Combretum Extract 84776-30-7 Manufacturer Exporter MEDIOCON INC

 

 

Combretum Extract Manufactured by MEDIOCON INC     

 

   Name: Combretum Extract

 

   CAS No:  84776-30-7.

Molecular Weight:  NA

Molecular formula:   NA

Synonyms:  Rangoon Creeper Extract

Appearance:  a range of colors, typically light yellow to green to brown, and may be clear or slightly turbid depending on the species and extraction process.

 Solubility :  water, methanol, ethanol, acetone, and hexane extracts being common.

Use :

Combretum extract has various potential uses:

Traditional Medicine

1. Antimicrobial properties: Used to treat infections and wounds.

2. Anti-inflammatory properties: May help reduce inflammation and pain.

Health Benefits

1. Antioxidant activity: May help protect against oxidative stress.

2. Cardiovascular health: Potential benefits for heart health.

Research and Development

1. Phytochemical studies: Investigating bioactive compounds.

2. Pharmacological research: Exploring potential therapeutic applications.

 

Combretum extract's uses may vary depending on the specific species, extraction method, and preparation. Further research is needed to fully understand its potential benefits and applications.

 How is  Combretum Extract manufactured by MEDIOCON INC Synthesized?

Combretum extract synthesis involves various methods:

Extraction Methods

1. Solvent extraction: Using solvents like ethanol or methanol to extract bioactive compounds.

2. Water extraction: Using water as a solvent to extract water-soluble compounds.

3. Cold pressing: Mechanical extraction of compounds from plant material.

Purification Methods

1. Filtration: Removing impurities and particulate matter.

2. Chromatography: Separating and purifying bioactive compounds.

Standardization

1. Analytical techniques: Using methods like HPLC or GC to quantify bioactive compounds.

2. Standardization: Ensuring consistent levels of bioactive compounds.

The synthesis method may vary depending on the desired extract properties, plant material, and intended application.

What are the different  dosage forms  of   Combretum Extract Manufactured  by  MEDIOCON INC?

Combretum extract comes in various dosage forms, including¹ ² ³:

- Powder: Available in extract powder form, often standardized to specific ratios like 10:1 or 25X.

- Tea: Can be prepared as a hot water infusion, with recommended dosages of 0.5 to 1 gram of extract or 20-30 grams of leaves per liter of water.

- Tincture: Available in ethanolic tincture form, with recommended dosages of 50 drops, 2-4 times a day.

- Raw Leaves: Can be chewed or eaten raw, with the option to turn them into powder for easier consumption.

 

Some specific products include⁴:

- Combretum Quadrangulare 25X Extract: A potent extract powder with energizing and relaxing properties.

- Combretum Quadrangulare (Sakae Naa) Extract Powder 10:1: A concentrated powder extract with mood-enhancing and pain-relieving properties.

When using Combretum extract, it's essential to follow recommended dosages and consult with a healthcare professional, especially if you're pregnant, breastfeeding, or taking medications

 How Combretum Extract Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Combretum extract dosage forms are prepared using various methods depending on the desired form. Here's an overview of the preparation process for different dosage forms:

 

Liquid Dosage Forms

- Decoctions: Prepared by boiling crude plant material in water for a specific time, then cooling and filtering the extract. Dosage: 3-4 times a day, up to 500 ml per day.

- Infusions: Made by using cold or hot water for herbal extraction, resulting in dilute solutions. Dosage: 3-4 times a day, up to 500 ml per day.

- Tinctures: Prepared by extracting herbal materials with ethanol or a hydroalcoholic solution (1 part herb to 5-10 parts ethanol). Dosage: 5 ml diluted to 25 ml, 2-3 times a day.

- Syrups: Viscous liquids containing high amounts of sugars or sweetening agents, with or without medicine and flavoring agents. Dosage: 1-2 teaspoonfuls thrice a day.

 

Solid Dosage Forms

- Tablets: Prepared according to European Pharmacopeia guidelines, ensuring correct dosage and pharmacological quality. Combretum micranthum tablets are available in 200 mg strength.

- Capsules: Containing herbal extracts or oils, capsules are solid dosage forms that release medication slowly. Examples include Fenugreek capsules and Chlorella capsules.

- Granules: Prepared by drying or freeze-drying decoctions, granules can be packaged in sachets or capsules. Dosage: 2 g of granules, three times daily.

 

Other Dosage Forms

- Ointments: Semisolid preparations applied topically, often containing herbal extracts. Examples include Calendula ointment and Herboheal ointment.

- Creams: Semisolid dosage forms containing herbs in a hydrophilic base, with a relatively short shelf life. Examples include herbal fairness creams and baby creams.

- Pills: Spherical dosage forms made from herbal extracts, larger than granules. Examples include Madhunashinivati and Chandraprabhavati

What are the appropriate Dosage forms of Combretum Extract Manufactured  by  MEDIOCON   INC?                

The appropriate dosage forms of Combretum extract depend on the intended use and desired benefits. Some common dosage forms include:

Oral Dosage Forms

1. Capsules: Containing Combretum extract powder or oil.

2. Tablets: Compressed tablets containing Combretum extract.

3. Powder: Loose powder or sachets containing Combretum extract.

Liquid Dosage Forms

1. Tinctures: Liquid extracts of Combretum using solvents like ethanol.

2. Teas: Infusions or decoctions of Combretum leaves or bark.

Topical Dosage Forms

1. Creams: Topical creams containing Combretum extract for skin application.

2. Ointments: Semisolid preparations containing Combretum extract for wound healing or skin conditions.

The choice of dosage form depends on factors like bioavailability, patient compliance, and therapeutic goals. Consult a healthcare professional for specific guidance on using Combretum extract.

When should Combretum Extract Manufactured by MEDIOCON INC be taken?

The timing of taking Combretum extract depends on the specific product and intended use. Here are some general guidelines:

Dosage Timing

1. With meals: Taking Combretum extract with meals may help reduce gastrointestinal side effects.

2. As directed: Follow the product label or healthcare provider's instructions for specific dosage timing.

Considerations

1. Individual needs: Consult a healthcare provider for personalized guidance on taking Combretum extract.

2. Product specifications: Check the product label for recommended dosage and timing.

It's essential to consult with a healthcare provider before taking Combretum extract, especially if you have underlying health conditions or take medications.

 What are the effects And Side effects of Combretum Extract Manufactured by MEDIOCON INC?

Combretum extract has various potential effects and side effects, depending on the specific type and usage.

 

Potential Effects:

 

- Antioxidant and Anti-Inflammatory Properties: May help protect against oxidative stress and inflammation.

- Liver Health and Detox: Traditionally used to support liver function and aid digestion.

- Blood Sugar Management: May help manage blood sugar levels.

- Skin Conditioning: Can help soften and smooth skin, reducing redness and irritation.

Potential Side Effects:

- Topical Use:

    - Mild skin irritation, fleeting stinging, or redness, especially on dry or compromised skin.

    - Allergic contact dermatitis (itching or rash) in individuals sensitive to the Combretaceae family.

- Oral Consumption:

    - Stomach pain, potentially due to high doses or individual sensitivity.

    - Weight loss, insomnia, and skin darkening (particularly on the cheeks) with high doses or long-term use of certain Combretum species like Combretum quadrangulare.

    - Potential interactions with medications, such as diabetes medications, blood thinners, and diuretics, which may require monitoring blood sugar levels and blood pressure closely.¹ ² ³

Precautions:

- Pregnancy and Breastfeeding: Limited information available; consult a healthcare professional before use.

- Interactions with Medications: Potential interactions with various medications, including diabetes medications, blood thinners, and diuretics.

  How is Combretum Extract Manufactured by MEDIOCON  INC  Tested Qualitatively?

Combretum extract is tested qualitatively using various analytical techniques:

Chemical Testing

1. High-Performance Liquid Chromatography (HPLC): Detects and quantifies bioactive compounds.

2. Gas Chromatography (GC): Analyzes volatile compounds.

Spectroscopic Analysis

1. Mass Spectrometry (MS): Identifies molecular structure and composition.

2. Nuclear Magnetic Resonance (NMR) Spectroscopy: Determines molecular structure.

Phytochemical Screening

1. Phytochemical tests: Detects presence of alkaloids, flavonoids, phenols, and other compounds.

Quality Control

1. Standardization: Ensures consistent levels of bioactive compounds.

2. Purity testing: Detects contaminants and adulterants.

These tests ensure the quality, safety, and efficacy of Combretum extract.

   Which tests are performed on Combretum Extract Manufactured by  MEDIOCON INC ?

Combretum extract undergoes various tests to ensure quality, safety, and efficacy. Some common tests include:

Physical Tests

1. Appearance: Visual inspection of color, texture, and consistency.

2. Solubility: Determines solubility in various solvents.

Chemical Tests

1. HPLC (High-Performance Liquid Chromatography): Detects and quantifies bioactive compounds.

2. GC (Gas Chromatography): Analyzes volatile compounds.

3. Phytochemical screening: Detects presence of alkaloids, flavonoids, phenols, and other compounds.

Microbiological Tests

1. Microbial enumeration: Detects presence of microorganisms (e.g., bacteria, yeast, mold).

2. Pathogen testing: Ensures absence of pathogens (e.g., E. coli, Salmonella).

Quality Control Tests

1. Standardization: Ensures consistent levels of bioactive compounds.

2. Purity testing: Detects contaminants and adulterants.

3. Heavy metal testing: Ensures absence of heavy metals.

These tests help ensure the quality, safety, and efficacy of Combretum extract.

What are the challenges in Manufacturing of Combretum Extract Manufactured by MEDIOCON   INC API?

- Regulatory Compliance: Keeping up with constantly changing regulations is crucial to avoid legal issues and maintain production integrity. Establishing a robust compliance framework and staying updated with current regulations can help.

- Complex Processes: API manufacturing involves complex chemical processes, requiring specialized equipment and expertise. Scaling up production while maintaining process consistency and product quality can be particularly challenging.

- Quality Control: Ensuring the quality and consistency of the extract is vital. This involves implementing robust quality control measures, such as standardizing bioactive compounds and detecting contaminants.

- Supply Chain Management: Managing relationships with external partners, such as suppliers and contractors, is essential for smooth operations. Clear communication protocols and regular meetings can help address issues quickly.

- Cost Competitiveness: API manufacturers face pricing pressure, making it essential to balance costs with quality and regulatory compliance.

- Scaling Up Production: Transitioning from small-scale to large-scale production can introduce unexpected obstacles, such as new impurities or increased batch-to-batch variability. Close monitoring and process optimization are necessary to overcome these challenges.

- Risk Management: Identifying, assessing, and controlling risks is critical to ensuring product quality and safety. This includes implementing risk management strategies for potential issues like contamination or supply chain disruptions.

- Employee Training: Providing comprehensive training programs for employees is vital to maintain high standards of production and compliance.

- Technological Integration: Leveraging technologies like real-time monitoring, automation, and advanced analytics can help optimize production processes and improve efficiency.

What are the challenges in manufacturing of Combretum Extract Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Combretum extract dosage forms poses several challenges, including:

 

Formulation Challenges

 

- Standardization and Quality Control: Ensuring consistency in the quality and potency of herbal formulations is challenging due to natural variations in plant constituents.

- Bioavailability and Stability: Optimizing formulations for bioavailability and stability can be difficult, especially when combining multiple herbal ingredients.

Manufacturing Challenges

- Raw Material Sourcing: Ensuring a sustainable and reliable supply of raw materials is crucial, as overharvesting and environmental impact from cultivation practices can affect the long-term viability of certain plant species.

- Process Monitoring and Control: Implementing a comprehensive process monitoring system is essential to track critical parameters and ensure product quality.

- Equipment and Facility Design: Designing facilities and equipment that meet specific requirements for herbal drug processing is vital.¹

Regulatory Challenges

- Regulatory Compliance: Navigating complex and evolving regulatory frameworks for herbal products can be challenging, especially across different countries.

- Documentation and Labeling: Meeting documentation requirements, safety standards, and labeling regulations is essential.

Other Challenges

- Scientific Validation: Conducting rigorous scientific validation of efficacy and safety can be difficult, especially for traditional herbal formulations.

- Technological Integration: Adopting advanced technologies like nanotechnology for drug delivery or innovative extraction methods may face resistance or slow adoption.

- Environmental Sustainability: Ensuring sustainable sourcing and production practices is crucial to minimize environmental impact

What is the Packing for Combretum Extract Manufactured by MEDIOCON INC?

Combretum extract is typically packaged in plastic containers, with options for different solvents such as¹:

- Pentylene Glycol: 1 kg packaging available

- Propylene Glycol: 1 kg packaging available

- Glycerin: 1 kg packaging available

The product is usually shipped depending on customer status, and storage is recommended in a dry place between 10-30°C in the originally sealed container. Industrial container sizes and price scales may also be available upon request.

What is shelf life Of Combretum Extract Manufactured by MEDIOCON INC? 

The shelf life of Combretum extract varies depending on storage conditions and packaging. Generally:

- Best if used within: 2 years from manufacturing date.

- Storage conditions: Cool, dry place, away from direct sunlight and moisture.

- Packaging: Airtight containers or sealed packaging to maintain quality.

 

Proper storage and handling can help extend shelf life. Check product labels or consult manufacturers for specific guidance.

What should the label claim for Combretum Extract Manufactured by MEDIOCON INC   Include?

The label claim for Combretum extract should include:

- Product Name: Scientific name (e.g., Combretum micranthum) and common name.

- Active Ingredients: List of bioactive compounds (e.g., flavonoids, phenolic acids).

- Concentration: Percentage or amount of extract per serving.

- Dosage Instructions: Recommended dosage and usage guidelines.

- Storage Conditions: Instructions for storage (e.g., cool, dry place).

- Expiration Date: Shelf life or expiration date.

- Manufacturer Information: Name and contact details of the manufacturer.

- Regulatory Compliance: Compliance with relevant regulatory standards (e.g., GMP, ISO).

- Cautionary Statements: Any necessary warnings or cautions (e.g., pregnancy, breastfeeding, interactions with medications).

 

Ensure label claims are accurate, compliant with regulations, and supported by scientific evidence.

Where can Combretum Extract Manufactured by MEDIOCON INC are procured?

Combretum Extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Combretum Extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Combretum Extract Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Combretum Extract Manufactured by MEDIOCON INC product, regardless of the procurement source.