1-10 mg/mL.
2. Injectable
suspensions: Phylloquinone Manufactured by MEDIOCON INC injectable suspensions are available in
various strengths, ranging from 1-10 mg/mL.
Topical Dosage Forms:
1. Creams: Phylloquinone
Manufactured by MEDIOCON INC creams are available in various strengths,
ranging from 0.1-5%.
2. Ointments: Phylloquinone
Manufactured by MEDIOCON INC ointments are available in various strengths,
ranging from 0.1-5%.
3. Gels: Phylloquinone
Manufactured by MEDIOCON INC gels are available in various strengths,
ranging from 0.1-5%.
Combination Dosage Forms:
1. Multivitamin tablets:
Phylloquinone Manufactured by MEDIOCON INC
is often combined with other
vitamins and minerals in multivitamin tablets.
2. Vitamin K combination
products: Phylloquinone Manufactured by MEDIOCON INC is
often combined with other forms of vitamin K, such as menaquinone, in
combination products.
Specialized Dosage Forms:
1. Pediatric drops: Phylloquinone
Manufactured by MEDIOCON INC pediatric drops are available in various
strengths, ranging from 1-10 mg/mL.
2. Neonatal injectables:
Phylloquinone Manufactured by MEDIOCON INC
neonatal injectables are
available in various strengths, ranging from 0.1-1 mg/mL.
·
How
Phylloquinone Manufactured by MEDIOCON INC
Dosage Forms are prepared?
Oral Dosage Forms:
1. Tablets: Phylloquinone Manufactured by MEDIOCON INC tablets are prepared by mixing the active
ingredient with excipients, such as binders, fillers, and lubricants. The
mixture is then compressed into tablets using a tablet press.
2. Capsules: Phylloquinone Manufactured by MEDIOCON
INC capsules are prepared by filling empty
capsules with a mixture of the active ingredient and excipients, such as
fillers and lubricants.
3. Softgels: Phylloquinone Manufactured by MEDIOCON
INC softgels are prepared by filling soft gelatin
capsules with a mixture of the active ingredient and excipients, such as oils
and waxes.
Parenteral Dosage Forms:
1. Injectable solutions: Phylloquinone Manufactured by
MEDIOCON INC injectable solutions are prepared by
dissolving the active ingredient in a solvent, such as water or saline, and
then filtering and sterilizing the solution.
2. Injectable suspensions: Phylloquinone Manufactured by
MEDIOCON INC injectable suspensions are prepared by mixing
the active ingredient with a solvent, such as water or saline, and then adding
a suspending agent, such as a polymer or a surfactant.
Topical Dosage Forms:
1. Creams: Phylloquinone Manufactured by MEDIOCON INC creams are prepared by mixing the active
ingredient with a base, such as a fatty acid or a wax, and then adding
emulsifiers and stabilizers.
2. Ointments: Phylloquinone Manufactured by MEDIOCON
INC ointments are prepared by mixing the active
ingredient with a base, such as a fatty acid or a wax, and then adding
stabilizers and preservatives.
3. Gels: Phylloquinone Manufactured by MEDIOCON INC gels are prepared by mixing the active
ingredient with a solvent, such as water or a glycol, and then adding a gelling
agent, such as a polymer or a surfactant.
Manufacturing Process:
1. Weighing and mixing: The active ingredient and excipients
are weighed and mixed together in a specific order.
2. Granulation: The mixture is then granulated to form a
uniform powder.
3. Compression or filling: The granules are then compressed
into tablets or filled into capsules or softgels.
4. Sterilization: Parenteral dosage forms are sterilized
using methods such as autoclaving or filtration.
5. Packaging: The final product is then packaged in a
suitable container, such as a bottle or a blister pack.
Quality Control:
1. Raw material testing: The quality of the raw materials
is tested before use.
2. In-process testing: The product is tested during
manufacturing to ensure it meets specifications.
3. Final product testing: The final product is tested to
ensure it meets specifications and is free from contaminants.
·
What
are the appropriate Dosage forms of Phylloquinone Manufactured by MEDIOCON
INC ?
Oral Dosage Forms:
1. Tablets: 5-25 mg per
tablet, suitable for adults and children.
2. Capsules: 5-25 mg per
capsule, suitable for adults and children.
3. Softgels: 5-25 mg per
softgel, suitable for adults and children.
4. Oral solutions: 1-5
mg/mL, suitable for infants, children, and adults who have difficulty
swallowing tablets or capsules.
Parenteral Dosage Forms:
1. Injectable solutions:
1-10 mg/mL, suitable for newborns, infants, and adults who require rapid
treatment.
2. Injectable
suspensions: 1-10 mg/mL, suitable for newborns, infants, and adults who require
rapid treatment.
Topical Dosage Forms:
1. Creams: 0.1-5% Phylloquinone
Manufactured by MEDIOCON INC ,
suitable for treating skin conditions such as ecchymoses and petechiae.
2. Ointments: 0.1-5% Phylloquinone
Manufactured by MEDIOCON INC ,
suitable for treating skin conditions such as ecchymoses and petechiae.
3. Gels: 0.1-5% Phylloquinone
Manufactured by MEDIOCON INC ,
suitable for treating skin conditions such as ecchymoses and petechiae.
Neonatal Dosage Forms:
1. Injectable solutions:
0.5-1 mg per dose, suitable for newborns.
2. Oral solutions: 0.5-1
mg per dose, suitable for newborns.
Pediatric Dosage Forms:
1. Oral solutions: 1-5
mg per dose, suitable for infants and children.
2. Tablets or capsules:
5-25 mg per dose, suitable for children and adolescents.
·
When
should Phylloquinone Manufactured by MEDIOCON INC be taken?
Timing of Phylloquinone Manufactured
by MEDIOCON INC Intake:
1. With meals: Phylloquinone
Manufactured by MEDIOCON INC is a fat-soluble vitamin, so it's best taken
with meals that contain fat to enhance absorption.
2. In the morning:
Taking Phylloquinone Manufactured by MEDIOCON INC in
the morning may help support bone health and blood clotting throughout the day.
3. Before surgery: Phylloquinone
Manufactured by MEDIOCON INC may be taken before surgery to help reduce the
risk of bleeding complications.
4. During pregnancy and
lactation: Phylloquinone Manufactured by MEDIOCON INC may
be taken during pregnancy and lactation to support fetal development and infant
health.
Special Considerations:
1. Newborns: Phylloquinone
Manufactured by MEDIOCON INC is typically administered to newborns within
the first hour of life to prevent vitamin K deficiency bleeding.
2. Infants and children:
Phylloquinone Manufactured by MEDIOCON INC
may be taken by infants and
children to support bone health and blood clotting.
3. Adults with medical
conditions: Adults with medical conditions such as liver disease, celiac
disease, or ulcerative colitis may require Phylloquinone Manufactured by
MEDIOCON INC supplements to support bone health and blood
clotting.
Interactions with Medications:
1. Anticoagulants: Phylloquinone
Manufactured by MEDIOCON INC may interact with anticoagulant medications,
such as warfarin, and reduce their effectiveness.
2. Blood thinners: Phylloquinone
Manufactured by MEDIOCON INC may interact with blood thinners, such as
aspirin, and increase the risk of bleeding.
Precautions:
1. Allergic reactions:
Individuals with a history of allergic reactions to Phylloquinone Manufactured
by MEDIOCON INC or other vitamins should exercise caution when
taking Phylloquinone Manufactured by MEDIOCON INC supplements.
2. Overdose: Taking high
doses of Phylloquinone Manufactured by MEDIOCON INC can
cause adverse effects, such as nausea, vomiting, and diarrhea.
·
What
are the effects And Side effects of Phylloquinone Manufactured by MEDIOCON
INC ?
Effects of Phylloquinone Manufactured
by MEDIOCON INC :
1. Blood clotting: Phylloquinone
Manufactured by MEDIOCON INC helps to promote blood clotting, which can be
beneficial for individuals with bleeding disorders.
2. Bone health: Phylloquinone
Manufactured by MEDIOCON INC helps to regulate the activity of osteoclasts,
which can help to maintain bone density and reduce the risk of fractures.
3. Cardiovascular
health: Phylloquinone Manufactured by MEDIOCON INC may
help to reduce the risk of cardiovascular disease by preventing the hardening
of arteries.
Common Side Effects of Phylloquinone
Manufactured by MEDIOCON INC :
1. Nausea and vomiting: High doses of Phylloquinone Manufactured by
MEDIOCON INC can cause nausea and vomiting.
2. Diarrhea: Phylloquinone
Manufactured by MEDIOCON INC can cause diarrhea, especially when taken in
high doses.
3. Abdominal cramps:
Some individuals may experience abdominal cramps or discomfort after taking Phylloquinone
Manufactured by MEDIOCON INC .
4. Allergic reactions:
Rarely, individuals may experience allergic reactions to Phylloquinone
Manufactured by MEDIOCON INC , such
as hives, itching, or difficulty breathing.
Rare but Serious Side Effects of Phylloquinone
Manufactured by MEDIOCON INC :
1. Hemolysis: High doses
of Phylloquinone Manufactured by MEDIOCON INC can
cause hemolysis, a condition in which red blood cells are destroyed.
2. Kernicterus: Phylloquinone
Manufactured by MEDIOCON INC can cause kernicterus, a condition in which
bilirubin builds up in the brain, in newborns.
3. Anaphylaxis: Rarely,
individuals may experience anaphylaxis, a severe allergic reaction that can be
life-threatening.
Interactions with Medications:
1. Anticoagulants: Phylloquinone
Manufactured by MEDIOCON INC can interact with anticoagulant medications,
such as warfarin, and reduce their effectiveness.
2. Blood thinners: Phylloquinone
Manufactured by MEDIOCON INC can interact with blood thinners, such as
aspirin, and increase the risk of bleeding.
Precautions:
1. Pregnancy and
lactation: Phylloquinone Manufactured by MEDIOCON INC is
generally considered safe during pregnancy and lactation, but high doses should
be avoided.
2. Newborns: Phylloquinone
Manufactured by MEDIOCON INC should be used with caution in newborns, as
high doses can cause kernicterus.
3. Liver disease:
Individuals with liver disease should use Phylloquinone Manufactured by
MEDIOCON INC with caution, as it can exacerbate liver
damage.
·
How
is Phylloquinone Manufactured by MEDIOCON INC Tested
Qualitatively?
Chemical Tests:
1. Colorimetric test: Phylloquinone
Manufactured by MEDIOCON INC can be detected using a colorimetric test,
which involves reacting the sample with a chemical reagent to produce a colored
compound.
2. Fluorescence test: Phylloquinone
Manufactured by MEDIOCON INC can be detected using a fluorescence test,
which involves exciting the sample with ultraviolet light and measuring the
resulting fluorescence.
3. Thin-layer
chromatography (TLC): Phylloquinone Manufactured by MEDIOCON INC can
be separated and identified using TLC, which involves separating the sample
components based on their affinity for a stationary phase.
Spectroscopic Tests:
1. Ultraviolet-visible
(UV-Vis) spectroscopy: Phylloquinone Manufactured by MEDIOCON INC can
be identified using UV-Vis spectroscopy, which involves measuring the
absorption of light by the sample in the ultraviolet and visible regions.
2. Infrared (IR)
spectroscopy: Phylloquinone Manufactured by MEDIOCON INC can
be identified using IR spectroscopy, which involves measuring the absorption of
light by the sample in the infrared region.
3. Nuclear magnetic
resonance (NMR) spectroscopy: Phylloquinone Manufactured by MEDIOCON INC can
be identified using NMR spectroscopy, which involves measuring the interaction
between the sample and a magnetic field.
Chromatographic Tests:
1. High-performance
liquid chromatography (HPLC): Phylloquinone Manufactured by MEDIOCON INC can
be separated and identified using HPLC, which involves separating the sample
components based on their affinity for a stationary phase.
2. Gas chromatography
(GC): Phylloquinone Manufactured by MEDIOCON INC can
be separated and identified using GC, which involves separating the sample
components based on their boiling points and affinity for a stationary phase.
Biological Tests:
1. Prothrombin time (PT)
test: Phylloquinone Manufactured by MEDIOCON INC can
be detected using a PT test, which involves measuring the time it takes for
blood to clot in the presence of Phylloquinone Manufactured by MEDIOCON
INC .
2. Vitamin K-dependent
clotting factors test: Phylloquinone Manufactured by MEDIOCON INC can
be detected using a test that measures the activity of vitamin K-dependent
clotting factors in the blood.
·
Which tests are performed on Phylloquinone Manufactured by
MEDIOCON INC ?
Physical Tests:
1. Appearance: Phylloquinone
Manufactured by MEDIOCON INC is tested for its appearance, including its
color, clarity, and texture.
2. Odor: Phylloquinone
Manufactured by MEDIOCON INC is tested for its odor to ensure it is free
from any unpleasant or unusual smells.
3. Melting point: Phylloquinone
Manufactured by MEDIOCON INC is tested for its melting point to ensure it
meets the specified range.
Chemical Tests:
1. Assay: Phylloquinone
Manufactured by MEDIOCON INC is tested for its potency using an assay
method, such as high-performance liquid chromatography (HPLC) or gas
chromatography (GC).
2. Impurities: Phylloquinone
Manufactured by MEDIOCON INC is tested for impurities, such as related
compounds, heavy metals, and residual solvents.
3. pH: Phylloquinone
Manufactured by MEDIOCON INC is tested for its pH to ensure it meets the
specified range.
Spectroscopic Tests:
1. Infrared (IR)
spectroscopy: Phylloquinone Manufactured by MEDIOCON INC is
tested using IR spectroscopy to confirm its identity and structure.
2. Ultraviolet-visible
(UV-Vis) spectroscopy: Phylloquinone Manufactured by MEDIOCON INC is
tested using UV-Vis spectroscopy to confirm its identity and purity.
3. Nuclear magnetic
resonance (NMR) spectroscopy: Phylloquinone Manufactured by MEDIOCON INC is
tested using NMR spectroscopy to confirm its identity and structure.
Chromatographic Tests:
1. High-performance
liquid chromatography (HPLC): Phylloquinone Manufactured by MEDIOCON INC is
tested using HPLC to confirm its identity, purity, and potency.
2. Gas chromatography
(GC): Phylloquinone Manufactured by MEDIOCON INC is
tested using GC to confirm its identity, purity, and potency.
3. Thin-layer
chromatography (TLC): Phylloquinone Manufactured by MEDIOCON INC is
tested using TLC to confirm its identity and purity.
Biological Tests:
1. Prothrombin time (PT)
test: Phylloquinone Manufactured by MEDIOCON INC is
tested using a PT test to confirm its biological activity.
2. Vitamin K-dependent
clotting factors test: Phylloquinone Manufactured by MEDIOCON INC is
tested using a test that measures the activity of vitamin K-dependent clotting
factors in the blood.
Stability Tests:
1. Accelerated stability
testing: Phylloquinone Manufactured by MEDIOCON INC is
tested for its stability under accelerated conditions, such as high temperature
and humidity.
2. Long-term stability
testing: Phylloquinone Manufactured by MEDIOCON INC is
tested for its stability over a longer period, typically 12-24 months.
·
What are the challenges in Manufacturing Of Phylloquinone
Manufactured by MEDIOCON INC API?
Raw Material Challenges:
1. Availability and
quality of raw materials: Phylloquinone Manufactured by MEDIOCON INC API
requires high-quality raw materials, such as phytol and menadione, which can be
difficult to source.
2. Purity of raw
materials: The purity of raw materials can affect the quality of the final API
product.
3. Stability of raw
materials: Raw materials can degrade over time, affecting the quality of the
final API product.
Synthesis Challenges:
1. Complexity of
synthesis: Phylloquinone Manufactured by MEDIOCON INC API
synthesis involves multiple steps, including condensation, hydrogenation, and
crystallization, which can be challenging to optimize.
2. Yield and efficiency:
The synthesis process can result in low yields and inefficient use of raw
materials.
3. Purification
challenges: The purification of Phylloquinone Manufactured by MEDIOCON INC API
can be challenging due to the presence of impurities and by-products.
Process Development Challenges:
1. Scalability: The
synthesis process may not be scalable, resulting in difficulties in producing
large quantities of API.
2. Reproducibility: The
synthesis process may not be reproducible, resulting in variations in API
quality.
3. Process optimization:
The synthesis process may require optimization to improve yield, efficiency,
and purity.
Quality Control Challenges:
1. Impurity control: Phylloquinone
Manufactured by MEDIOCON INC API can contain impurities, such as related
compounds, heavy metals, and residual solvents, which must be controlled.
2. Purity testing: The
purity of Phylloquinone Manufactured by MEDIOCON INC API
must be tested using various analytical techniques, such as HPLC and GC.
3. Stability testing:
The stability of Phylloquinone Manufactured by MEDIOCON INC API
must be tested to ensure its quality and shelf life.
Regulatory Challenges:
1. Compliance with
regulations: Phylloquinone Manufactured by MEDIOCON INC API
manufacturers must comply with various regulations, such as cGMP and ICH
guidelines.
2. Documentation and
record-keeping: Manufacturers must maintain accurate documentation and records
of the synthesis, purification, and testing of Phylloquinone Manufactured by
MEDIOCON INC API.
3. Audits and
inspections: Manufacturers must be prepared for audits and inspections by
regulatory agencies to ensure compliance with regulations.
·
What
are the challenges in manufacturing of Phylloquinone Manufactured by MEDIOCON
INC ’s Dosage forms?
Tablet Dosage Forms:
1. Compression
challenges: Phylloquinone Manufactured by MEDIOCON INC tablets can be difficult to compress due to
the poor flow properties of the powder.
2. Disintegration and
dissolution: Phylloquinone Manufactured by MEDIOCON INC tablets may not disintegrate or dissolve
properly, affecting the bioavailability of the active ingredient.
3. Stability: Phylloquinone
Manufactured by MEDIOCON INC tablets may be prone to degradation, affecting
their potency and shelf life.
Capsule Dosage Forms:
1. Fill weight
variability: Phylloquinone Manufactured by MEDIOCON INC capsules may have variable fill weights,
affecting the accuracy of the dosage.
2. Moisture content: Phylloquinone
Manufactured by MEDIOCON INC capsules may absorb moisture, affecting the
stability and potency of the active ingredient.
3. Dissolution: Phylloquinone
Manufactured by MEDIOCON INC capsules may not dissolve properly, affecting
the bioavailability of the active ingredient.
Liquid Dosage Forms:
1. Solubility
challenges: Phylloquinone Manufactured by MEDIOCON INC may
not be soluble in certain solvents, affecting the stability and potency of the
active ingredient.
2. Preservation: Phylloquinone
Manufactured by MEDIOCON INC liquid dosage forms may require preservatives
to prevent microbial growth, which can affect the stability and safety of the
product.
3. Stability: Phylloquinone
Manufactured by MEDIOCON INC liquid dosage forms may be prone to
degradation, affecting their potency and shelf life.
Topical Dosage Forms:
1. Skin penetration: Phylloquinone
Manufactured by MEDIOCON INC topical dosage forms may not penetrate the
skin effectively, affecting their bioavailability and efficacy.
2. Stability: Phylloquinone
Manufactured by MEDIOCON INC topical dosage forms may be prone to
degradation, affecting their potency and shelf life.
3. Skin irritation: Phylloquinone
Manufactured by MEDIOCON INC topical dosage forms may cause skin irritation
or allergic reactions, affecting their safety and tolerability.
Parenteral Dosage Forms:
1. Sterility: Phylloquinone
Manufactured by MEDIOCON INC Parenteral dosage forms must be sterile to
prevent microbial contamination and infection.
2. Pyrogenicity: Phylloquinone
Manufactured by MEDIOCON INC Parenteral dosage forms must be free from
pyrogens, which can cause fever and other systemic reactions.
3. Stability: Phylloquinone
Manufactured by MEDIOCON INC Parenteral dosage forms may be prone to
degradation, affecting their potency and shelf life.
General Challenges:
1. Raw material quality:
The quality of raw materials, including Phylloquinone Manufactured by MEDIOCON
INC , excipients, and packaging materials,
can affect the quality and stability of the final product.
2. Manufacturing
process: The manufacturing process, including equipment, personnel, and
environmental factors, can affect the quality and stability of the final
product.
3. Regulatory compliance:
Manufacturers must comply with various regulations, including cGMP and ICH
guidelines, to ensure the quality and safety of the final product.
·
What
are the storage conditions of Phylloquinone Manufactured by MEDIOCON INC ?
General Storage Conditions:
1. Temperature: Store Phylloquinone
Manufactured by MEDIOCON INC in a cool, dry place at a temperature between
15°C to 30°C (59°F to 86°F).
2. Humidity: Store Phylloquinone
Manufactured by MEDIOCON INC in a dry place with a relative humidity of 60%
or less.
3. Light: Protect Phylloquinone
Manufactured by MEDIOCON INC from direct sunlight and UV light.
Specific Storage Conditions:
1. Phylloquinone
Manufactured by MEDIOCON INC powder: Store Phylloquinone Manufactured by
MEDIOCON INC powder in a tightly sealed container,
protected from light and moisture.
2. Phylloquinone
Manufactured by MEDIOCON INC tablets or capsules: Store Phylloquinone
Manufactured by MEDIOCON INC tablets or capsules in a tightly sealed container,
protected from light and moisture.
3. Phylloquinone
Manufactured by MEDIOCON INC injectable solutions: Store Phylloquinone
Manufactured by MEDIOCON INC injectable solutions in a refrigerator at a
temperature between 2°C to 8°C (36°F to 46°F).
4. Phylloquinone
Manufactured by MEDIOCON INC topical preparations: Store Phylloquinone
Manufactured by MEDIOCON INC topical preparations in a tightly sealed Handling Precautions:
container, protected
from light and moisture.
1. Handle with care:
Handle Phylloquinone Manufactured by MEDIOCON INC with care to avoid damage or contamination.
2. Avoid exposure to
air: Avoid exposing Phylloquinone Manufactured by MEDIOCON INC to
air, as it can oxidize and degrade.
3. Avoid exposure to
moisture: Avoid exposing Phylloquinone Manufactured by MEDIOCON INC to
moisture, as it can degrade or become contaminated.
Shelf Life:
1. Phylloquinone
Manufactured by MEDIOCON INC powder: The shelf life of Phylloquinone
Manufactured by MEDIOCON INC powder is typically 2-3 years from the date of
manufacture.
2. Phylloquinone
Manufactured by MEDIOCON INC tablets or capsules: The shelf life of Phylloquinone
Manufactured by MEDIOCON INC tablets or capsules is typically 2-3 years
from the date of manufacture.
3. Phylloquinone
Manufactured by MEDIOCON INC injectable solutions: The shelf life of Phylloquinone
Manufactured by MEDIOCON INC injectable solutions is typically 1-2 years
from the date of manufacture.
4. Phylloquinone Manufactured
by MEDIOCON INC topical preparations: The shelf life of Phylloquinone
Manufactured by MEDIOCON INC topical preparations is typically 1-2 years
from the date of manufacture.
·
What
is the Packing for Phylloquinone Manufactured by MEDIOCON INC ?
Primary Packaging:
1. Glass bottles: Phylloquinone
Manufactured by MEDIOCON INC powder or capsules can be packaged in glass
bottles with tight-fitting lids to protect against moisture and light.
2. Plastic bottles: Phylloquinone
Manufactured by MEDIOCON INC powder or capsules can be packaged in plastic
bottles with tight-fitting lids to protect against moisture and light.
3. Aluminum or tin
tubes: Phylloquinone Manufactured by MEDIOCON INC ointments
or creams can be packaged in aluminum or tin tubes with tight-fitting caps to
protect against moisture and light.
4. Ampoules or vials: Phylloquinone
Manufactured by MEDIOCON INC injectable solutions can be packaged in
ampoules or vials with tight-fitting stoppers to protect against moisture and
contamination.
Secondary Packaging:
1. Cartons: Phylloquinone
Manufactured by MEDIOCON INC primary packaging can be placed in cartons to
provide additional protection against moisture, light, and physical damage.
2. Pouches or bags: Phylloquinone
Manufactured by MEDIOCON INC primary packaging can be placed in pouches or
bags to provide additional protection against moisture and contamination.
3. Trays or blister
packs: Phylloquinone Manufactured by MEDIOCON INC tablets or capsules can be packaged in trays
or blister packs to provide additional protection against moisture and physical
damage.
Tertiary Packaging:
1. Boxes or cases: Phylloquinone
Manufactured by MEDIOCON INC secondary packaging can be placed in boxes or
cases to provide additional protection against physical damage and moisture
during transportation and storage.
2. Pallets: Phylloquinone
Manufactured by MEDIOCON INC tertiary packaging can be placed on pallets to
facilitate transportation and storage.
Specialized Packaging:
1. Light-protective
packaging: Phylloquinone Manufactured by MEDIOCON INC can
be packaged in light-protective packaging, such as amber glass bottles or
opaque plastic bottles, to protect against light degradation.
2. Moisture-protective
packaging: Phylloquinone Manufactured by MEDIOCON INC can
be packaged in moisture-protective packaging, such as desiccant-containing
sachets or silica gel packets, to protect against moisture degradation.
3.
Temperature-controlled packaging: Phylloquinone Manufactured by MEDIOCON
INC can be packaged in temperature-controlled
packaging, such as insulated boxes or refrigerated containers, to protect
against temperature fluctuations during transportation and storage.
·
What
is shelf life Of Phylloquinone Manufactured by MEDIOCON INC ?
Shelf Life of Phylloquinone
Manufactured by MEDIOCON INC Dosage Forms:
1. Phylloquinone
Manufactured by MEDIOCON INC powder: 2-3 years from the date of manufacture
when stored in a cool, dry place, protected from light and moisture.
2. Phylloquinone
Manufactured by MEDIOCON INC tablets or capsules: 2-3 years from the date
of manufacture when stored in a cool, dry place, protected from light and
moisture.
3. Phylloquinone
Manufactured by MEDIOCON INC injectable solutions: 1-2 years from the date
of manufacture when stored in a refrigerator at a temperature between 2°C to
8°C (36°F to 46°F).
4. Phylloquinone
Manufactured by MEDIOCON INC topical preparations: 1-2 years from the date
of manufacture when stored in a cool, dry place, protected from light and
moisture.
Factors Affecting Shelf Life:
1. Temperature: High
temperatures can cause Phylloquinone Manufactured by MEDIOCON INC to
degrade, reducing its potency and shelf life.
2. Humidity: High
humidity can cause Phylloquinone Manufactured by MEDIOCON INC to
degrade, reducing its potency and shelf life.
3. Light: Direct
sunlight or UV light can cause Phylloquinone Manufactured by MEDIOCON INC to
degrade, reducing its potency and shelf life.
4. Moisture: Exposure to
moisture can cause Phylloquinone Manufactured by MEDIOCON INC to
degrade, reducing its potency and shelf life.
5. Packaging: The type
and quality of packaging can affect the shelf life of Phylloquinone
Manufactured by MEDIOCON INC .
Storage Recommendations:
1. Store in a cool, dry
place: Store Phylloquinone Manufactured by MEDIOCON INC in
a cool, dry place, protected from light and moisture.
2. Refrigerate
injectable solutions: Store Phylloquinone Manufactured by MEDIOCON INC injectable solutions in a refrigerator at a
temperature between 2°C to 8°C (36°F to 46°F).
3. Protect from light:
Protect Phylloquinone Manufactured by MEDIOCON INC from direct sunlight or UV light.
4. Check expiration
date: Check the expiration date or shelf life of Phylloquinone Manufactured by
MEDIOCON INC before using it.
·
What
should the label claim for Phylloquinone Manufactured by MEDIOCON INC Include?
Mandatory Label Claims:
1. Name of the product:
The name of the product, including the brand name and generic name (Phylloquinone
Manufactured by MEDIOCON INC or vitamin K1).
2. Strength or potency:
The strength or potency of Phylloquinone Manufactured by MEDIOCON INC in
the product, expressed in milligrams (mg) or micrograms (mcg) per serving.
3. Dosage form: The
dosage form of the product, such as tablets, capsules, injectable solutions, or
topical preparations.
4. Net quantity: The net
quantity of the product, expressed in terms of weight or volume.
5. Expiration date or
shelf life: The expiration date or shelf life of the product.
Recommended Label Claims:
1. Indications: The
indications for use of Phylloquinone Manufactured by MEDIOCON INC , such as prevention or treatment of
vitamin K deficiency, bleeding disorders, or osteoporosis.
2. Directions for use:
The directions for use of Phylloquinone Manufactured by MEDIOCON INC , including dosage instructions,
administration route, and frequency of use.
3. Warnings and
precautions: Warnings and precautions related to the use of Phylloquinone
Manufactured by MEDIOCON INC , such
as potential interactions with other medications, allergic reactions, or
adverse effects.
4. Contraindications:
Contraindications for the use of Phylloquinone Manufactured by MEDIOCON
INC , such as hypersensitivity to Phylloquinone
Manufactured by MEDIOCON INC or other ingredients in the product.
5. Side effects:
Potential side effects of Phylloquinone Manufactured by MEDIOCON INC , such as nausea, vomiting, diarrhea, or
abdominal pain.
Additional Label Claims:
1. Storage instructions:
Instructions for storing the product, such as keeping it in a cool, dry place
or refrigerating it.
2. Packaging
information: Information about the packaging, such as the type of container,
closure, and labeling.
3. Manufacturer
information: Information about the manufacturer, including their name, address,
and contact details.
4. Regulatory
compliance: Statements indicating compliance with relevant regulations, such as
cGMP or ICH guidelines.
·
Where
can Phylloquinone Manufactured by MEDIOCON INC are
procured?
Phylloquinone
Manufactured by MEDIOCON INC can be procured from various sources,
depending on your location and requirements. Here are some options:
1.
FOR API
MEDIOCON INC
Add: B-2, ARCH SARTHAK BUILDING,
N-7 CIDCO
CHATRAPATI SAMBHAJI NAGAR-431003,
MAHARASHTRA, INDIA
Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939
Sales Department: Email: sales@mediocon.com
Purchase Department: Email: purchase@mediocon.com
Marketing Department:
Email: mktg@mediocon.com
HR Department: Email: hr@mediocon.com
Accounts
Department: Email: accounts@mediocon.com
Email id:info@mediocon.com
GST No: 27DHUPM2366D1ZZ
2.
For Dosage Forms :
- Online
Marketplaces: You can find Phylloquinone Manufactured by MEDIOCON INC products on online marketplaces like
Amazon or e-
commerce websites specializing
in pharmaceuticals or skincare products.
- Local Pharmacies or Skincare Stores:
You can also check with local pharmacies or skincare stores in
your area for Phylloquinone
Manufactured by MEDIOCON INC products.
Remember to ensure the
quality and authenticity of the Phylloquinone Manufactured by MEDIOCON INC product, regardless of the procurement
source.
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