Red Vine Leaf Extract 84929-27-1 Manufacturer Exporter MEDIOCON INC

 

 

Red Vine Leaf Extract Manufactured by MEDIOCON INC     

 

   Name: Red Vine Leaf Extract

CAS No:  84929-27-1

Molecular Weight:  NA

Molecular formula:   NA

Synonyms:  Vitis vinifera L. extract, Vitis viniferae folium extract.

Appearance:  Reddish or brownish color dry powder or Liquid.

 Solubility :   Partially soluble, with solubility increasing in hot water, Soluble, especially in aqueous ethanol solutions, Soluble in glycerine often used in liquid formulations.

Use :

Red vine leaf extract is used for:

Health Benefits1. Chronic Venous Insufficiency (CVI): Relieves symptoms like leg swelling, pain, and heaviness.

2. Varicose Veins: Helps reduce appearance and alleviate discomfort.

3. Hemorrhoids: May help reduce symptoms like pain and swelling.

Other Uses1. Antioxidant Properties: Protects against oxidative stress and cell damage.

2. Anti-Inflammatory Effects: May help reduce inflammation and improve circulation.

Forms1. Dietary Supplements: Capsules, tablets, or powders.

2. Topical Preparations: Creams, gels, or ointments for local application.

Precautions1. Consult a Healthcare Professional: Before using red vine leaf extract, especially if pregnant, breastfeeding, or taking medications.

Red vine leaf extract's potential benefits make it a popular ingredient in natural remedies and supplements.

 How is  Red Vine Leaf Extract manufactured by MEDIOCON INC Synthesized?

Red vine leaf extract is synthesized through various extraction methods, including:

Conventional Methods1. Maceration: Soaking grape leaves in a solvent (e.g., water, ethanol) to extract bioactive compounds.

2. Soxhlet Extraction: Continuous extraction using a solvent (e.g., ethanol, methanol).

3. Reflux Extraction: Heating grape leaves in a solvent (e.g., methanol-water mixture) to extract polyphenols.

Advanced Methods1. Ultrasound-Assisted Extraction (UAE): Using high-frequency sound waves to enhance extraction efficiency.

2. Microwave-Assisted Extraction (MAE): Utilizing microwave energy to accelerate extraction.

3. Supercritical Fluid Extraction (SFE): Employing high-pressure carbon dioxide to extract bioactive compounds.

Key Considerations1. Solvent selection: Choosing the right solvent (e.g., water, ethanol, methanol) for optimal extraction.

2. Optimization: Adjusting extraction conditions (e.g., temperature, time, solvent-to-solid ratio) for maximum yield and quality.

These methods aim to extract valuable compounds like polyphenols, flavonoids, and anthocyanins from red vine leaves.

What are the different  dosage forms  of   Red Vine Leaf Extract Manufactured  by  MEDIOCON INC?

Red vine leaf extract is available in various dosage forms, including:

Oral Dosage Forms1. Tablets: Containing dried red vine leaf extract (e.g., 360mg).

2. Capsules: Containing red vine leaf extract in various strengths.

3. Liquid Extracts: Concentrated liquid forms for oral administration.

Topical Dosage Forms1. Creams: Topical creams for local application.

2. Gels: Gel formulations for skin application.

3. Ointments: Semi-solid preparations for topical use.

Other Forms1. Tea: Dried red vine leaves can be used to make tea.

2. Powders: Red vine leaf extract powders for dietary supplements.

 

These dosage forms cater to different needs and preferences, offering flexibility in using red vine leaf extract for its potential health benefits.

 How Red Vine Leaf Extract Manufactured by MEDIOCON INC   Dosage Forms are prepared?

The preparation of Red Vine Leaf Extract dosage forms involves several steps:

Oral Dosage Forms (Tablets, Capsules)1. Extraction: Red vine leaf extract is obtained through various extraction methods (e.g., solvent extraction, aqueous extraction).

2. Concentration: The extract is concentrated through techniques like evaporation or lyophilization.

3. Drying: The concentrated extract is dried to obtain a powder.

4. Formulation: The powder is mixed with excipients (e.g., binders, fillers) and formulated into tablets or capsules.

Topical Dosage Forms (Creams, Gels, Ointments)1. Extraction: Red vine leaf extract is obtained through suitable extraction methods.

2. Concentration: The extract is concentrated and mixed with a suitable base (e.g., cream, gel, ointment).

3. Formulation: The extract is incorporated into the topical formulation, ensuring uniform distribution.

General Steps1. Quality Control: Raw materials and finished products undergo quality control tests.

2. Standardization: Extracts are standardized to ensure consistent levels of active compounds.

3. Packaging: Finished products are packaged in suitable containers (e.g., bottles, tubes).

The specific preparation process may vary depending on the manufacturer and the desired dosage form.

What are the appropriate Dosage forms of Red Vine Leaf Extract Manufactured  by  MEDIOCON   INC?                

Red Vine Leaf Extract is available in various dosage forms, including¹ ² ³:

- Tablets: 360mg of Red Vine Leaf Extract, taken once daily.

- Capsules: Containing dried red vine leaf extract (270-350mg), taken 3-5 times a day or 360-720mg per day.

- Herbal Tea: 5-10g of dried leaves in 250ml of boiling water, taken twice a day.

- Creams: Topical application, one to three times a day, for relief from varicose veins and hemorrhoids.

- Dried Extract: 4-6:1 dry extract, 360-720mg per day.

 

The recommended dosage may vary depending on the specific product and individual needs. It's essential to consult with a healthcare professional before starting any supplement regimen.

When should Red Vine Leaf Extract Manufactured by MEDIOCON INC be taken?

Red Vine Leaf Extract can be taken:

Timing1. With meals: To minimize stomach upset.

2. Consistently: At the same time each day to maintain steady levels.

Frequency1. Once daily: For general health benefits.

2. Multiple times a day: As directed by a healthcare professional or product label.

Considerations1. Consult a healthcare professional: Before starting supplementation, especially if pregnant, breastfeeding, or taking medications.

2. Follow product label instructions: Adhere to recommended dosages and guidelines.

Individual needs may vary, and it's essential to consult with a healthcare professional for personalized advice.

 What are the effects And Side effects of Red Vine Leaf Extract Manufactured by MEDIOCON INC?

Red Vine Leaf Extract has several potential effects and side effects:

Potential Effects1. Improves circulation: Helps alleviate symptoms of chronic venous insufficiency (CVI).

2. Reduces swelling: May decrease leg swelling and pain.

3. Antioxidant properties: Protects against oxidative stress.

Potential Side Effects1. Gastrointestinal issues: Nausea, stomach upset, or diarrhea.

2. Allergic reactions: Rare cases of allergic reactions, such as skin rashes or itching.

Interactions1. Blood thinners: May interact with anticoagulant medications.

2. Other medications: Consult a healthcare professional before combining with other medications.

Precautions1. Pregnancy and breastfeeding: Consult a healthcare professional before using.

2. Bleeding disorders: Use with caution if you have bleeding disorders.

It's essential to consult with a healthcare professional before taking Red Vine Leaf Extract, especially if you have underlying medical conditions or take medications.

  How is Red Vine Leaf Extract Manufactured by MEDIOCON  INC  Tested Qualitatively?

Red Vine Leaf Extract is tested qualitatively using various methods to identify and characterize its bioactive compounds:

Analytical Techniques1. High-Performance Liquid Chromatography (HPLC): Separates and detects flavonoids, phenolic acids, and other compounds.

2. Gas Chromatography-Mass Spectrometry (GC-MS): Identifies volatile compounds and metabolites.

3. Liquid Chromatography-Mass Spectrometry (LC-MS): Analyzes complex mixtures and detects specific biomarkers.

4. Spectroscopy: Techniques like UV-Vis spectroscopy or infrared spectroscopy help identify functional groups.

Qualitative Analysis1. Fingerprinting: Creates a unique chromatographic profile to identify specific compounds.

2. Marker compounds: Identifies specific flavonoids or phenolic acids as markers for quality control.

Quality Control1. Purity testing: Verifies the absence of contaminants and adulterants.

2. Standardization: Ensures consistent levels of bioactive compounds.

   Which tests are performed on Red Vine Leaf Extract Manufactured by  MEDIOCON INC ?

Red Vine Leaf Extract undergoes various tests to ensure its quality, efficacy, and safety. Some of the key tests include¹ ² ³:

- Phytochemical Analysis: Evaluating the presence and concentration of bioactive compounds like flavonoids (quercetin, kaempferol), anthocyanins, and proanthocyanidins.

- High-Performance Liquid Chromatography (HPLC): Identifying and quantifying specific compounds like quercetin-3-O-β-D-glucuronide and isoquercitrin.

- Spectroscopy: Techniques like UV-Vis spectroscopy or infrared spectroscopy help identify functional groups.

- Microbiological Testing: Assessing the presence of microorganisms and ensuring the extract's safety.

- Heavy Metal Testing: Detecting the presence of heavy metals and ensuring compliance with regulatory limits.

- Purity Testing: Verifying the absence of contaminants and adulterants.

- Standardization: Ensuring consistent levels of bioactive compounds, such as polyphenols (≥ 30%) and anthocyanins (≥ 0.3%).

- Clinical Trials: Evaluating the extract's efficacy in treating conditions like chronic venous insufficiency, varicose veins, and hemorrhoids.

These tests help ensure the quality and efficacy of Red Vine Leaf Extract, which is used to support vein health, improve microcirculation, and alleviate symptoms associated with venous insufficiency.

What are the challenges in Manufacturing of Red Vine Leaf Extract Manufactured by MEDIOCON   INC API?

The manufacturing of Red Vine Leaf Extract API faces several challenges, including:

- Quality Control: Ensuring consistent quality and composition of the extract is crucial. Variations in component content can impact efficacy and safety.

- Standardization: Standardizing the extract to ensure consistent levels of bioactive compounds, such as flavonoids and stilbenes, is essential.

- Raw Material Variability: Differences in grapevine cultivars, growing conditions, and harvesting methods can affect the quality and composition of the extract.

- Manufacturing Process: The extraction process, including solvent selection and optimization, can significantly impact the quality and yield of the final product.

- Regulatory Compliance: Meeting regulatory requirements and ensuring compliance with Good Manufacturing Practices (GMP) is vital.

- Consistency: Ensuring batch-to-batch consistency and product-to-product consistency is crucial for efficacy and safety.

- Additives and Contaminants: Controlling additives and contaminants, such as sugars and other substances, is essential to prevent adverse effects on the final product.

 

To overcome these challenges, manufacturers can implement robust quality control measures, optimize extraction processes, and ensure compliance with regulatory requirements.

What are the challenges in manufacturing of Red Vine Leaf Extract Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Red Vine Leaf Extract dosage forms poses several challenges, including:

- Raw Material Variability: Differences in grapevine cultivars, growing conditions, and harvesting methods can affect the quality and composition of the extract.

- Standardization: Ensuring consistent levels of bioactive compounds, such as flavonoids and stilbenes, is crucial for efficacy and safety.

- Formulation: Developing a suitable formulation that ensures high bioavailability and stability of the extract can be challenging.

- Tablet Stability: Ensuring the tablet's stability and preventing degradation of the extract over time is essential.

- Patient Compliance: The dosage form should be easy to swallow and administer, making patient compliance a key consideration.

- Regulatory Compliance: Meeting regulatory requirements and ensuring compliance with Good Manufacturing Practices (GMP) is vital.

Some specific challenges in tablet formulation include¹:

- Compression Forces: Finding the optimal compression force to produce tablets with suitable breaking resistance and breakdown times.

- Excipient Selection: Choosing the right excipients, such as binders, disintegrants, fillers, and lubricants, to ensure the tablet's stability and bioavailability.

- Flow Regulator: Adding flow regulators like colloidal anhydrous silica to improve the extract's flow properties and prevent caking.

To overcome these challenges, manufacturers can implement robust quality control measures, optimize extraction processes, and ensure compliance with regulatory requirements.

What is the Packing for Red Vine Leaf Extract Manufactured by MEDIOCON INC?

Red Vine Leaf Extract packaging varies depending on the manufacturer and product specifications. Here are some common packing options¹ ² ³:

- 1kg/bag: Packed in an aluminum foil bag inside a paper carton, suitable for bulk purchases.

- 25kg/drum: Packed in a cardboard drum with two plastic bags inside, ideal for large-scale manufacturing.

- Tablets/Bottles: Available in bottles of 30 tablets, each containing 360mg of Red Vine Leaf Extract, designed for individual use.

- Capsules: Offered in packs of 60 vegetarian capsules, combining Red Vine Leaf Extract with Horse Chestnut Extract for enhanced benefits.

 

When selecting a product, consider the packaging, storage conditions, and manufacturer's reputation to ensure quality and efficacy. Always check the product label for specific details on packaging, dosage, and storage instructions.

What is shelf life Of Red Vine Leaf Extract Manufactured by MEDIOCON INC? 

The shelf life of Red Vine Leaf Extract varies depending on storage conditions and product specifications. Generally, it can last:

- 24 months: When stored properly in a cool, dry place, away from direct sunlight and heat.

- 36 months: Some products have a longer shelf life, up to 3 years, if stored according to the manufacturer's instructions.

 

To maximize the shelf life, it's essential to:

- Store in a cool, dry place: Avoid exposure to heat, moisture, and direct sunlight.

- Keep away from toxic and hazardous materials: Ensure the storage area is safe and secure.

- Follow manufacturer's instructions: Check the product label for specific storage and handling guidelines.

Proper storage and handling can help maintain the extract's quality and potency throughout its shelf life.

What should the label claim for Red Vine Leaf Extract Manufactured by MEDIOCON INC   Include?

The label claim for Red Vine Leaf Extract should include:

- Product Name: Red Vine Leaf Extract or specific brand name.

- Active Ingredients: List of bioactive compounds, such as flavonoids (e.g., quercetin) and anthocyanins.

- Concentration: Specification of extract ratio (e.g., 4:1 or 360mg per serving).

- Recommended Dosage: Clear instructions on daily intake.

- Indications: Claims related to vein health, circulation, or specific benefits (e.g., "supports healthy blood flow").

- Warnings and Precautions: Any relevant warnings, such as interactions with medications or contraindications.

- Storage Instructions: Guidance on proper storage conditions.

- Manufacturer Information: Name and contact details of the manufacturer or distributor.

- Batch Number and Expiry Date: Essential for quality control and tracking.

- Certifications: Any relevant certifications, such as GMP or third-party testing.

Where can Red Vine Leaf Extract Manufactured by MEDIOCON INC are procured?

Red Vine Leaf Extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Red Vine Leaf Extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Red Vine Leaf Extract Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Red Vine Leaf Extract Manufactured by MEDIOCON INC product, regardless of the procurement source.