Gentian Root Extract 72968-42-4 Manufacturer Exporter MEDIOCON INC

 

 

Gentian Root Extract Manufactured by MEDIOCON INC     

 

   Name: Gentian Root Extract

 

   CAS No: 72968-42-4

 

Molecular Weight:  NA

 

  Molecular formula:   NA

 

Synonyms:  Yellow Gentian Root Extract, Gentiana lutea Root Extract, and Pale           

Gentian Root Extract

Appearance:  light brown to yellowish-white powder or a light to medium amber        

                           liquid.

Solubility:   water-soluble or more soluble in other solvents like ethanol or propylene      

                      glycol

 

    Use :

Gentian root extract is used for various purposes, including:

- Digestive issues: Stimulates digestive enzymes, improving digestion and appetite.

- Appetite stimulation: Traditionally used to enhance appetite and alleviate digestive discomfort.

- Liver and gallbladder support: May support liver and gallbladder function.

- Antimicrobial and anti-inflammatory: Exhibits antimicrobial and anti-inflammatory properties.

- Traditional medicine: Used in herbal medicine for various ailments, including digestive issues and fever.

Gentian root extract is commonly found in:

- Digestive supplements: Capsules, tablets, or liquids supporting digestive health.

- Appetite stimulants: Products designed to enhance appetite and improve digestion.

- Herbal teas: Teas or infusions made from gentian root.

Some potential benefits include:

- Improved digestion: Enhanced digestive enzyme activity.

- Increased appetite: Stimulated appetite in individuals with digestive issues.

- Antimicrobial effects: Potential antimicrobial properties against certain pathogens.

As with any supplement, consult a healthcare professional before using gentian root extract, especially if you have underlying health conditions or take medications.

      How is Gentian Root Extract manufactured by MEDIOCON INC Synthesized?

Gentian root extract is typically obtained through various extraction methods, rather than synthesis. Common methods include:

- Solvent extraction: Using solvents like ethanol or water to extract bioactive compounds.

- Cold pressing: Mechanical extraction of compounds from the root.

- Infusion or decoction: Steeping the root in hot water to release active compounds.

- Maceration: Soaking the root in a solvent to extract compounds.

 

The resulting extract can be further processed through:

- Concentration: Removing excess solvent or water to create a concentrated extract.

- Purification: Removing impurities or unwanted compounds.

- Standardization: Adjusting the extract to a specific concentration of active compounds.

 

The choice of extraction method depends on the desired compounds, product application, and manufacturer preferences.

What are the different  dosage forms  of   Gentian Root Extract Manufactured  by  MEDIOCON INC?

Gentian root extract comes in various dosage forms to cater to different needs:

 

- Dry Extract: Available in capsules, with a typical dosage of 480-720 mg per day, divided into 2-3 doses.

- Tincture: Usually taken 3 times a day, with a recommended dosage of 10-20 drops in water or 3 ml per day.

- Powder: Can be taken in capsules, with a typical dosage of 500 mg to 1 g, 3 times a day, or 2-4 g per day.

- Tablets: Available with standardized dosages, taken according to the manufacturer's instructions.

- Tea: Steep 1-2 teaspoons of dried gentian root in boiling water for 3-10 minutes, taken 3 times a day before meals.

- Liquid Extracts: Dosage varies, but typically 0.5-1.5 ml, 3 times a day.

- Homeopathic Mother Tincture: Used for digestive disorders, weakness, and convalescence.

 

When using gentian root extract, consider the following guidelines¹ ² ³:

- Take it before meals to aid digestion and stimulate appetite.

- Consult a healthcare professional before using gentian root extract, especially if you have underlying health conditions or take medications.

- Be cautious of potential interactions with medications, such as antihypertensive drugs.

- Avoid using gentian root extract if you have stomach ulcers, gastritis, or are pregnant/breastfeeding due to insufficient safety data.

  How Gentian Root Extract Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Gentian root extract dosage forms are prepared through various processes:

- Dry Extract: Gentian roots are dried, ground, and extracted using solvents like ethanol or water. The extract is then dried to a powder and filled into capsules or tablets.

- Tincture: Gentian roots are soaked in a solvent, typically ethanol or glycerin, to extract the active compounds. The resulting liquid is then filtered and bottled.

- Powder: Gentian roots are dried, ground into a fine powder, and filled into capsules or used to make tablets.

- Tablets: Gentian root extract powder is mixed with excipients, compressed into tablets, and coated if necessary.

- Tea: Dried gentian roots are steeped in hot water to release the active compounds, and the resulting tea is consumed.

- Liquid Extracts: Gentian roots are extracted using solvents, and the resulting liquid is filtered, concentrated, and bottled.

The preparation process typically involves:

1. Raw material sourcing: Sourcing high-quality gentian roots.

2. Cleaning and drying: Cleaning and drying the roots to remove impurities.

3. Extraction: Extracting the active compounds using solvents or other methods.

4. Filtration: Filtering the extract to remove impurities.

5. Concentration: Concentrating the extract to the desired potency.

6. Formulation: Mixing the extract with excipients to create the desired dosage form.

7. Quality control: Testing the final product for quality, purity, and potency.

The specific preparation process may vary depending on the manufacturer and the desired dosage form.

What are the appropriate Dosage forms of Gentian Root Extract Manufactured  by  MEDIOCON   INC?                

The appropriate dosage forms of Gentian root extract include:

- Capsules: 400-500 mg, 2-3 times a day, before meals

- Tincture: 10-20 drops in water, 3 times a day

- Tablets: Follow manufacturer's instructions for standardized dosages

- Tea: Steep 1-2 teaspoons of dried gentian root in boiling water for 3-10 minutes, taken 3 times a day before meals

- Liquid Extracts: 0.5-1.5 ml, 3 times a day

These dosage forms can be used to support:

- Digestive health: Stimulating digestive enzymes and improving appetite

- Appetite stimulation: Enhancing appetite in individuals with digestive issues

When choosing a dosage form, consider factors like:

- Convenience: Capsules or tablets may be more convenient than teas or tinctures

- Potency: Standardized extracts may offer more consistent potency

- Individual needs: Consult a healthcare professional to determine the best dosage form and dosage for specific needs

When should Gentian Root Extract Manufactured by MEDIOCON INC be taken?

Gentian root extract is typically taken:

- Before meals: To stimulate digestive enzymes and improve appetite

- 2-3 times a day: To maintain consistent digestive support

The exact timing may vary depending on individual needs and product instructions. Consult a healthcare professional for personalized guidance.

Some general guidelines include:

- Capsules or tablets: Take 30 minutes to 1 hour before meals

- Tincture: Take 10-20 drops in water 15-30 minutes before meals

- Tea: Drink 3 times a day, before meals

    What are the effects And Side effects of Gentian Root Extract Manufactured by MEDIOCON INC?

Gentian root extract has various effects and potential side effects:

- Benefits:

    - Digestive support: Stimulates digestive enzymes, improving digestion and appetite

    - Appetite stimulation: Enhances appetite in individuals with digestive issues

    - Antimicrobial and anti-inflammatory: Exhibits antimicrobial and anti-inflammatory properties

- Side effects:

    - Headaches: Possible side effect, especially in large doses

    - Stomach discomfort: May cause stomach upset or discomfort in some individuals

    - Interactions: May interact with certain medications, such as antihypertensive drugs

 

Precautions:

- Pregnancy and breastfeeding: Insufficient safety data; consult a healthcare professional before using gentian root extract

- Stomach ulcers or gastritis: May exacerbate conditions; consult a healthcare professional before using

- Allergic reactions: Rare, but possible; monitor for signs of allergic reactions

  How is Gentian Root Extract Manufactured by MEDIOCON  INC  Tested Qualitatively?

Gentian root extract is tested qualitatively using various methods, including:

- High-Performance Liquid Chromatography (HPLC): Identifies and quantifies bioactive compounds like secoiridoids.

- Thin-Layer Chromatography (TLC): Separates and identifies compounds based on their properties.

- Gas Chromatography-Mass Spectrometry (GC-MS): Analyzes volatile compounds and identifies specific constituents.

- Spectroscopy: Techniques like UV-Vis spectroscopy or infrared spectroscopy can help identify specific compounds.

These tests help ensure the quality, purity, and potency of gentian root extract.

   Which tests are performed on Gentian Root Extract Manufactured by  MEDIOCON INC ?

Gentian root extract undergoes various tests to ensure quality, safety, and efficacy. Some common tests include:

- Chemical analysis: HPLC, GC-MS, or TLC to identify and quantify bioactive compounds like secoiridoids.

- Microbial testing: To ensure the extract is free from harmful microorganisms like bacteria, yeast, and mold.

- Heavy metal testing: To detect presence of heavy metals like lead, mercury, and arsenic.

- Pesticide residue testing: To ensure the extract is free from pesticide residues.

- Standardization: To ensure consistent levels of active compounds.

- Stability testing: To assess shelf life and storage conditions.

- Sensory evaluation: To assess appearance, aroma, and taste.

These tests help ensure the quality and safety of gentian root extract products.

What are the challenges in Manufacturing of Stevia Extract Manufactured by MEDIOCON   INC API?

The manufacturing of Stevia Extract API faces several challenges, including¹ ² ³:

- Technological advancements and quality control measures: Implementing advanced extraction techniques like supercritical fluid extraction and ensuring quality control measures to produce high-quality stevia extracts can be challenging due to the requirement of significant investment in equipment and expertise.

- Efficient removal of impurities: Purification and crystallization processes can be challenging, especially in efficiently removing impurities without affecting the quality of stevia glycosides.

- Cost and technical know-how constraints: Widespread adoption of advanced extraction techniques is limited due to cost and technical know-how constraints.

- Supply chain disruptions: Global supply chains, including those for stevia, can be disrupted by events like the COVID-19 pandemic, affecting the availability and cost of stevia.

- Variety development and breeding: Developing stevia varieties with high yields of desired glycosides, such as Rebaudioside A, can be a challenge, but advancements in breeding and agronomy research can help address this.

- Sustainability challenges: Traditional stevia extraction processes have been associated with sustainability challenges, and there is a need to explore novel and sustainable advancements in the manufacturing process.

- Raw material sourcing and processing: Ensuring a consistent supply of high-quality stevia leaves and optimizing processing conditions to maintain the quality of the extract can be a challenge.

These challenges highlight the complexity of stevia extract manufacturing, requiring ongoing research, investment, and innovation to improve efficiency, quality, and sustainability.

What are the challenges in manufacturing of Gentian Root Extract Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Gentian Root Extract dosage forms poses several challenges, including¹ ² ³:

- Raw Material Sourcing: Ensuring a consistent supply of high-quality gentian roots, which can be affected by factors like overharvesting and environmental conditions. Gentian root is often sourced from wild collections in France, Spain, and the Balkan countries, as well as farms in France and Germany.

- Quality Control: Standardizing the extract to ensure consistent levels of active compounds like gentiopicroside and amarogentin, which contribute to the bitter taste and therapeutic effects.

- Dosage Form Development: Creating dosage forms that effectively deliver the extract, such as tablets, capsules, tinctures, or teas, while maintaining the stability and bioavailability of the active compounds.

- Stability and Bioavailability: Ensuring the extract's stability and bioavailability in various dosage forms, as gentiopicroside has a short elimination half-life and low bioavailability.

- Regulatory Compliance: Meeting regulatory requirements, such as those specified in the European Pharmacopoeia, to ensure the quality and safety of gentian root extract products.

- Potential Interactions: Considering potential interactions with other medications, such as antihypertensive drugs, and contraindications, like gastric ulcers or pregnancy.

- Dosage and Administration: Determining the optimal dosage and administration schedule, as excessive doses can cause adverse reactions like nausea, headaches, or stomach discomfort.

To overcome these challenges, manufacturers may employ advanced technologies, such as gastroretentive floating granules or mucoadhesive-floating systems, to enhance the bioavailability and efficacy of gentian root extract dosage forms.

What is the Packing for Gentian Root Extract Manufactured by MEDIOCON INC?

Gentian root extract packing options vary depending on the supplier and product specifications. Here are some common packing options:

- Drums: HDPE drums with capacities ranging from 1 kg to 50 kg or 25 kg

- Pouches/Bags: Polybags, packets, or bags with capacities ranging from 1 kg to 25 kg

- Cartons: 10 kg or 25 kg cartons

- Boxes: Customized box packaging with capacities like 25 kg

Some suppliers also offer¹ ²:

- Paper drums with plastic bags: 25 kg/drum, often used for bulk shipments

- Pallets: 40 drums per pallet for large-scale deliveries

Packing details may differ based on the manufacturer, product form (powder, liquid, or capsule), and customer requirements. Always confirm packing specifications with the supplier.

 What is shelf life Of Gentian Root Extract Manufactured by MEDIOCON INC? 

Gentian root extract typically has a shelf life of 2 years, provided it's stored properly in a cool, dry place. However, the shelf life may vary depending on the specific product formulation and storage conditions.

Some key factors that can affect shelf life include:

- Storage conditions: Keeping the extract away from direct sunlight, moisture, and heat can help maintain its potency.

- Packaging: The type of packaging used, such as airtight containers or drums, can also impact shelf life.

- Product formulation: Different formulations, like powder or liquid extracts, may have varying shelf lives.

Here are some general guidelines for gentian root extract shelf life based on product types¹ ² ³:

- Powdered extract: 2 years

- Liquid extract: 1, depending on the formulation and preservative used

- Gentiana lutea root extract: 12 months, as seen in some cosmetic applications

Keep in mind that these are general estimates, and the actual shelf life may vary depending on the specific product and manufacturer. Always check the product label or consult with the supplier for specific storage and shelf life recommendations.

What should the label claim for Gentian Root Extract Manufactured by MEDIOCON INC   Include?

The label claim for Gentian Root Extract should include:

- Botanical name: Gentiana lutea

- Part of plant used: Root

- Active compounds: Gentiopicroside, amarogentin, or other relevant compounds

- Concentration: Percentage or amount of active compounds (e.g., 10% gentiopicroside)

- Recommended dosage: Specific dosage instructions

- Storage conditions: Instructions for proper storage (e.g., cool, dry place)

- Shelf life: Expiration date or shelf life

- Cautionary statements: Warnings for potential interactions or contraindications (e.g., pregnancy, breastfeeding, or certain medical conditions)

- Manufacturer information: Name and contact details of the manufacturer or supplier

 

Additionally, labels may claim benefits like:

- Digestive support

- Appetite stimulation

- Bitter digestive

- Traditional herbal use

Where can Gentian Root Extract Manufactured by MEDIOCON INC are procured?

Gentian Root Extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Gentian Root Extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Gentian Root Extract Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Gentian Root Extract Manufactured by MEDIOCON INC product, regardless of the procurement source.