Quercetin Dihydrate 6151-25-3 Manufacturer Exporter MEDIOCON INC

 

Quercetin Dihydrate Manufactured by MEDIOCON INC 

 

·   Name: Quercetin Dihydrate

 

·   CAS No: 6151-25-3

·   Molecular Weight: 338.27g/mol

 

·   Molecular formula: C₁₅H₁₀O₇.2H₂O

 

·         Synonyms:  Flavone, 3,3',4',5,7-pentahydroxy-,dihydrate

·   Appearance: Yellow powder with a green or brown cast

 

·   Solubility: Soluble in 100% ethanol or 1M sodium hydroxide; almost insoluble in water.

 

·     Use :

Antioxidant Properties:

1. Free radical scavenger: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to scavenge free radicals, which can help protect cells from oxidative damage.

2. Antioxidant activity: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to have antioxidant activity, which can help protect against chronic diseases such as cancer, cardiovascular disease, and neurodegenerative diseases.

 

Anti-Inflammatory Properties:

1. Inflammation reduction: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to reduce inflammation, which can help alleviate symptoms of conditions such as arthritis, allergies, and asthma.

2. Immune system modulation: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to modulate the immune system, which can help prevent infections and autoimmune diseases.

 

Cardiovascular Health:

1. Blood pressure reduction: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to help reduce blood pressure, which can help prevent cardiovascular disease.

2. Cardiovascular protection: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to have cardiovascular protective effects, including reducing inflammation and improving blood vessel function.

 

Anti-Cancer Properties:

1. Cancer cell inhibition: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to inhibit the growth of cancer cells, including breast, prostate, and colon cancer cells.

2. Apoptosis induction: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to induce apoptosis (cell death) in cancer cells, which can help prevent cancer progression.

 

Neuroprotective Properties:

1. Neuroinflammation reduction: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to reduce neuroinflammation, which can help prevent neurodegenerative diseases such as Alzheimer's and Parkinson's.

2. Neuroprotection: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to have neuroprotective effects, including reducing oxidative stress and improving cognitive function.

 

Other Potential Benefits:

1. Anti-allergic properties: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to have anti-allergic properties, which can help alleviate symptoms of allergies.

2. Anti-viral properties: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to have anti-viral properties, which can help prevent viral infections.

3. Gastrointestinal health: Quercetin Dihydrate Manufactured by MEDIOCON INC  has been shown to have prebiotic properties, which can help promote gastrointestinal health.

 

Dosage and Administration:

1. Typical dosage: The typical dosage of Quercetin Dihydrate Manufactured by MEDIOCON INC  is 500-1,000 mg per day.

2. Administration: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be administered orally, typically in capsule or tablet form.

 

Precautions and Contraindications:

1. Pregnancy and breastfeeding: Quercetin Dihydrate Manufactured by MEDIOCON INC  should be used with caution during pregnancy and breastfeeding, as its effects on the fetus or baby are not well understood.

2. Interactions with medications: Quercetin Dihydrate Manufactured by MEDIOCON INC  may interact with certain medications, including blood thinners, diabetes medications, and certain antibiotics.

3. Allergic reactions: Quercetin Dihydrate Manufactured by MEDIOCON INC  may cause allergic reactions in some individuals, including hives, itching, and difficulty breathing.

 

·      How is Quercetin Dihydrate Manufactured by MEDIOCON INC   Synthesized?

 

Method 1: Extraction from Natural Sources

1. Plant material selection: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be extracted from various plant sources, such as leaves, stems, and flowers.

2. Extraction methods: The plant material is extracted using solvents such as ethanol, methanol, or acetone.

3. Purification: The extracted quercetin is purified using techniques such as recrystallization, chromatography, or distillation.

 

Method 2: Chemical Synthesis

1. Starting materials: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be synthesized from starting materials such as 3,4-dihydroxybenzoic acid, 2-hydroxybenzoic acid, and 2,4-dihydroxyacetophenone.

2. Condensation reaction: The starting materials are condensed in the presence of a catalyst, such as sulfuric acid or hydrochloric acid, to form quercetin.

3. Hydrolysis: The quercetin is then hydrolyzed to form quercetin dihydrate.

 

Method 3: Enzymatic Synthesis

1. Enzyme selection: Enzymes such as flavonoid synthase or chalcone synthase can be used to synthesize quercetin dihydrate.

2. Substrate preparation: The substrates, such as 4-coumaroyl-CoA and malonyl-CoA, are prepared and added to the enzyme reaction mixture.

3. Enzymatic reaction: The enzyme catalyzes the reaction to form quercetin dihydrate.

 

Method 4: Microbial Synthesis

1. Microorganism selection: Microorganisms such as bacteria or yeast can be used to synthesize quercetin dihydrate.

2. Fermentation: The microorganism is fermented in a suitable medium to produce quercetin dihydrate.

3. Purification: The Quercetin Dihydrate Manufactured by MEDIOCON INC  is purified from the fermentation broth using techniques such as chromatography or distillation.

 

Quality Control:

1. Purity analysis: The purity of the synthesized Quercetin Dihydrate Manufactured by MEDIOCON INC  is analyzed using techniques such as HPLC or GC.

2. Structural analysis: The structure of the synthesized Quercetin Dihydrate Manufactured by MEDIOCON INC  is confirmed using techniques such as NMR or MS.

3. Stability testing: The stability of the synthesized Quercetin Dihydrate Manufactured by MEDIOCON INC  is tested under various conditions, such as temperature, humidity, and light.

 

·   What are the different dosage forms of Quercetin Dihydrate Manufactured by MEDIOCON INC   ?

 

Oral Dosage Forms:

1. Tablets: Quercetin Dihydrate Manufactured by MEDIOCON INC  tablets are available in various strengths, ranging from 500 mg to 1,000 mg per tablet.

2. Capsules: Quercetin Dihydrate Manufactured by MEDIOCON INC  capsules are available in various strengths, ranging from 500 mg to 1,000 mg per capsule.

3. Softgels: Quercetin Dihydrate Manufactured by MEDIOCON INC  softgels are available in various strengths, ranging from 500 mg to 1,000 mg per softgel.

4. Powders: Quercetin Dihydrate Manufactured by MEDIOCON INC  powders are available in various strengths, ranging from 500 mg to 1,000 mg per scoop.

5. Liquid extracts: Quercetin Dihydrate Manufactured by MEDIOCON INC  liquid extracts are available in various strengths, ranging from 500 mg to 1,000 mg per mL.

 

Topical Dosage Forms:

1. Creams: Quercetin Dihydrate Manufactured by MEDIOCON INC  creams are available for topical application, typically in concentrations ranging from 1% to 5%.

2. Ointments: Quercetin Dihydrate Manufactured by MEDIOCON INC  ointments are available for topical application, typically in concentrations ranging from 1% to 5%.

3. Gels: Quercetin Dihydrate Manufactured by MEDIOCON INC  gels are available for topical application, typically in concentrations ranging from 1% to 5%.

4. Sprays: Quercetin Dihydrate Manufactured by MEDIOCON INC  sprays are available for topical application, typically in concentrations ranging from 1% to 5%.

 

Parenteral Dosage Forms:

1. Injectable solutions: Quercetin Dihydrate Manufactured by MEDIOCON INC  injectable solutions are available for intravenous or intramuscular administration.

2. Implants: Quercetin Dihydrate Manufactured by MEDIOCON INC  implants are available for subcutaneous or intramuscular administration.

 

Veterinary Dosage Forms:

1. Oral powders: Quercetin Dihydrate Manufactured by MEDIOCON INC  oral powders are available for veterinary use, typically in strengths ranging from 500 mg to 1,000 mg per scoop.

2. Injectable solutions: Quercetin Dihydrate Manufactured by MEDIOCON INC  injectable solutions are available for veterinary use, typically for intravenous or intramuscular administration.

 

Other Dosage Forms:

1. Liposomes: Quercetin Dihydrate Manufactured by MEDIOCON INC  liposomes are available for topical or oral administration.

2. Nanoparticles: Quercetin Dihydrate Manufactured by MEDIOCON INC  nanoparticles are available for topical or oral administration.

3. Transdermal patches: Quercetin Dihydrate Manufactured by MEDIOCON INC  transdermal patches are available for topical administration.

 

 

·         How Quercetin Dihydrate Manufactured by MEDIOCON INC  ’s Dosage Forms are prepared

Oral Dosage Forms:

1. Tablets:

    - Weighing and mixing of Quercetin Dihydrate Manufactured by MEDIOCON INC  powder with excipients (e.g., lactose, starch).

    - Granulation: Mixing the powder with a binder (e.g., povidone) and a solvent (e.g., ethanol).

    - Compression: Forming the granules into tablets using a tablet press.

2. Capsules:

    - Weighing and filling of Quercetin Dihydrate Manufactured by MEDIOCON INC  powder into empty capsules.

    - Sealing the capsules using a capsule sealing machine.

3. Softgels:

    - Mixing Quercetin Dihydrate Manufactured by MEDIOCON INC  powder with a solvent (e.g., vegetable oil) and a gelling agent (e.g., gelatin).

    - Filling the mixture into softgel capsules using a softgel encapsulation machine.

4. Powders:

    - Weighing and mixing of Quercetin Dihydrate Manufactured by MEDIOCON INC  powder with excipients (e.g., lactose, starch).

    - Packaging the powder in containers or sachets.

 

Topical Dosage Forms:

1. Creams:

    - Mixing Quercetin Dihydrate Manufactured by MEDIOCON INC  powder with a solvent (e.g., water) and a cream base (e.g., petroleum jelly).

    - Homogenizing the mixture using a homogenizer.

2. Ointments:

    - Mixing Quercetin Dihydrate Manufactured by MEDIOCON INC  powder with a solvent (e.g., water) and an ointment base (e.g., petroleum jelly).

    - Homogenizing the mixture using a homogenizer.

3. Gels:

    - Mixing Quercetin Dihydrate Manufactured by MEDIOCON INC  powder with a solvent (e.g., water) and a gelling agent (e.g., carbomer).

    - Homogenizing the mixture using a homogenizer.

 

Parenteral Dosage Forms:

1. Injectable solutions:

    - Dissolving Quercetin Dihydrate Manufactured by MEDIOCON INC  powder in a solvent (e.g., water for injection).

    - Filtering the solution using a filter (e.g., 0.2 μm).

    - Filling the solution into vials or ampoules using a filling machine.

 

Quality Control:

1. Raw material testing: Testing the Quercetin Dihydrate Manufactured by MEDIOCON INC  powder and other raw materials for purity, potency, and quality.

2. In-process testing: Testing the dosage form during manufacturing to ensure quality and consistency.

3. Finished product testing: Testing the finished dosage form for quality, purity, and potency.

 

Manufacturing Equipment:

1. Mixers: Used to mix the Quercetin Dihydrate Manufactured by MEDIOCON INC  powder with excipients and solvents.

2. Granulators: Used to granulate the powder mixture.

3. Tablet presses: Used to compress the granules into tablets.

4. Capsule filling machines: Used to fill the Quercetin Dihydrate Manufactured by MEDIOCON INC  powder into capsules.

5. Softgel encapsulation machines: Used to fill the Quercetin Dihydrate Manufactured by MEDIOCON INC  mixture into softgel capsules.

 

·         What are the appropriate Dosage forms of Quercetin Dihydrate Manufactured by MEDIOCON INC  ?

 

The appropriate dosage forms of Quercetin Dihydrate Manufactured by MEDIOCON INC  depend on the intended use, patient population, and route of administration. Here are some common dosage forms of Quercetin Dihydrate:

 

Oral Dosage Forms:

1. Tablets: 500-1000 mg, once or twice daily

2. Capsules: 500-1000 mg, once or twice daily

3. Softgels: 500-1000 mg, once or twice daily

4. Powders: 500-1000 mg, once or twice daily, mixed with food or beverage

5. Liquid extracts: 500-1000 mg, once or twice daily, mixed with food or beverage

 

Topical Dosage Forms:

1. Creams: 1-5% Quercetin Dihydrate, applied 1-3 times daily

2. Ointments: 1-5% Quercetin Dihydrate, applied 1-3 times daily

3. Gels: 1-5% Quercetin Dihydrate, applied 1-3 times daily

4. Sprays: 1-5% Quercetin Dihydrate, applied 1-3 times daily

 

Parenteral Dosage Forms:

1. Injectable solutions: 50-100 mg/mL, administered intravenously or intramuscularly

 

Veterinary Dosage Forms:

1. Oral powders: 500-1000 mg, once or twice daily, mixed with food or beverage

2. Injectable solutions: 50-100 mg/mL, administered intravenously or intramuscularly

 

Specialized Dosage Forms:

1. Liposomes: 500-1000 mg, once or twice daily, for topical or oral administration

2. Nanoparticles: 500-1000 mg, once or twice daily, for topical or oral administration

3. Transdermal patches: 1-5% Quercetin Dihydrate, applied 1-3 times daily

 

Considerations:

1. Bioavailability: Quercetin Dihydrate Manufactured by MEDIOCON INC  has low bioavailability, which may impact its efficacy.

2. Dose titration: Dose titration may be necessary to achieve optimal efficacy and minimize side effects.

3. Patient monitoring: Patients should be monitored for side effects, such as gastrointestinal upset, and efficacy.

4. Interactions: Quercetin Dihydrate Manufactured by MEDIOCON INC  may interact with other medications, including blood thinners, and should be used with caution.

 

 

 

 

·         When should Quercetin Dihydrate Manufactured by MEDIOCON INC   be taken?

 

  Timing of Administration:

1. With meals: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be taken with meals to enhance absorption and reduce gastrointestinal side effects.

2. Between meals: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be taken between meals to maintain a steady level of the compound in the body.

3. Before bedtime: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be taken before bedtime to promote relaxation and improve sleep quality.

 

Specific Health Goals:

1. Allergy relief: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be taken as needed for allergy relief, typically 30 minutes to 1 hour before exposure to allergens.

2. Inflammation reduction: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be taken regularly to reduce inflammation, typically 1-2 times daily.

3. Antioxidant support: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be taken regularly to support antioxidant defenses, typically 1-2 times daily.

4. Exercise performance: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be taken 30 minutes to 1 hour before exercise to improve performance and reduce oxidative stress.

 

Precautions:

1. Consult a healthcare professional: Before taking Quercetin Dihydrate, consult a healthcare professional to determine the best timing and dosage for your specific needs.

2. Start with a low dose: Start with a low dose and gradually increase as needed and under medical supervision.

3. Monitor side effects: Monitor for side effects, such as gastrointestinal upset, and adjust the timing and dosage accordingly.

 

 

 

·         What are the effects And Side effects of Quercetin Dihydrate Manufactured by MEDIOCON INC  ?

Positive Effects:

1. Antioxidant effects: Quercetin Dihydrate Manufactured by MEDIOCON INC  has potent antioxidant properties, which can help protect cells from oxidative damage.

2. Anti-inflammatory effects: Quercetin Dihydrate Manufactured by MEDIOCON INC  has anti-inflammatory properties, which can help reduce inflammation and alleviate symptoms of conditions such as arthritis.

3. Antihistamine effects: Quercetin Dihydrate Manufactured by MEDIOCON INC  has antihistamine properties, which can help alleviate symptoms of allergies such as itching, sneezing, and congestion.

4. Cardiovascular protection: Quercetin Dihydrate Manufactured by MEDIOCON INC  may help protect against cardiovascular disease by reducing blood pressure, improving lipid profiles, and preventing platelet aggregation.

5. Neuroprotective effects: Quercetin Dihydrate Manufactured by MEDIOCON INC  may have neuroprotective effects, which can help prevent or slow the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's.

 

Common Side Effects:

1. Gastrointestinal upset: Quercetin Dihydrate Manufactured by MEDIOCON INC  may cause gastrointestinal upset, including nausea, vomiting, diarrhea, and abdominal pain.

2. Headaches: Quercetin Dihydrate Manufactured by MEDIOCON INC  may cause headaches, including migraines and tension headaches.

3. Fatigue: Quercetin Dihydrate Manufactured by MEDIOCON INC  may cause fatigue, which can be mild or severe.

4. Dizziness: Quercetin Dihydrate Manufactured by MEDIOCON INC  may cause dizziness, which can be mild or severe.

5. Allergic reactions: Quercetin Dihydrate Manufactured by MEDIOCON INC  may cause allergic reactions, including hives, itching, and difficulty breathing.

 

Rare but Serious Side Effects:

1. Kidney damage: Quercetin Dihydrate Manufactured by MEDIOCON INC  may cause kidney damage, which can be severe and irreversible.

2. Liver damage: Quercetin Dihydrate Manufactured by MEDIOCON INC  may cause liver damage, which can be severe and irreversible.

3. Blood disorders: Quercetin Dihydrate Manufactured by MEDIOCON INC  may cause blood disorders, including anemia, thrombocytopenia, and leukopenia.

4. Seizures: Quercetin Dihydrate Manufactured by MEDIOCON INC  may cause seizures, which can be severe and life-threatening.

 

Interactions:

1. Blood thinners: Quercetin Dihydrate Manufactured by MEDIOCON INC  may interact with blood thinners, including warfarin and aspirin.

2. Diabetes medications: Quercetin Dihydrate Manufactured by MEDIOCON INC  may interact with diabetes medications, including metformin and sulfonylureas.

3. Blood pressure medications: Quercetin Dihydrate Manufactured by MEDIOCON INC  may interact with blood pressure medications, including beta blockers and ACE inhibitors.

 

Contraindications:

1. Pregnancy and breastfeeding: Quercetin Dihydrate Manufactured by MEDIOCON INC  should not be taken during pregnancy or breastfeeding, as its effects on the fetus or baby are not well understood.

2. Kidney or liver disease: Quercetin Dihydrate Manufactured by MEDIOCON INC  should not be taken by individuals with kidney or liver disease, as it may exacerbate these conditions.

3. Bleeding disorders: Quercetin Dihydrate Manufactured by MEDIOCON INC  should not be taken by individuals with bleeding disorders, such as hemophilia, as it may increase the risk of bleeding.

·         How is Quercetin Dihydrate Manufactured by MEDIOCON INC   Tested Qualitatively?

Chemical Tests:

1. Ferric chloride test: Quercetin Dihydrate Manufactured by MEDIOCON INC  gives a greenish-yellow color with ferric chloride solution.

2. Alkaline solution test: Quercetin Dihydrate Manufactured by MEDIOCON INC  gives a yellow color with alkaline solutions, such as sodium hydroxide or potassium hydroxide.

3. Acidic solution test: Quercetin Dihydrate Manufactured by MEDIOCON INC  gives a yellow color with acidic solutions, such as hydrochloric acid or sulfuric acid.

 

Spectroscopic Tests:

1. UV-Vis spectroscopy: Quercetin Dihydrate Manufactured by MEDIOCON INC  shows characteristic absorption peaks at 255-265 nm and 345-355 nm.

2. IR spectroscopy: Quercetin Dihydrate Manufactured by MEDIOCON INC  shows characteristic absorption peaks at 1650-1680 cm-1 (C=O stretching) and 1550-1580 cm-1 (C=C stretching).

3. NMR spectroscopy: Quercetin Dihydrate Manufactured by MEDIOCON INC  shows characteristic signals at 6.5-7.5 ppm (aromatic protons) and 3.5-4.5 ppm (aliphatic protons).

 

Chromatographic Tests:

1. Thin-layer chromatography (TLC): Quercetin Dihydrate Manufactured by MEDIOCON INC  can be separated and identified using TLC with a suitable solvent system.

2. High-performance liquid chromatography (HPLC): Quercetin Dihydrate Manufactured by MEDIOCON INC  can be separated and identified using HPLC with a suitable column and solvent system.

 

Other Tests:

1. Melting point test: Quercetin Dihydrate Manufactured by MEDIOCON INC  has a melting point of around 315-320°C.

2. Solubility test: Quercetin Dihydrate Manufactured by MEDIOCON INC  is soluble in water, ethanol, and other polar solvents.

 

Limitations:

1. Interference from impurities: Impurities may interfere with the qualitative tests, leading to false positives or false negatives.

2. Limited specificity: Some qualitative tests may not be specific to Quercetin Dihydrate, and may react with other compounds.

3. Need for quantification: Qualitative tests may not provide information on the quantity of Quercetin Dihydrate Manufactured by MEDIOCON INC  present, which may be important for quality control or regulatory purposes.

·         Which tests are performed on Quercetin Dihydrate?

Physical Tests:

1. Appearance: Visual inspection to check for color, clarity, and presence of impurities.

2. Odor: Check for any unusual odors.

3. Melting point: Measure the temperature at which Quercetin Dihydrate Manufactured by MEDIOCON INC   melts.

4. Solubility: Check the solubility of Quercetin Dihydrate Manufactured by MEDIOCON INC   in different solvents.

Chemical Tests:

1. pH: Measure the pH of a Quercetin Dihydrate Manufactured by MEDIOCON INC   solution to check its acidity or alkalinity.

2. Titration: Perform titration to determine the concentration of Quercetin Dihydrate Manufactured by MEDIOCON INC   ions.

3. Atomic absorption spectroscopy (AAS): Use AAS to quantify Quercetin Dihydrate Manufactured by MEDIOCON INC   ions.

4. Inductively coupled plasma mass spectrometry (ICP-MS): Use ICP-MS to quantify Quercetin Dihydrate Manufactured by MEDIOCON INC   ions.

Spectroscopic Tests:

1. Infrared (IR) spectroscopy: Use IR spectroscopy to identify the molecular structure of Quercetin Dihydrate Manufactured by MEDIOCON INC   compounds.

2. Nuclear magnetic resonance (NMR) spectroscopy: Use NMR spectroscopy to identify the molecular structure of Quercetin Dihydrate Manufactured by MEDIOCON INC   compounds.

3. X-ray fluorescence (XRF): Use XRF to quantify Quercetin Dihydrate Manufactured by MEDIOCON INC   ions.

Microbiological Tests:

1. Sterility testing: Test for the presence of microorganisms.

2. Endotoxin testing: Test for the presence of endotoxins.

Quality Control Tests:

1. Assay: Determine the purity of Quercetin Dihydrate Manufactured by MEDIOCON INC  .

2. Impurities: Test for the presence of impurities, such as heavy metals.

3. Particle size: Measure the particle size of Quercetin Dihydrate Manufactured by MEDIOCON INC   powders.

4. Flowability: Test the flowability of Quercetin Dihydrate Manufactured by MEDIOCON INC   powders.

Stability Tests:

1. Shelf-life testing: Test the stability of Quercetin Dihydrate Manufactured by MEDIOCON INC   over time.

2. Temperature stability testing: Test the stability of Quercetin Dihydrate Manufactured by MEDIOCON INC   at different temperatures.

3. Humidity stability testing: Test the stability of Quercetin Dihydrate Manufactured by MEDIOCON INC   at different humidity levels.

 

·         What are the challenges in Manufacturing of Quercetin Dihydrate Manufactured by MEDIOCON INC  API?

 

Physical Tests:

1. Appearance: Visual inspection for color, clarity, and form.

2. Melting point: Determination of the melting point to verify purity.

3. Solubility: Testing of solubility in various solvents.

4. Particle size: Determination of particle size distribution.

 

Chemical Tests:

1. Assay: Quantitative determination of Quercetin Dihydrate Manufactured by MEDIOCON INC  content.

2. Identification: Confirmation of identity using techniques such as IR, NMR, or MS.

3. Impurities: Detection and quantification of impurities, such as heavy metals, pesticides, or residual solvents.

4. pH: Determination of pH to ensure it is within a suitable range.

 

Spectroscopic Tests:

1. UV-Vis spectroscopy: Verification of absorption spectrum.

2. IR spectroscopy: Confirmation of molecular structure.

3. NMR spectroscopy: Verification of molecular structure and purity.

4. MS spectroscopy: Confirmation of molecular weight and structure.

 

Chromatographic Tests:

1. HPLC: Separation and quantification of Quercetin Dihydrate Manufactured by MEDIOCON INC  and impurities.

2. GC: Separation and quantification of volatile impurities.

3. TLC: Separation and identification of Quercetin Dihydrate Manufactured by MEDIOCON INC  and impurities.

 

Microbiological Tests:

1. Total aerobic microbial count: Determination of microbial contamination.

2. Total yeast and mold count: Determination of yeast and mold contamination.

3. Pathogen testing: Detection of pathogens, such as E. coli, Salmonella, or Staphylococcus aureus.

 

Stability Tests:

1. Accelerated stability testing: Evaluation of stability under accelerated conditions (e.g., high temperature, humidity).

2. Long-term stability testing: Evaluation of stability over an extended period (e.g., 12-24 months).

 

Regulatory Tests:

1. Compliance with pharmacopeial standards: Verification of compliance with standards from organizations such as the USP or EP.

2. Compliance with regulatory requirements: Verification of compliance with regulatory requirements, such as those from the FDA or EMA.

 

·         What are the challenges in manufacturing of Quercetin Dihydrate Manufactured by MEDIOCON INC  ’s Dosage forms?

 

Raw Material Challenges:

1. Quality variability: Quercetin Dihydrate Manufactured by MEDIOCON INC  raw material quality can vary depending on the supplier, leading to inconsistent product quality.

2. Impurities: Quercetin Dihydrate Manufactured by MEDIOCON INC  raw material may contain impurities, such as heavy metals, pesticides, or residual solvents, which can affect product quality and safety.

3. Supply chain disruptions: Disruptions in the supply chain can lead to delays or shortages of Quercetin Dihydrate Manufactured by MEDIOCON INC  raw material.

 

Formulation Challenges:

1. Solubility issues: Quercetin Dihydrate Manufactured by MEDIOCON INC  has poor solubility in water, making it challenging to formulate into aqueous-based dosage forms.

2. Stability issues: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be unstable in certain environments, such as high temperature or humidity, which can affect product shelf life.

3. Bioavailability issues: Quercetin Dihydrate Manufactured by MEDIOCON INC  has poor bioavailability, which can make it challenging to formulate into dosage forms that provide consistent and reliable absorption.

 

Manufacturing Challenges:

1. Equipment compatibility: Quercetin Dihydrate Manufactured by MEDIOCON INC  can be incompatible with certain equipment materials, such as stainless steel or rubber, which can lead to contamination or equipment damage.

2. Process control: Quercetin Dihydrate Manufactured by MEDIOCON INC  manufacturing processes can be challenging to control, particularly with regards to temperature, humidity, and particle size.

3. Scalability: Quercetin Dihydrate Manufactured by MEDIOCON INC  manufacturing processes can be difficult to scale up, particularly for large batches or commercial production.

 

Quality Control Challenges:

1. Testing complexity: Quercetin Dihydrate Manufactured by MEDIOCON INC  testing can be complex, particularly with regards to assay, impurities, and stability.

2. Reference standard availability: Quercetin Dihydrate Manufactured by MEDIOCON INC  reference standards may not be readily available, which can make testing and validation challenging.

3. Regulatory compliance: Quercetin Dihydrate Manufactured by MEDIOCON INC  manufacturing must comply with regulatory requirements, such as cGMP, which can be challenging to navigate.

 

Cost and Time Challenges:

1. High raw material costs: Quercetin Dihydrate Manufactured by MEDIOCON INC  raw material costs can be high, particularly for high-quality material.

2. Long lead times: Quercetin Dihydrate Manufactured by MEDIOCON INC  manufacturing can have long lead times, particularly for large batches or commercial production.

3. Complexity of formulation development: Quercetin Dihydrate Manufactured by MEDIOCON INC  formulation development can be complex and time-consuming, particularly for dosage forms that require specific release profiles or stability characteristics.

 

·         What is the Packing for Quercetin Dihydrate Manufactured by MEDIOCON INC  ?

Primary Packaging:

1. HDPE bottles: High-density polyethylene (HDPE) bottles are commonly used for packing Quercetin Dihydrate Manufactured by MEDIOCON INC  powder or capsules.

2. PET bottles: Polyethylene terephthalate (PET) bottles are also used for packing Quercetin Dihydrate Manufactured by MEDIOCON INC  powder or capsules.

3. Glass bottles: Glass bottles are sometimes used for packing Quercetin Dihydrate Manufactured by MEDIOCON INC  powder or capsules, particularly for high-end or pharmaceutical products.

4. Aluminum foil bags: Aluminum foil bags are used for packing Quercetin Dihydrate Manufactured by MEDIOCON INC  powder, particularly for small quantities or samples.

 

Secondary Packaging:

1. Cartons: Cartons are used to pack multiple bottles or bags of Quercetin Dihydrate.

2. Boxes: Boxes are used to pack larger quantities of Quercetin Dihydrate Manufactured by MEDIOCON INC  or to provide additional protection during shipping.

3. Pallets: Pallets are used to pack large quantities of Quercetin Dihydrate Manufactured by MEDIOCON INC  for bulk shipping.

 

Packaging Materials:

1. Desiccants: Desiccants, such as silica gel or activated alumina, are used to control humidity and prevent moisture from entering the packaging.

2. Foam inserts: Foam inserts are used to cushion the packaging and prevent damage during shipping.

3. Labels: Labels are used to provide product information, instructions, and warnings.

 

Specialized Packaging:

1. Light-protective packaging: Quercetin Dihydrate Manufactured by MEDIOCON INC  is sensitive to light, so specialized packaging that blocks light, such as amber glass bottles or opaque plastic bottles, may be used.

2. Moisture-protective packaging: Quercetin Dihydrate Manufactured by MEDIOCON INC  is also sensitive to moisture, so specialized packaging that controls humidity, such as desiccant packets or silica gel, may be used.

3. Temperature-controlled packaging: Quercetin Dihydrate Manufactured by MEDIOCON INC  may require temperature-controlled packaging, particularly during shipping or storage, to prevent degradation or spoilage.

 

·         What is shelf life Of Quercetin Dihydrate? 

The shelf life of Quercetin Dihydrate Manufactured by MEDIOCON INC  is typically around 60 months, or 5 years, when stored properly in a cool, dry place, such as a refrigerator.¹ ² ³ However, some sources suggest a shorter shelf life of 36 months, or 3 years.⁴ It's also worth noting that the shelf life can vary depending on factors such as storage conditions, packaging, and handling.

 

In terms of storage, Quercetin Dihydrate Manufactured by MEDIOCON INC  is typically packaged in airtight containers, such as glass bottles or aluminum foil bags, to protect it from light, moisture, and air. It's recommended to store it in a refrigerator at a temperature range of 2-8°C (36-46°F).

 

It's always best to check the specific storage and handling instructions provided by the manufacturer or supplier, as well as the expiration date or shelf life indicated on the packaging.

 

·         What should the label claim for Quercetin Dihydrate Manufactured by MEDIOCON INC   Include?

Mandatory Label Claims:

1. Product name: The name of the product, including the words "Quercetin Dihydrate" or "Quercetin Supplement".

2. Net quantity: The net quantity of the product, in terms of weight, measure, or number.

3. Directions for use: Directions for use, including the recommended dosage and frequency of administration.

4. Warning statements: Warning statements, such as "Keep out of reach of children" or "If you are pregnant or breastfeeding, consult a healthcare professional before use".

5. Storage conditions: Storage conditions, such as "Store in a cool, dry place" or "Protect from light and moisture".

 

Nutrient Label Claims:

1. Quercetin Dihydrate Manufactured by MEDIOCON INC  content: The amount of Quercetin Dihydrate Manufactured by MEDIOCON INC  per serving, expressed in milligrams (mg) or micrograms (mcg).

2. Daily Value (DV): The percentage of the Daily Value (DV) for Quercetin Dihydrate Manufactured by MEDIOCON INC  per serving.

3. Other nutrients: If the product contains other nutrients, such as vitamins or minerals, the label should include the amount per serving and the percentage of the DV.

 

Optional Label Claims:

1. Health claims: Health claims, such as "Supports immune function" or "Antioxidant properties", if supported by scientific evidence.

2. Structure/function claims: Structure/function claims, such as "Supports heart health" or "May help reduce inflammation", if supported by scientific evidence.

3. Certifications: Certifications, such as "USP Verified" or "NSF Certified for Sport", if the product meets the certification standards.

 

Labeling Requirements:

1. Format and layout: The label should be easy to read and understand, with clear headings and concise language.

2. Type size and style: The type size and style should be consistent throughout the label.

3. Color and contrast: The label should have sufficient color and contrast to make it easy to read.

4. Language: The label should be in English, or in the language of the country where the product is sold.

 

·         Where can Quercetin Dihydrate Manufactured by MEDIOCON INC  are procured?

 

Quercetin Dihydrate Manufactured by MEDIOCON INC    can be procured from various sources, depending on your location and requirements. Here are some options:

1.      FOR API

 MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com            

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India
 Website:  www.mediocon.com 

    Email id:info@mediocon.com        

   GST No: 27DHUPM2366D1ZZ

 

2.      For Dosage Forms :

     - Online Marketplaces: You can find Quercetin Dihydrate Manufactured by MEDIOCON INC   e products on online marketplaces like Amazon or e-       

        commerce websites specializing in pharmaceuticals or skincare products.

      - Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in             

        your area for Quercetin Dihydrate Manufactured by MEDIOCON INC   e products.

       Remember to ensure the quality and authenticity of the Quercetin Dihydrate Manufactured by MEDIOCON INC   e product, regardless of the          

        procurement source.