Nobiletin 478-01-3 Manufacturer Exporter MEDIOCON INC

 

Nobiletin  Manufactured by MEDIOCON INC     

 

·   Name: Nobiletin

 

·      CAS No:  478-01-3

 

 

·   Molecular Weight: 402.39g/mol

 

·   Molecular formula: C₂₁H₂₂O₈

 

·   Synonyms: 3',4',5,6,7,8-hexamethoxyflavone and 5,6,7,8,3',4'-hexamethoxyflavone

 

                                                        

·   Appearance:  white to light yellow powder or crystal.

 

Solubility :  poor solubility in water but is soluble in organic solvents like ethanol, DMSO, and DMF.

                  

·   Use :

                                                                   

Nobiletin is a flavonoid compound found in citrus fruits, particularly in the peels of oranges and tangerines. It has been studied for its potential health benefits, including:

 

Potential Health Benefits:

1. Antioxidant properties: Nobiletin has been shown to have antioxidant effects, which can help protect against cell damage and oxidative stress.

2. Anti-inflammatory effects: Nobiletin may have anti-inflammatory properties, which could help reduce inflammation and alleviate symptoms associated with various conditions.

3. Cancer prevention: Some studies suggest that nobiletin may have anti-cancer effects, although more research is needed to confirm this.

4. Neuroprotective effects: Nobiletin may have neuroprotective properties, which could help protect against neurodegenerative diseases such as Alzheimer's and Parkinson's.

 

Potential Uses:

1. Dietary supplement: Nobiletin is sometimes used as a dietary supplement, often in combination with other flavonoids or nutrients.

2. Pharmaceutical applications: Nobiletin's potential therapeutic effects make it a compound of interest for pharmaceutical research and development.

 

Considerations:

1. More research needed: While nobiletin shows promise, more research is needed to fully understand its effects and potential benefits.

2. Consult a healthcare professional: Before using nobiletin supplements or extracts, consult with a healthcare professional to discuss potential interactions or side effects.

 

·      How is Nobiletin  manufactured by MEDIOCON INC Synthesized?

 

Nobiletin can be synthesized through various methods, including:

 

Chemical Synthesis:

1. Flavonoid synthesis: Nobiletin can be synthesized using flavonoid synthesis pathways, involving the formation of the flavone backbone and subsequent methylation and hydroxylation reactions.

2. Organic synthesis: Nobiletin can be synthesized through organic synthesis methods, involving the use of various reagents and catalysts to form the desired compound.

 

Extraction and Purification:

1. Citrus peel extraction: Nobiletin can be extracted from citrus peels using solvents such as ethanol or acetone.

2. Purification: The extracted nobiletin can be purified using techniques such as chromatography or crystallization.

 

Biotechnological Approaches:

1. Microbial fermentation: Nobiletin can be produced through microbial fermentation using genetically engineered microorganisms.

2. Enzymatic synthesis: Nobiletin can be synthesized using enzymes that catalyze the formation of the flavone backbone and subsequent modifications.

 

The choice of synthesis method depends on the desired yield, purity, and cost-effectiveness of the final product.

 

·   What are the different  dosage forms  of   Nobiletin  Manufactured  by  MEDIOCON INC?

 

Nobiletin can be formulated into various dosage forms, including:

 

Dietary Supplements:

1. Capsules: Nobiletin capsules can be used as a dietary supplement.

2. Tablets: Nobiletin tablets can be used as a convenient dosage form.

 

Extracts:

1. Standardized extracts: Standardized extracts of nobiletin can be used in dietary supplements or pharmaceutical applications.

 

Food Products:

1. Functional foods: Nobiletin can be added to functional foods, such as beverages or energy bars.

 

Pharmaceutical Dosage Forms:

1. Oral formulations: Nobiletin can be formulated into oral dosage forms, such as tablets or capsules, for potential therapeutic applications.

The choice of dosage form depends on the intended use, desired bioavailability, and target population.

 

·         How Nobiletin  Manufactured by MEDIOCON INC   Dosage Forms are prepared?

 

Nobiletin dosage forms can be prepared using various methods, including:

 

Preparation Methods:

1. Encapsulation: Nobiletin can be encapsulated in capsules using standard encapsulation techniques.

2. Tableting: Nobiletin can be compressed into tablets using tableting machines.

3. Extraction and formulation: Nobiletin extracts can be formulated into various dosage forms, such as capsules or tablets.

 

Formulation Considerations:

1. Excipient selection: Excipients, such as fillers, binders, and lubricants, are selected based on their compatibility with nobiletin and the desired dosage form.

2. Stability testing: Stability testing is performed to ensure the quality and potency of the nobiletin dosage form.

 

Manufacturing Process:

1. Weighing and mixing: Nobiletin and excipients are accurately weighed and mixed according to the formulation.

2. Granulation or blending: The mixture may undergo granulation or blending to ensure uniformity.

3. Tableting or encapsulation: The final dosage form is prepared using tableting or encapsulation equipment.

 

The preparation of nobiletin dosage forms requires careful consideration of formulation and manufacturing processes to ensure the quality and efficacy of the final product.

 

·         What are the appropriate Dosage forms of Nobiletin  Manufactured  by  MEDIOCON   INC?

The appropriate dosage forms of Nobiletin may include:

 

Oral Dosage Forms:

1. Capsules: Suitable for dietary supplements or pharmaceutical applications.

2. Tablets: Convenient for oral administration.

3. Softgels: May enhance bioavailability.

 

Considerations:

1. Bioavailability: Choose dosage forms that optimize bioavailability.

2. Stability: Ensure the dosage form maintains nobiletin's stability.

3. Patient compliance: Select dosage forms that are easy to administer and comply with.

 

The choice of dosage form depends on the intended use, desired bioavailability, and target population.

 

 

·         When should Nobiletin  Manufactured by MEDIOCON INC  be taken?

The optimal timing for taking Nobiletin may depend on various factors, including:

 

Meal Timing:

1. With meals: Taking Nobiletin with meals may enhance absorption.

2. On an empty stomach: Some studies suggest taking Nobiletin on an empty stomach may be beneficial.

 

Daily Routine:

1. Morning or evening: The timing of Nobiletin intake may depend on individual preferences and schedules.

 

Consult a Healthcare Professional:

1. Personalized advice: Consult with a healthcare professional to determine the best timing for taking Nobiletin based on individual needs and health status.

 

It's essential to follow the recommended dosage and timing instructions provided by a healthcare professional or the product label.

 

·         What are the effects And Side effects of Nobiletin  Manufactured by MEDIOCON INC?

Nobiletin may have various effects and potential side effects:

 

Potential Benefits:

1. Antioxidant effects: Nobiletin's antioxidant properties may help protect against cell damage.

2. Anti-inflammatory effects: Nobiletin may help reduce inflammation.

3. Neuroprotective effects: Nobiletin may have neuroprotective properties.

 

Potential Side Effects:

1. Gastrointestinal issues: Nausea, diarrhea, or stomach upset.

2. Allergic reactions: Rarely, some individuals may experience allergic reactions.

 

Interactions:

1. Medications: Nobiletin may interact with certain medications, such as blood thinners.

2. Other supplements: Nobiletin may interact with other supplements or nutrients.

 

Precautions:

1. Pregnancy and lactation: Consult a healthcare professional before taking Nobiletin during pregnancy or breastfeeding.

2. Underlying health conditions: Individuals with underlying health conditions should consult a healthcare professional before taking Nobiletin.

 

It's essential to consult with a healthcare professional before taking Nobiletin supplements or extracts.

 

·         How is Nobiletin  Manufactured by MEDIOCON  INC  Tested Qualitatively?

Nobiletin can be tested qualitatively using various analytical techniques:

 

Chemical Tests:

1. High-Performance Liquid Chromatography (HPLC): Separates and detects nobiletin.

2. Mass Spectrometry (MS): Confirms the molecular structure of nobiletin.

 

Instrumental Tests:

1. Nuclear Magnetic Resonance (NMR) Spectroscopy: Determines the molecular structure of nobiletin.

2. Infrared (IR) Spectroscopy: Identifies the functional groups present in Nobiletin.

 

Chromatographic Tests:

1. Thin-Layer Chromatography (TLC): Separates and identifies Nobiletin.

2. Gas Chromatography (GC): Analyzes the volatility and purity of Nobiletin.

 

These tests help ensure the identity, purity, and quality of Nobiletin.

 

·         Which tests are performed on Nobiletin  Manufactured by  MEDIOCON INC ?

Various tests can be performed on Nobiletin to ensure its quality, purity, and potency:

 

Physical Tests:

1. Appearance: Verifies the physical appearance, such as color and texture.

2. Solubility: Tests the solubility of Nobiletin in various solvents.

 

Chemical Tests:

1. HPLC (High-Performance Liquid Chromatography): Measures the purity and content of Nobiletin.

2. Mass Spectrometry (MS): Confirms the molecular structure of Nobiletin.

 

Instrumental Tests:

1. NMR (Nuclear Magnetic Resonance) Spectroscopy: Determines the molecular structure of Nobiletin.

2. IR (Infrared) Spectroscopy: Identifies the functional groups present in Nobiletin.

 

Quality Control Tests:

1. Purity testing: Ensures the purity of Nobiletin.

2. Stability testing: Evaluates the stability of Nobiletin under various conditions.

 

These tests help ensure the quality and consistency of Nobiletin for research, pharmaceutical, or dietary supplement applications.

 

·         What are the challenges in Manufacturing of Nobiletin  Manufactured by MEDIOCON   INC API?

The manufacturing of Nobiletin API (Active Pharmaceutical Ingredient) poses several challenges:

 

Chemical Challenges:

1. Complex synthesis: Nobiletin's complex molecular structure requires multi-step synthesis.

2. Impurity control: Controlling impurities is crucial to ensure the quality and purity of Nobiletin API.

 

Process Challenges:

1. Process optimization: Optimizing the manufacturing process is essential to ensure consistency and quality.

2. Scalability: Scaling up the manufacturing process while maintaining quality and consistency can be challenging.

 

Quality Control Challenges:

1. Purity testing: Ensuring the purity of Nobiletin API requires sensitive and specific analytical methods.

2. Stability testing: Evaluating the stability of Nobiletin API under various conditions is crucial.

 

Regulatory Challenges:

1. Compliance with GMP: Ensuring compliance with Good Manufacturing Practice (GMP) regulations is essential.

2. Documentation and validation: Maintaining detailed documentation and validating the manufacturing process are critical.

 

Addressing these challenges is essential to ensure the production of high-quality Nobiletin API.

 

·         What are the challenges in manufacturing of Nobiletin  Manufactured by MEDIOCON  INC ’s Dosage forms?

The manufacturing of Nobiletin dosage forms poses several challenges:

 

Formulation Challenges:

1. Solubility issues: Nobiletin's poor solubility may affect bioavailability.

2. Excipient selection: Choosing suitable excipients that are compatible with Nobiletin is crucial.

 

Manufacturing Challenges:

1. Process optimization: Optimizing the manufacturing process to ensure consistency and quality.

2. Scale-up: Scaling up the manufacturing process while maintaining quality and consistency.

 

Quality Control Challenges:

1. Content uniformity: Ensuring uniform distribution of Nobiletin in the dosage form.

2. Stability testing: Evaluating the stability of Nobiletin in the dosage form.

 

Regulatory Challenges:

1. Compliance with GMP: Ensuring compliance with Good Manufacturing Practice regulations.

2. Validation and documentation: Maintaining detailed documentation and validating the manufacturing process.

 

Other Challenges:

1. Bioavailability enhancement: Enhancing the bioavailability of Nobiletin to ensure efficacy.

2. Cost-effective production: Producing Nobiletin dosage forms in a cost-effective manner.

 

Addressing these challenges is essential to ensure the production of high-quality Nobiletin dosage forms.

 

·         What is the Packing for Nobiletin  Manufactured by MEDIOCON INC?

The packaging for Nobiletin may vary depending on the dosage form and intended use:

 

Packaging Options:

1. Bottles: Glass or plastic bottles with tight-fitting lids.

2. Blister packs: Individual dosage units packaged in blister packs.

3. Capsules or tablets containers: Containers specifically designed for capsules or tablets.

 

Packaging Considerations:

1. Light protection: Nobiletin may require protection from light.

2. Moisture control: Packaging should control moisture to maintain stability.

3. Tamper-evident: Packaging should be tamper-evident to ensure product integrity.

 

The packaging should ensure the stability, quality, and safety of Nobiletin during storage and transportation.

 

·         What is shelf life Of Nobiletin  Manufactured by MEDIOCON INC? 

 

The shelf life of Nobiletin can vary depending on several factors, including:

 

Storage Conditions:

1. Temperature: Nobiletin's stability may be affected by temperature.

2. Humidity: Moisture can impact Nobiletin's stability.

3. Light exposure: Light can also affect Nobiletin's stability.

 

Packaging and Formulation:

1. Packaging quality: The quality of packaging can impact shelf life.

2. Formulation: The formulation of Nobiletin can also impact its shelf life.

 

Typical Shelf Life:

The shelf life of Nobiletin can range from 2-5 years, depending on the specific product and storage conditions.

 

It's essential to check the product label or consult with the manufacturer for specific shelf life information.

 

·         What should the label claim for Nobiletin  Manufactured by MEDIOCON INC   Include?

 

The label claim for Nobiletin should include:

 

Essential Information:

1. Product name: The name of the product, including the ingredient Nobiletin.

2. Concentration: The amount of Nobiletin per serving or unit.

3. Serving size: The recommended serving size.

4. Directions for use: Instructions on how to use the product.

5. Storage conditions: Recommendations for storing the product.

 

Regulatory Information:

1. Regulatory compliance: Compliance with relevant regulatory requirements.

2. Warning statements: Any necessary warning statements or cautions.

 

Quality Control:

1. Purity: Information on the purity of Nobiletin.

2. Quality assurance: Assurance of the product's quality.

 

The label claim should be accurate, clear, and compliant with regulatory requirements.

 

·         Where can Nobiletin  Manufactured by MEDIOCON INC are procured?

Nobiletin  Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

1.      FOR API

 MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com            

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com            

 GST No: 27DHUPM2366D1ZZ

 

2.      For Dosage Forms :

     - Online Marketplaces: You can find Nobiletin  Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

 - Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in             

   your area for Nobiletin  Manufactured by MEDIOCON INC  products.

 Remember to ensure the quality and authenticity of the Nobiletin  Manufactured by MEDIOCON INC product, regardless of the procurement source.