Citicoline 987-78-0 Manufacturer Exporter MEDIOCON INC

 

 

Citicoline Manufactured by MEDIOCON INC     

 

   Name: Citicoline

 

   CAS No:  987-78-0

 

Molecular Weight: 488.32 g/mol

  Molecular formula:   C₁₄H₂₆N₄O₁₁P₂

 

Synonyms:  cytidine diphosphate-choline

Appearance:  White to  off white crystalline powder.

   Solubility :  Readily soluble in water.

    Use :

Citicoline, also known as CDP-choline or cytidine diphosphate-choline, is used for various purposes:

- Cognitive Enhancement: Improving memory, focus, and mental clarity.

- Neuroprotection: Supporting brain health and potentially aiding in recovery from stroke, traumatic brain injury, or neurodegenerative diseases.

- Neuroplasticity: Enhancing brain adaptability and function.

 

Some potential benefits of citicoline include:

- Improved cognitive function

- Enhanced memory and learning

- Increased focus and attention

- Neuroprotective effects

- Potential benefits for conditions like Alzheimer's disease, Parkinson's disease, and stroke recovery

Citicoline is available in various forms, including supplements, and is often used in combination with other ingredients to support brain health and cognitive function. Consult a healthcare professional before using Citicoline supplements.

 How is  Citicoline manufactured by MEDIOCON INC Synthesized?

Citicoline (CDP-choline) can be synthesized through various methods, including:

- Enzymatic synthesis: Utilizing enzymes like cytidine triphosphate synthetase and choline-phosphate cytidylyltransferase to catalyze the reaction.

- Chemical synthesis: Involving multi-step reactions to form the cytidine diphosphate-choline molecule.

- Fermentation: Using microorganisms like bacteria or yeast to produce citicoline through fermentation processes.

 

The synthesized citicoline can be further purified and processed into various forms, such as powders, capsules, or tablets, for use in dietary supplements or pharmaceutical applications.

What are the different  dosage forms  of   Citicoline Manufactured  by  MEDIOCON INC?

Citicoline is available in various dosage forms, including:

- Tablets: Oral tablets containing citicoline in a solid form.

- Capsules: Citicoline in capsule form, often containing powder or granules.

- Powders: Citicoline powder for oral consumption, often mixed with water or other liquids.

- Injectable solutions: Citicoline injections for intravenous or intramuscular administration, typically used in medical settings.

- Sublingual tablets or sprays: Citicoline formulations designed for sublingual absorption.

 

These dosage forms cater to different needs, preferences, and medical requirements. Consult a healthcare professional to determine the most suitable form and dosage for individual needs.

  How Citicoline Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Citicoline dosage forms are prepared through various processes, depending on the desired form:

- Tablets:

    - Weighing and mixing citicoline with excipients (e.g., binders, fillers)

    - Granulation (wet or dry) to improve flow and compression

    - Tableting using a tablet press

- Capsules:

    - Filling capsules with citicoline powder or granules

    - Ensuring uniform fill weight and content

- Powders:

    - Weighing and mixing citicoline with other ingredients (if applicable)

    - Filling powder containers or sachets

- Injectable solutions:

    - Dissolving citicoline in a suitable solvent (e.g., water, saline)

    - Sterilizing the solution through filtration or autoclaving

    - Filling vials or ampoules

- Sublingual tablets or sprays:

    - Preparing citicoline in a suitable form for sublingual absorption

    - Formulating with excipients to enhance stability and bioavailability

These processes involve careful consideration of factors like stability, bioavailability, and regulatory compliance to ensure the final product meets quality standards.

What are the appropriate Dosage forms of Citicoline Manufactured  by  MEDIOCON   INC?                

The appropriate dosage forms of Citicoline depend on the intended use, patient needs, and medical context. Common dosage forms include:

- Oral tablets or capsules: Suitable for cognitive enhancement, neuroprotection, and general health.

- Injectable solutions: Typically used in medical settings for acute conditions, such as stroke or traumatic brain injury.

- Sublingual tablets or sprays: May be used for rapid absorption and potential cognitive benefits.

 

The choice of dosage form should consider factors like:

- Bioavailability

- Onset of action

- Patient compliance

- Specific medical needs

 

Consult a healthcare professional to determine the most suitable dosage form and regimen for individual needs.

When should Citicoline Manufactured by MEDIOCON INC be taken?

Citicoline can be taken:

- With meals: To enhance absorption and minimize gastrointestinal side effects.

- In divided doses: Spreading doses throughout the day (e.g., morning and afternoon) may help maintain consistent levels.

- At the same time daily: Consistency can help establish a routine and optimize benefits.

The optimal timing may vary depending on individual needs and medical conditions. Consult a healthcare professional for personalized guidance on taking citicoline. 

What are the effects And Side effects of Citicoline Manufactured by MEDIOCON INC?

Effects:

1. Cognitive enhancement (improved memory, focus, and mental clarity)

2. Neuroprotection (supporting brain health and potentially aiding in recovery from brain injuries or diseases)

3. Increased dopamine and norepinephrine levels

4. Enhanced brain energy and function

 

Side Effects:

1. Generally well-tolerated

2. Possible side effects:

    1. Headache

    2. Insomnia

    3. Anxiety or jitteriness (rare)

    4. Gastrointestinal issues (e.g., nausea, diarrhea)

    5. Allergic reactions (rare)

 

Precautions:

1. Consult a healthcare professional before taking citicoline, especially if pregnant, breastfeeding, or taking medications.

2. Monitor blood pressure and potential interactions with other substances.

 

Individual results and side effects may vary. Consult a healthcare professional for personalized guidance.

  How is Citicoline Manufactured by MEDIOCON  INC  Tested Qualitatively?

Citicoline is typically tested qualitatively using:

- High-Performance Liquid Chromatography (HPLC): To identify and quantify citicoline and its impurities.

- Mass Spectrometry (MS): To confirm the molecular structure and detect any degradation products.

- Nuclear Magnetic Resonance (NMR) Spectroscopy: To verify the molecular structure and purity.

- Thin-Layer Chromatography (TLC): To detect impurities and verify identity.

These methods help ensure the quality, purity, and authenticity of citicoline products.

   Which tests are performed on Citicoline Manufactured by  MEDIOCON INC ?

Citicoline testing typically involves various analytical methods to ensure its quality, purity, and potency. Some common tests include:

- High-Performance Liquid Chromatography (HPLC): To quantify citicoline content and detect impurities.

- Mass Spectrometry (MS): To confirm molecular structure and identify potential degradation products.

- Purity Test: To ensure citicoline meets purity standards.

- Identity Test: To verify citicoline's chemical identity.

- Impurity Profile: To detect and quantify impurities.

- Assay: To determine citicoline content and potency.

- Stability Testing: To evaluate citicoline's stability under various conditions.

These tests help ensure citicoline products meet quality standards and regulatory requirements.

What are the challenges in Manufacturing of Citicoline Manufactured by MEDIOCON   INC API?

The manufacturing of Citicoline Active Pharmaceutical Ingredient (API) poses several challenges, including:

- Complex synthesis: Citicoline's synthesis involves multiple steps, requiring precise control and optimization.

- Purity and impurity control: Ensuring high purity and controlling impurities is crucial for API quality.

- Stability and degradation: Citicoline's stability can be affected by factors like temperature, humidity, and pH, requiring careful handling and storage.

- Regulatory compliance: Meeting regulatory requirements and standards for API quality, safety, and efficacy is essential.

- Scalability and cost-effectiveness: Scaling up production while maintaining quality and controlling costs can be challenging.

- Raw material sourcing: Ensuring the quality and consistency of raw materials is vital for API production.

 

These challenges require careful process optimization, quality control, and regulatory compliance to ensure the production of high-quality Citicoline API.

What are the challenges in manufacturing of Citicoline Manufactured by MEDIOCON  INC ’s Dosage forms?

The manufacturing of Citicoline dosage forms poses several challenges, including:

- Stability and degradation: Citicoline's sensitivity to moisture, temperature, and pH can affect its stability and potency.

- Formulation optimization: Developing a stable and bioavailable formulation that ensures consistent release and absorption.

- Excipient compatibility: Ensuring compatibility between citicoline and excipients to prevent interactions and degradation.

- Tableting or encapsulation issues: Overcoming challenges related to tablet compression, capsule filling, or powder flow.

- Regulatory compliance: Meeting regulatory requirements for quality, safety, and efficacy.

- Scalability and process validation: Scaling up production while maintaining quality and validating manufacturing processes.

- Quality control and assurance: Implementing robust quality control measures to ensure batch-to-batch consistency.

These challenges require careful formulation development, process optimization, and quality control to ensure the production of high-quality Citicoline dosage forms.

What is the Packing for Citicoline Manufactured by MEDIOCON INC?

Citicoline packaging typically involves:

- Tight, light-resistant containers: To protect from light and moisture.

- Airtight packaging: To maintain stability and prevent degradation.

- Desiccants or moisture-control packets: To control humidity and maintain a dry environment.

- Labeling and documentation: Clear labeling and documentation, including batch numbers, expiration dates, and storage instructions.

Specific packaging materials may include:

- Bottles (HDPE or glass): For tablets, capsules, or powders.

- Blister packs: For individual tablet or capsule protection.

- Sachets or pouches: For powder or granular forms.

- Specialized packaging: Depending on the specific product requirements and regulatory standards.

The packaging should ensure the stability, quality, and safety of the citicoline product throughout its shelf life.

What is shelf life Of Citicoline Manufactured by MEDIOCON INC? 

The shelf life of Citicoline typically ranges from:

- 2-3 years: Depending on the formulation, packaging, and storage conditions.

- Specific storage conditions: Such as cool, dry places (e.g., 15-30°C/59-86°F) and protection from light and moisture, can help maintain stability.

Shelf life may vary depending on:

- Product formulation: Different forms (e.g., tablets, capsules, powders) and excipients can affect stability.

- Packaging: Quality and type of packaging materials can impact shelf life.

- Storage conditions: Temperature, humidity, and light exposure can influence stability.

Check the product label or manufacturer's guidelines for specific shelf life information.

What should the label claim for Citicoline Manufactured by MEDIOCON INC   Include?

The label claim for Citicoline should include:

- Product name and description: Clearly stating the product name and description.

- Active ingredient: Specifying citicoline as the active ingredient and its amount per serving.

- Directions for use: Providing instructions on dosage, frequency, and any specific usage guidelines.

- Warning and precautions: Listing potential side effects, contraindications, and precautions.

- Storage conditions: Specifying storage requirements (e.g., temperature, humidity, light protection).

- Expiration date or shelf life: Indicating the product's shelf life or expiration date.

- Manufacturer's information: Including the manufacturer's name, address, and contact details.

- Regulatory compliance: Complying with relevant regulatory requirements and standards.

This information helps ensure safe and effective use of the product.

Where can Citicoline Manufactured by MEDIOCON INC are procured?

Citicoline Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Citicoline Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Citicoline Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Citicoline Manufactured by MEDIOCON INC product, regardless of the procurement source.