White Willow Bark Extract 84082-82-6 Manufacturer Exporter MEDIOCON INC

 

 

White Willow Bark Extract Manufactured by MEDIOCON INC     

 

   Name: White Willow Bark Extract

 

   CAS No:  84082-82-6

 

Molecular Weight: 286.28 g/mol

  Molecular formula:   C₁₃H₁₈O₇

Synonyms:  Salix Alba

Appearance:  light brown to white powder.

 

   Solubility :  soluble in water but insoluble in alcohol (like ethanol) and ether.

    Use :

White Willow Bark Extract is known for its various uses, including:

 

1. Pain relief: It contains salicin, a compound similar to aspirin, which helps alleviate headaches, arthritis, and muscle pain.

2. Anti-inflammatory: Its anti-inflammatory properties make it useful for reducing swelling and pain.

3. Skincare: It's used in skincare products for its anti-inflammatory and antioxidant properties, which can help soothe and protect the skin.

 How is  White Willow Bark Extract manufactured by MEDIOCON INC Synthesized?

MEDIOCON INC doesn't seem to have publicly available information on their specific manufacturing process for White Willow Bark Extract. However, I can walk you through the general process used by most manufacturers.

 

Manufacturing Process

- Raw Material Selection: White willow bark is carefully sourced from healthy trees, typically grown in suitable environments with proper sunlight exposure and soil conditions.

- Washing: The bark is washed to remove contaminants like dirt, dust, and other debris that may have adhered during collection or storage.

- Extraction: Techniques like maceration or percolation are used to extract bioactive substances from the bark. Solvents such as ethanol or water-ethanol mixtures are often employed.

- Filtration: The extract is filtered to remove solid residues, resulting in a clear and pure extract.

- Refining: Purification techniques like distillation or chromatography are applied to isolate specific bioactive substances, enhancing the extract's potency and purity.

- Quality Assurance: The final product undergoes rigorous testing for chemical composition, microbial content, and stability to ensure it meets quality and safety standards.

What are the different  dosage forms  of   White Willow Bark Extract Manufactured  by  MEDIOCON INC?

White Willow Bark Extract comes in various dosage forms, including:

 

1. Capsules: Convenient oral form with standardized extracts.

2. Tea: Herbal tea made by steeping dried willow bark.

3. Tinctures: Liquid extracts, often in alcohol or glycerin.

4. Powders: Can be mixed into smoothies or capsules.

5. Topical creams/ointments: For localized pain relief and skin issues.

6. Lozenges: Oral form for soothing throat or mouth issues.

7. Liquid extracts: Concentrated liquid forms for oral use.

 

These various forms offer flexibility in using White Willow Bark Extract for different purposes.

  How White Willow Bark Extract Manufactured by MEDIOCON INC   Dosage Forms are prepared?

The preparation of White Willow Bark Extract dosage forms varies depending on the form. Here's a general overview:

 

Capsules

1. Extraction: Willow bark is extracted using solvents like ethanol or water.

2. Concentration: The extract is concentrated to a specific strength (e.g., standardized to salicin content).

3. Filling: The concentrated extract is filled into capsules, often with excipients like fillers or binders.

4. Quality control: Final product testing for purity, potency, and contaminants.

 

Tea

1. Drying: Willow bark is dried to remove excess moisture.

2. Cutting: The dried bark is cut into smaller pieces or powdered.

3. Steeping: The dried bark is steeped in hot water to release active compounds.

4. Strain: The liquid is strained, and the tea is ready for consumption.

 

Tinctures

1. Extraction: Willow bark is extracted using a solvent like ethanol or glycerin.

2. Concentration: The extract is concentrated to a specific strength.

3. Filtering: The extract is filtered to remove impurities.

4. Bottling: The final product is bottled and ready for use.

 

Powders

1. Extraction: Willow bark is extracted using solvents or mechanical methods.

2. Drying: The extract is dried to a powder form.

3. Milling: The powder is milled to a uniform particle size.

4. Packaging: The powder is packaged in airtight containers.

 

Topical creams/ointments

1. Extraction: Willow bark is extracted using solvents or mechanical methods.

2. Blending: The extract is blended with other ingredients like oils, emulsifiers, and preservatives.

3. Formulation: The blend is formulated into a cream or ointment.

4. Quality control: Final product testing for stability, efficacy, and safety.

These general steps may vary depending on the manufacturer and specific product requirements.

What are the appropriate Dosage forms of White Willow Bark Extract Manufactured  by  MEDIOCON   INC?                

The appropriate dosage forms of White Willow Bark Extract depend on the intended use and individual preferences. Here are some common forms:

 

For Pain Relief and Anti-Inflammation

1. Capsules: Standardized extracts in capsule form, often containing 120-240 mg of salicin.

2. Tablets: Similar to capsules, but in tablet form.

3. Liquid Extracts: Concentrated liquid forms, often taken sublingually or added to water.

 

For Topical Use

1. Creams: Topical creams for localized pain relief and skin issues.

2. Ointments: Topical ointments for pain relief and skin protection.

3. Gels: Lightweight, easily absorbed gels for topical application.

 

For General Wellness

1. Tea: Herbal tea made by steeping dried willow bark.

2. Powders: Can be mixed into smoothies or taken as a supplement.

 

Other Forms

1. Tinctures: Liquid extracts, often used sublingually or added to water.

2. Lozenges: Oral form for soothing throat or mouth issues.

 

When choosing a dosage form, consider factors like:

 

- Intended use (pain relief, skin issues, general wellness)

- Individual preferences (e.g., capsules, tea, topical creams)

- Product standardization (ensure consistent salicin content)

- Manufacturer reputation and quality control

When should White Willow Bark Extract Manufactured by MEDIOCON INC be taken?

The timing of taking White Willow Bark Extract depends on the intended use and individual needs. Here are some general guidelines:

 

For Pain Relief

1. As needed: Take White Willow Bark Extract when experiencing pain or discomfort, such as headaches, arthritis, or menstrual cramps.

2. With food: Taking it with food may help reduce stomach upset or digestive issues.

 

For Chronic Conditions

1. Regularly: Take White Willow Bark Extract at the same time each day, as directed by the manufacturer or healthcare provider, to maintain consistent levels of salicin in the body.

2. Long-term use: Consult with a healthcare provider for prolonged use, especially if you're taking other medications or have underlying health conditions.

 

For General Wellness

1. Morning or evening: Take White Willow Bark Extract at a time that works best for your schedule, such as with breakfast or before bed.

 

Precautions

1. Consult a healthcare provider: Before taking White Willow Bark Extract, especially if you're pregnant, breastfeeding, or taking medications.

2. Follow dosage instructions: Adhere to the recommended dosage and consult with a healthcare provider if you have concerns.

 

Some popular White Willow Bark Extract products include:

1. Nature’s Answer Willow Bark Extract: 1000mg herb equivalent per 1ml.

2. Bulk White Willow Bark Powder: Standardized to 15% salicin.

 

When taking White Willow Bark Extract, monitor your body's response and adjust your dosage or timing as needed. If you experience any adverse effects, discontinue use and consult with a healthcare provider.

 What are the effects And Side effects of White Willow Bark Extract Manufactured by MEDIOCON INC?

Effects of White Willow Bark Extract

1. Pain relief: Reduces inflammation and alleviates pain, including headaches, arthritis, and menstrual cramps.

2. Anti-inflammatory: Helps reduce swelling and inflammation.

3. Antioxidant: Protects against oxidative stress and cell damage.

4. Antipyretic: May help reduce fever.

 

Side Effects of White Willow Bark Extract

1. Stomach upset: Nausea, vomiting, and stomach pain, especially when taken in large doses.

2. Allergic reactions: Rarely, some individuals may experience allergic reactions, such as hives or itching.

3. Bleeding risk: May increase the risk of bleeding, especially when taken with anticoagulant medications.

4. Interactions: May interact with certain medications, such as blood thinners, diabetes medications, and blood pressure medications.

 

Precautions

1. Pregnancy and breastfeeding: Consult with a healthcare provider before using White Willow Bark Extract during pregnancy or breastfeeding.

2. Bleeding disorders: Use with caution if you have bleeding disorders or take anticoagulant medications.

3. Surgery: Stop taking White Willow Bark Extract 2 weeks before surgery to minimize bleeding risks.

 

Interactions

1. Blood thinners: May increase the risk of bleeding when taken with anticoagulant medications.

2. Diabetes medications: May interact with diabetes medications, affecting blood sugar levels.

3. Blood pressure medications: May interact with blood pressure medications, affecting blood pressure levels.

 

It's essential to consult with a healthcare provider before taking White Willow Bark Extract, especially if you have underlying health conditions or take medications.

  How is White Willow Bark Extract Manufactured by MEDIOCON  INC  Tested Qualitatively?

Qualitative testing of White Willow Bark Extract involves various methods to ensure its quality, purity, and potency. Here are some common tests:

Physical Tests

1. Appearance: Visual inspection for color, texture, and consistency.

2. Solubility: Testing for solubility in various solvents.

Chemical Tests

1. High-Performance Liquid Chromatography (HPLC): Analyzes salicin content and other bioactive compounds.

2. Gas Chromatography (GC): Identifies volatile compounds.

3. Spectroscopy: Techniques like UV-Vis or IR spectroscopy to analyze chemical composition.

Microbiological Tests

1. Microbial contamination: Testing for presence of microorganisms like bacteria, yeast, or mold.

2. Sterility testing: Ensures the product is free from microbial contaminants.

Other Tests

1. Heavy metal analysis: Testing for presence of heavy metals like lead, mercury, or arsenic.

2. Pesticide residue analysis: Testing for presence of pesticide residues.

Quality Control Parameters

1. Salicin content: Ensures the extract meets the labeled salicin content.

2. Purity: Verifies the absence of adulterants or contaminants.

3. Potency: Ensures the extract's bioactive compounds are present in sufficient quantities.

 

These tests help ensure the quality and safety of White Willow Bark Extract, providing consumers with a reliable product.

   Which tests are performed on White Willow Bark Extract Manufactured by  MEDIOCON INC ?

Qualitative testing of White Willow Bark Extract involves various methods to ensure its quality, purity, and potency. Here are some common tests:

Physical Tests

1. Appearance: Visual inspection for color, texture, and consistency.

2. Solubility: Testing for solubility in various solvents.

Chemical Tests

1. High-Performance Liquid Chromatography (HPLC): Analyzes salicin content and other bioactive compounds.

2. Gas Chromatography (GC): Identifies volatile compounds.

3. Spectroscopy: Techniques like UV-Vis or IR spectroscopy to analyze chemical composition.

Microbiological Tests

1. Microbial contamination: Testing for presence of microorganisms like bacteria, yeast, or mold.

2. Sterility testing: Ensures the product is free from microbial contaminants.

Other Tests

1. Heavy metal analysis: Testing for presence of heavy metals like lead, mercury, or arsenic.

2. Pesticide residue analysis: Testing for presence of pesticide residues.

Quality Control Parameters

1. Salicin content: Ensures the extract meets the labeled salicin content.

2. Purity: Verifies the absence of adulterants or contaminants.

3. Potency: Ensures the extract's bioactive compounds are present in sufficient quantities.

 

These tests help ensure the quality and safety of White Willow Bark Extract, providing consumers with a reliable product.

What are the challenges in Manufacturing of White Willow Bark Extract Manufactured by MEDIOCON   INC API?

The manufacturing of White Willow Bark Extract API (Active Pharmaceutical Ingredient) faces several challenges:

Raw Material Challenges

1. Quality variation: Variability in salicin content and other bioactive compounds due to factors like climate, soil, and harvesting practices.

2. Sourcing: Ensuring sustainable and responsible sourcing of willow bark.

Extraction and Purification Challenges

1. Extraction efficiency: Optimizing extraction methods to maximize salicin yield while minimizing impurities.

2. Purification: Removing impurities and achieving high purity levels.

Regulatory Challenges

1. Standardization: Ensuring consistent salicin content and quality across batches.

2. Compliance: Meeting regulatory requirements for API manufacturing, such as GMP (Good Manufacturing Practices).

Manufacturing Challenges

1. Scalability: Scaling up production while maintaining quality and consistency.

2. Batch-to-batch variability: Minimizing variations in quality and potency between batches.

Quality Control Challenges

1. Analytical methods: Developing and validating analytical methods to ensure accurate testing of salicin content and other quality parameters.

2. Stability testing: Ensuring the stability of the API over time.

 

Addressing these challenges is crucial to ensure the quality, safety, and efficacy of White Willow Bark Extract API.

What are the challenges in manufacturing of White Willow Bark Extract Manufactured by MEDIOCON  INC ’s Dosage forms?

The manufacturing of White Willow Bark Extract dosage forms faces several challenges:

Formulation Challenges

1. Standardization: Ensuring consistent salicin content and quality across batches.

2. Excipient compatibility: Selecting excipients that are compatible with the extract and do not affect its stability or bioavailability.

Manufacturing Challenges

1. Process optimization: Optimizing manufacturing processes to ensure consistent quality and potency.

2. Scalability: Scaling up production while maintaining quality and consistency.

Quality Control Challenges

1. Analytical methods: Developing and validating analytical methods to ensure accurate testing of salicin content and other quality parameters.

2. Stability testing: Ensuring the stability of the dosage form over time.

Regulatory Challenges

1. Compliance: Meeting regulatory requirements for dosage form manufacturing, such as GMP (Good Manufacturing Practices).

2. Labeling and claims: Ensuring labeling and claims comply with regulatory requirements.

Stability and Bioavailability Challenges

1. Stability: Ensuring the extract's stability in the dosage form.

2. Bioavailability: Ensuring the extract's bioavailability and efficacy in the dosage form.

Other Challenges

1. Raw material variability: Managing variability in raw material quality.

2. Contamination risk: Minimizing risk of contamination during manufacturing.

Addressing these challenges is crucial to ensure the quality, safety, and efficacy of White Willow Bark Extract dosage forms.

What is the Packing for White Willow Bark Extract Manufactured by MEDIOCON INC?

The packaging for White Willow Bark Extract can vary depending on the product form and intended use. Here are some common packaging options:

Packaging Options

1. Bottles: Glass or plastic bottles with tight-fitting lids to protect the extract from light, moisture, and contamination.

2. Capsules: Vegetarian capsules or gelatin capsules containing the extract, often in a bottle or blister pack.

3. Pouches: Stand-up pouches or zip-lock bags for powdered or granular extracts.

4. Tins: Metal or plastic tins for topical creams or ointments.

Packaging Considerations

1. Light protection: Packaging that protects the extract from light to prevent degradation.

2. Moisture control: Packaging that controls moisture levels to prevent degradation or clumping.

3. Tamper-evidence: Packaging that provides tamper-evident features to ensure product integrity.

4. Labeling: Clear labeling with product information, instructions, and warnings.

 

The packaging should ensure the quality, safety, and efficacy of the White Willow Bark Extract product.

What is shelf life Of White Willow Bark Extract Manufactured by MEDIOCON INC? 

The shelf life of White Willow Bark Extract can vary depending on several factors, including:

 

Factors Affecting Shelf Life

1. Storage conditions: Temperature, humidity, and light exposure can impact shelf life.

2. Packaging: Airtight containers, glass or plastic bottles, or pouches can affect shelf life.

3. Product form: Liquid, powder, or capsule forms may have different shelf lives.

 

Typical Shelf Life

1. Dried extract: 2-3 years when stored in a cool, dry place.

2. Liquid extract: 1-2 years when stored in a cool, dark place.

3. Capsules: 2-3 years when stored in a cool, dry place.

 

Storage Recommendations

1. Cool, dry place: Store away from direct sunlight and moisture.

2. Airtight containers: Use airtight containers to prevent contamination and exposure to air.

3. Follow manufacturer instructions: Check the product label for specific storage instructions and shelf life.

 

It's essential to check the product label or consult with the manufacturer for specific shelf life information.

What should the label claim for White Willow Bark Extract Manufactured by MEDIOCON INC   Include?

The label claim for White Willow Bark Extract should include the following information:

Essential Information

1. Product name: White Willow Bark Extract or similar descriptive name.

2. Active ingredient: Salicin or other relevant bioactive compounds.

3. Standardization: Statement of standardization, e.g., "Standardized to contain 15% salicin."

4. Dosage instructions: Recommended dosage and usage guidelines.

5. Warning statements: Any relevant warnings, precautions, or contraindications.

Additional Information

1. Net weight or volume: Quantity of product in the container.

2. Batch number: Unique batch or lot number for traceability.

3. Expiration date: Date after which the product should not be used.

4. Storage instructions: Recommendations for storing the product.

5. Manufacturer information: Name and contact information of the manufacturer or distributor.

 

Regulatory Compliance

1. Compliance with regulations: Ensure labeling complies with relevant regulatory requirements, such as those set by the FDA or other national regulatory agencies.

2. Truthful and not misleading: Label claims should be truthful and not misleading to consumers.

 

The label should provide clear and accurate information to help consumers use the product safely and effectively.

Where can White Willow Bark Extract Manufactured by MEDIOCON INC are procured?

White willow bark Extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find White willow bark Extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for White willow bark Extract Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the White willow bark Extract Manufactured by MEDIOCON INC product, regardless of the procurement source.