Smoke Tree Extract 528-48-3 Manufactured by MEDIOCON INC

 

 

Smoke Tree Extract Manufactured by MEDIOCON INC     

 

   Name: Smoke Tree Extract

 

   CAS No:  528-48-3

 

Molecular Weight:  286.24g/mol

Molecular formula:   C₁₅H₁₀O₆

Synonyms:  Cotinus coggygria extract, Cotinus obovatus extract (American smoketree), and sometimes more generally Rhuz cotinus extract

Appearance:  a yellow to brown fine powder.

 Solubility :  Soluble in Ethanol, Methanol.

Use :

Smoke Tree Extract, derived from the Cotinus coggygria plant, has various uses:

- Skincare: Antioxidant and anti-inflammatory properties may help soothe skin irritations and protect against environmental stressors.

- Traditional medicine: Used in some traditional practices to treat digestive issues, fever, and inflammation.

- Dye: The plant's leaves and stems can be used as a natural dye.

- Ornamental purposes: Smoke trees are cultivated for their attractive foliage and unique flower plumes.

 

Some potential benefits of Smoke Tree Extract include:

- Antioxidant activity: May help protect against oxidative stress and cell damage.

- Anti-inflammatory effects: May help reduce inflammation and alleviate symptoms associated with conditions like arthritis.

- Antimicrobial properties: May exhibit antimicrobial activity against certain bacteria or fungi.

 How is  Smoke Tree Extract manufactured by MEDIOCON INC Synthesized?

Smoke Tree Extract is typically synthesized through various extraction methods, including:

- Solvent extraction: Using solvents like ethanol, methanol, or acetone to extract bioactive compounds from the plant material.

- Water extraction: Using water as a solvent to extract water-soluble compounds.

- Supercritical fluid extraction: Using supercritical fluids, like CO2, to extract compounds without solvents.

- Cold pressing: Mechanical extraction of oils from the plant material.

 

The extraction process may involve:

- Grinding or milling: Reducing the plant material to a fine powder.

- Extraction: Applying the chosen extraction method.

- Filtration: Removing impurities and solids.

- Concentration: Concentrating the extract through evaporation or other methods.

- Purification: Further purifying the extract using techniques like chromatography.

What are the different  dosage forms  of   Smoke Tree Extract Manufactured  by  MEDIOCON INC?

Smoke Tree Extract is available in various dosage forms, including¹ ² ³:

- Powder: A light brown to yellow fine powder with a particle size of 80-100 mesh, often standardized to contain 10-98% fisetin.

- Capsules: Containing 50-150mg of fisetin per serving, suitable for dietary supplements.

- Tablets: Formulated with fisetin and other ingredients, providing a convenient dosage form.

- Topical formulations: Creams, serums, and masks for skincare, leveraging its antioxidant and anti-inflammatory properties.

- Hair care products: Shampoos, conditioners, and hair masks to promote hair health and reduce dandruff.

- Teas and tinctures: Liquid extracts used for their potential health benefits, including antioxidant and anti-inflammatory effects.

 

When choosing a Smoke Tree Extract product, consider factors like:

- Fisetin content: Look for products standardized to contain a specific percentage of fisetin.

- Manufacturer reputation: Ensure the product is from a reputable manufacturer that follows good manufacturing practices (GMPs).

- Label claims: Check the label for clear instructions on usage and dosage.

- Certifications: Consider products with certifications like ISO 22000, HALAL, or KOSHER for quality assurance.

 How Smoke Tree Extract Manufactured by MEDIOCON INC   Dosage Forms are prepared?

The preparation of Smoke Tree Extract dosage forms involves several steps:

Powder Preparation

1. Grinding: Smoke tree plant material is ground into a fine powder.

2. Extraction: The powder is extracted using solvents like ethanol or water.

3. Filtration: The extract is filtered to remove impurities.

4. Concentration: The extract is concentrated through evaporation or other methods.

5. Drying: The concentrated extract is dried to obtain a powder.

Capsule Preparation

1. Powder filling: The Smoke Tree Extract powder is filled into capsules.

2. Excipient addition: Excipients like fillers, binders, or lubricants may be added.

3. Capsule sealing: The capsules are sealed to prevent leakage.

Tablet Preparation

1. Powder blending: The Smoke Tree Extract powder is blended with excipients.

2. Granulation: The powder blend is granulated to improve flowability.

3. Tabletting: The granules are compressed into tablets.

Topical Formulation Preparation

1. Emulsification: The Smoke Tree Extract is mixed with oils and emulsifiers.

2. Cream or serum formulation: The extract is formulated into creams, serums, or masks.

Quality Control

1. Standardization: Ensuring consistent levels of active compounds like fisetin.

2. Testing: Conducting tests for purity, potency, and stability.

What are the appropriate Dosage forms of Smoke Tree Extract Manufactured  by  MEDIOCON   INC?                

The appropriate dosage forms of Smoke Tree Extract depend on the intended use:

For Health Supplements

1. Capsules: Convenient for oral consumption, often containing 50-150mg of fisetin per serving.

2. Tablets: Formulated with fisetin and other ingredients, providing a convenient dosage form.

For Skincare

1. Topical creams: Formulated to deliver antioxidant and anti-inflammatory benefits to the skin.

2. Serums: Concentrated formulations for targeted skin benefits.

3. Masks: Sheet masks or cream masks infused with Smoke Tree Extract.

For Hair Care

1. Shampoos: Formulated to promote hair health and reduce dandruff.

2. Conditioners: Moisturizing and nourishing hair care products.

Other Forms

1. Powders: Can be used in food, beverages, or as a dietary supplement ingredient.

2. Teas or tinctures: Liquid extracts for oral consumption.

 

When choosing a dosage form, consider factors like:

- Intended use: Skincare, hair care, or health supplements.

- Active compound levels: Ensure the product contains sufficient fisetin.

- Manufacturer reputation: Choose products from reputable manufacturers.

 

Always follow the recommended dosage and consult with a healthcare professional if necessary.

When should Smoke Tree Extract Manufactured by MEDIOCON INC be taken?

The timing of taking Smoke Tree Extract depends on the intended use and individual needs. Here are some general guidelines:

For General Health and Wellness

1. With meals: Taking Smoke Tree Extract with meals may enhance absorption and reduce potential stomach upset.

2. Consistency: Take it at the same time every day to maintain consistent levels of fisetin in the body.

For Skincare and Anti-Aging Benefits

1. Topical application: Apply Smoke Tree Extract topically to the skin as part of a skincare routine, ideally in the morning and/or evening.

For Hair Care

1. As part of hair care routine: Use Smoke Tree Extract-infused shampoos, conditioners, or hair masks as part of regular hair care.

Considerations

1. Consult a healthcare professional: Before taking Smoke Tree Extract, especially if you have underlying health conditions or take medications.

2. Follow recommended dosages: Adhere to the recommended dosage on the product label or consult with a healthcare professional.

3. Monitor effects: Pay attention to how your body responds to Smoke Tree Extract and adjust usage accordingly.

 What are the effects And Side effects of Smoke Tree Extract Manufactured by MEDIOCON INC?

Smoke Tree Extract has various effects and potential side effects:

Potential Benefits:

- Antioxidant and Anti-Inflammatory Effects: Smoke Tree Extract has high phenolic content and antioxidant properties, which may help protect against oxidative stress and inflammation.

- Antimicrobial Properties: The extract has been shown to exhibit antimicrobial activity, making it potentially useful for treating infections and promoting wound healing.

- Digestive Health: Smoke Tree Extract may help treat diarrhea, colitis, and gastric ulcers due to its astringent and anti-inflammatory properties.

- Skincare and Wound Healing: The extract's antimicrobial and anti-inflammatory properties may aid in treating acne, wounds, and skin conditions like eczema.

Potential Side Effects:

- Allergic Reactions: Some individuals may experience skin irritation or allergic reactions when using Smoke Tree Extract.

- Dermatitis: Skin contact with the plant can cause dermatitis in sensitive individuals.

- Interactions with Medications: Smoke Tree Extract may interact with certain medications, such as anticoagulants, and affect their efficacy or increase the risk of side effects.¹ ²

Precautions:

- Pregnancy and Breastfeeding: There is limited research on the safety of Smoke Tree Extract during pregnancy and breastfeeding. Consult a healthcare professional before using it.

- Surgery: Stop using Smoke Tree Extract at least two weeks before scheduled surgery due to its potential anticoagulant effects.³

It's essential to consult with a healthcare professional before using Smoke Tree Extract, especially if you have underlying health conditions or are taking medications.

  How is Smoke Tree Extract Manufactured by MEDIOCON  INC  Tested Qualitatively?

Smoke Tree Extract manufacturing involves qualitative testing to ensure quality and purity. Here's an overview:

Raw Material Selection

1. Quality control: Selecting high-quality Smoke Tree plant material.

2. Identification: Verifying the plant species and part used (e.g., leaves, roots).

Extraction Process

1. Solvent selection: Choosing suitable solvents (e.g., ethanol, water).

2. Extraction method: Employing methods like maceration, percolation, or supercritical fluid extraction.

Qualitative Testing

1. Phytochemical screening: Identifying presence of bioactive compounds (e.g., flavonoids, phenolic acids).

2. High-performance liquid chromatography (HPLC): Analyzing and quantifying specific compounds (e.g., fisetin).

3. Gas chromatography-mass spectrometry (GC-MS): Identifying volatile compounds.

Quality Control Measures

1. Purity testing: Ensuring absence of contaminants (e.g., heavy metals, pesticides).

2. Potency testing: Verifying the extract's bioactive compound content.

3. Stability testing: Assessing the extract's shelf life and stability.

Certification and Compliance

1. Good Manufacturing Practices (GMP): Following GMP guidelines to ensure quality and safety.

2. Regulatory compliance: Meeting regulatory requirements (e.g., FDA, EU) for food supplements or cosmetics.

By incorporating these qualitative testing measures, manufacturers can ensure the quality and efficacy of Smoke Tree Extract products.

   Which tests are performed on Smoke Tree Extract Manufactured by  MEDIOCON INC ?

Smoke Tree Extract undergoes various tests to ensure its quality and purity. These tests include¹:

- Physical Characteristics Tests:

    - Particle Size: Ensuring the powder passes through an 80-mesh sieve with ≥95% efficiency (tested using GB/T5507-2008 method).

    - Loss on Drying: Verifying moisture content is ≤2% (tested using GB5009.3 method).

    - Bulk Density: Measuring the density, which should be between 40-60 g/100ml (tested using CP2015 method).

- Chemical Characteristics Tests:

    - Residual Solvent: Ensuring the extract meets European Pharmacopoeia (EP4) standards.

    - Pesticide Residue: Verifying compliance with EP4 standards.

    - Heavy Metals: Testing for heavy metals like lead (≤2 ppm), arsenic (≤2 ppm), cadmium (≤0.5 ppm), and mercury (≤0.5 ppm) using methods like USP<231> and GB5009.11-17.

- Microbiological Tests:

    - Total Plate Count: Ensuring ≤1000 cfu/g (tested using GB4789.2 method).

    - Total Yeast & Mold: Verifying ≤100 cfu/g (tested using GB4789.15 method).

    - Pathogen Testing: Ensuring absence of pathogens like E. coli, Salmonella, and Staphylococcus using methods like GB4789.3-4 and CP2015.

- High-Performance Liquid Chromatography (HPLC): Analyzing the extract's purity and potency, particularly for fisetin content.

- Gas Chromatography-Mass Spectrometry (GC-MS): Detecting contaminants or impurities in the extract.

These tests help ensure the Smoke Tree Extract meets quality standards for use in various applications, including food supplements and cosmetics.

What are the challenges in Manufacturing of Smoke Tree Extract Manufactured by MEDIOCON   INC API?

Manufacturing Smoke Tree Extract API poses several challenges, including¹ ² ³:

- Regulatory Compliance: Ensuring adherence to Good Manufacturing Practices (GMP) and regulatory guidelines, such as Schedule M (Revised) in India, is crucial. This includes maintaining detailed records, validating processes, and conducting regular audits.

- Quality Control: Implementing robust quality control systems to ensure the extract meets purity and potency standards is vital. This involves testing raw materials, intermediate batches, and final products.

- Raw Material Sourcing: Sourcing high-quality raw materials consistently can be challenging. Establishing approved vendor lists and testing raw materials for identity, potency, and impurities are essential.

- Scalability: Scaling up production while maintaining consistency and quality can be difficult. Close monitoring of each step is necessary to prevent unexpected outcomes, such as new impurities or increased impurity levels.

- Infrastructure and Equipment: Upgrading facilities and equipment to meet environmental and safety requirements can be expensive. Regular calibration and maintenance of equipment are necessary to prevent contamination.

- Employee Training: Providing comprehensive training programs for employees on GMP practices, safety protocols, and equipment handling is critical to maintaining high standards of production and compliance.

- Supply Chain Complexities: Managing external partnerships, ensuring timely deliveries, and maintaining strong relationships with suppliers and contractors are essential for smooth operations.

- Cultural and Communication Differences: In cases of technology transfers or collaborations, cultural and communication differences can pose significant challenges. Careful planning, frequent communication, and cultural training can help overcome these issues.

- Process Validation: Validating critical steps in the manufacturing process, such as reaction, filtration, and drying, is necessary to ensure consistency and quality.

- Environmental, Health, and Safety (EHS) Compliance: Implementing proper training for employees in safety protocols, providing personal protective equipment, and having emergency response plans in place are crucial for EHS compliance.

 

By understanding and addressing these challenges, manufacturers can ensure the production of high-quality Smoke Tree Extract API that meets regulatory standards and customer expectations.

What are the challenges in manufacturing of Smoke Tree Extract Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Smoke Tree Extract dosage forms poses several challenges, including:

 

Physical Challenges

 

- Stability Issues: Smoke Tree Extract is susceptible to chemical and physical changes over time, leading to degradation, alteration of potency, and contamination.

- Particle Aggregation: Solid particles in liquid formulations can aggregate, causing sedimentation, inconsistent dosing, and potential blockages.

- Foaming: Agitation and shear forces can lead to foam formation, affecting product stability and dosing accuracy.

 

Chemical Challenges

 

- Poor Solubility: Some compounds in Smoke Tree Extract may be difficult to solubilize, leading to precipitation and sedimentation.

- Interactions: Active ingredients or excipients can interact with each other or container materials, affecting product stability and efficacy.

Manufacturing Challenges

- Microbial Contamination: Liquid dosage forms are susceptible to microbial contamination, which can lead to product recall and safety concerns.

- Container Closure Integrity: Inadequate closure systems can allow oxygen or moisture to enter, causing product degradation or contamination.

- Process Validation: Ensuring consistency and quality in the manufacturing process can be challenging, particularly for new dosage forms.

Regulatory Challenges

- Compliance: Meeting regulatory requirements, such as Good Manufacturing Practices (GMP), is crucial to ensure product quality and safety.

- Standardization: Ensuring consistency in the extract's bioactive compound content, such as fisetin, is essential for quality control.

What is the Packing for Smoke Tree Extract Manufactured by MEDIOCON INC?

Smoke Tree Extract packing varies depending on the manufacturer and intended use. Here are some common packaging options¹ ² ³:

- Drum packaging: 25kg drums are commonly used for bulk quantities.

- Foil bag packaging: 1kg foil bags are suitable for smaller quantities.

- Paper drums with plastic bags: Some manufacturers pack Smoke Tree Extract in paper drums with plastic bags inside.

- Custom packaging: Depending on the customer's requirements, Smoke Tree Extract can be packaged in various sizes, such as 200gm or 300gm packs.

The packaging material and size may differ based on the specific product and manufacturer. It's essential to check with the supplier for their specific packaging options and details.

What is shelf life Of Smoke Tree Extract Manufactured by MEDIOCON INC? 

Smoke Tree Extract, rich in fisetin, typically has a shelf life of 2 years when stored properly. To maintain its potency and quality, it's essential to store it in a cool, dry place, away from direct sunlight and heat.

Storage Recommendations:

- Temperature: Below 25°C (77°F)

- Humidity: Keep it dry

- Light Protection: Store in opaque containers or away from direct sunlight

- Container: Tightly sealed containers to prevent moisture and air exposure

Proper storage ensures the extract remains stable and effective for its intended use. Always check the product label or manufacturer's guidelines for specific storage instructions

What should the label claim for Smoke Tree Extract Manufactured by MEDIOCON INC   Include?

The label claim for Smoke Tree Extract should include the following information:

- Product Name: Smoke Tree Extract or specific product name

- Active Ingredient: Fisetin content (e.g., "Standardized to contain 10% Fisetin")

- Net Weight: Quantity of extract in the package

- Recommended Use: Intended use (e.g., dietary supplement, skincare)

- Recommended Dosage: Suggested dosage or usage instructions

- Storage Instructions: Guidelines for storing the extract (e.g., cool, dry place)

- Caution/ Warning: Any relevant warnings or cautions (e.g., "Consult a healthcare professional before use")

- Manufacturer Information: Name and contact details of the manufacturer or distributor

- Batch Number: Batch or lot number for quality control and tracking

- Expiry Date: Shelf life or expiration date

The label claim should be accurate, clear, and compliant with regulatory requirements. It's essential to ensure the label information is consistent with the product's specifications and intended use.

Where can Smoke Tree Extract Manufactured by MEDIOCON INC are procured?

Smoke Tree Extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Smoke Tree Extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Smoke Tree Extract Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Smoke Tree Extract Manufactured by MEDIOCON INC product, regardless of the procurement source.