Senna leaf Extract 85187-05-9 Manufacturer Exporter MEDIOCON INC

 

 

Senna leaf Extract  Manufactured by MEDIOCON INC     

 

   Name: Senna leaf Extract

   CAS No: 85187-05-9

Molecular Weight:  862.75 g/mol

Molecular formula:   NA

Synonyms:  Alexandrian senna and Tinnevelly senna, and Sanskrit names such as Swarnapatri and Markandika.

Appearance:  dark green or brown liquid or a yellow-brown to brown powder.

 Solubility :   water-soluble.

Use :

Senna leaf extract is a natural laxative used to treat constipation, promote digestive health, and prepare the bowel for medical procedures like colonoscopies. Here are some of its key uses:

 

- Relieving Constipation: Senna leaf extract stimulates bowel movements and helps ease constipation by irritating the intestinal lining, promoting peristalsis, and increasing water secretion in the intestines.

- Bowel Preparation: Senna is used to cleanse the colon before diagnostic tests, ensuring a clear view of the intestinal lining.

- Hemorrhoid Relief: Senna leaf extract may help soften stools and facilitate bowel movements, reducing strain and discomfort associated with hemorrhoids.

- Detoxification: Some people use senna leaf extract as part of detox programs to cleanse the digestive tract and remove waste and toxins.

- Weight Loss: While senna can lead to temporary weight loss due to water loss, it's not a recommended long-term weight loss strategy.

 

Important Considerations:

 

- Dosage: Follow recommended dosages, typically 15-100 mg per day for adults, and consult a healthcare professional before use.

- Duration: Limit use to 1-2 weeks, as prolonged use can lead to dependence on laxatives and electrolyte imbalances.

- Side Effects: Common side effects include nausea, vomiting, abdominal cramps, and diarrhea.

- Contraindications: Avoid using senna if you have gastrointestinal obstruction, severe fecal impaction, or certain medical conditions, such as inflammatory bowel disease or heart disease.¹ ²

Precautions:

- Consult a healthcare professional before using senna leaf extract, especially if you're pregnant, breastfeeding, or have underlying medical conditions.

- Monitor your body's response and adjust your dosage or discontinue use if you experience adverse effects.

- Stay hydrated to minimize potential side effects like dehydration.

 How is  Senna leaf Extract  manufactured by MEDIOCON INC Synthesized?

Senna leaf extract is synthesized through various extraction methods, including:

Extraction Methods

1. Solvent extraction: Using solvents like ethanol or methanol to extract bioactive compounds.

2. Water extraction: Using hot water to extract sennosides and other water-soluble compounds.

3. Hydro-alcoholic extraction: Combining water and ethanol to extract a broader range of compounds.

Processing Steps

1. Drying: Drying senna leaves to preserve bioactive compounds.

2. Grinding: Grinding dried leaves into a fine powder.

3. Extraction: Applying extraction methods to obtain the desired extract.

4. Filtration: Filtering the extract to remove impurities.

5. Concentration: Concentrating the extract through evaporation or other methods.

Quality Control

1. Standardization: Standardizing the extract to specific levels of sennosides.

2. Testing: Testing for purity, potency, and contaminants.

The specific synthesis method may vary depending on the desired extract type, intended use, and manufacturer.

What are the different  dosage forms  of   Senna leaf Extract  Manufactured  by  MEDIOCON INC?

Senna leaf extract is available in various dosage forms, including:

- Tablets: 8.6 mg, 15 mg, 17 mg, 17.2 mg, and 25 mg of sennosides

- Chewable Tablets: 10 mg and 15 mg of sennosides, with some flavors like chocolate

- Liquid: 8.8 mg/5 mL and 33.3 mg/mL of senna leaf extract or sennosides

- Concentrated Oral Drops: 8.8 mg/mL of sennosides

- Syrup: 8.8 mg/5 mL and 176 mg/5 mL of senna leaf extract or sennosides

- Senna Leaves: 454g, often used to make tea

- Leaf Extract: 176 mg/5 mL, considered a dietary supplement

These dosage forms are used to treat constipation and prepare the bowel for medical procedures like colonoscopy. The dosage and administration may vary depending on age, medical condition, and product formulation.

 How Senna leaf Extract  Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Senna leaf extract dosage forms are prepared in various ways to treat constipation and prepare the bowel for medical procedures. Here are some common dosage forms and their preparation methods:

- Tablets: Senna leaf extract is compressed into tablets with specific strengths, such as 8.6 mg, 15 mg, or 25 mg of sennosides. These tablets are designed to be taken orally, usually at bedtime, with a full glass of water.

- Liquid Extracts: Liquid extracts are prepared by dissolving senna leaf extract in a solvent, such as water or ethanol. The concentration of sennosides can vary, but common strengths include 8.8 mg/5 mL or 176 mg/5 mL.

- Syrups: Syrups are liquid preparations that contain senna leaf extract, often with added flavorings and sweeteners. They are typically administered orally, with dosages measured in milliliters.

- Chewable Tablets: Chewable tablets contain senna leaf extract in a flavored base, allowing patients to chew the tablet before swallowing.

- Tea Infusions: Tea infusions are prepared by steeping dried senna leaves or fruits in hot water. The resulting liquid is then strained and consumed orally.

To ensure quality and consistency, senna leaf extract dosage forms are often standardized to contain specific amounts of sennosides. The preparation of these dosage forms involves¹ ² ³:

- Standardization: Ensuring the extract contains a consistent amount of sennosides.

- Quality Control: Testing for purity, potency, and contaminants.

- Formulation: Combining the extract with other ingredients, such as fillers, binders, or flavorings, to create the desired dosage form.

It's essential to follow the recommended dosage and preparation instructions for each specific product to ensure safe and effective use.

What are the appropriate Dosage forms of Senna leaf Extract  Manufactured  by  MEDIOCON   INC?                

Appropriate dosage forms of Senna leaf Extract include:

Dosage Forms

1. Tablets: 8.6 mg, 15 mg, or 25 mg of sennosides.

2. Liquid extracts: 8.8 mg/5 mL or 176 mg/5 mL of senna leaf extract.

3. Syrups: 8.8 mg/5 mL or 176 mg/5 mL of senna leaf extract.

4. Chewable tablets: 10 mg or 15 mg of sennosides.

Considerations

1. Standardization: Ensure the extract is standardized to specific levels of sennosides.

2. Dosage: Follow recommended dosages, typically 15-100 mg of sennosides per day.

3. Duration: Limit use to 1-2 weeks, as prolonged use can lead to dependence.

Product Selection

1. Look for third-party certifications: Ensure the product meets quality standards.

2. Choose products from reputable manufacturers: Ensure the product is safe and effective.

3. Check the label: Verify the product's ingredients, dosage, and instructions.

The appropriate dosage form and amount may vary depending on individual needs and health status. Consult a healthcare professional for personalized guidance.

When should Senna leaf Extract  Manufactured by MEDIOCON INC be taken?

Senna leaf extract is typically taken:

Timing

1. At bedtime: To promote a bowel movement in the morning.

2. As directed: Follow the recommended dosage and timing instructions provided by a healthcare professional or the product label.

Considerations

1. Short-term use: Senna leaf extract is generally recommended for short-term use (1-2 weeks) to avoid dependence.

2. Individual needs: Consult a healthcare professional to determine the best timing and dosage for your specific needs.

Precautions

1. Pregnancy and breastfeeding: Consult a healthcare professional before using senna leaf extract.

2. Underlying medical conditions: Consult a healthcare professional if you have underlying medical conditions, such as gastrointestinal disorders.

Taking senna leaf extract as directed can help promote regular bowel movements and relieve constipation.

 What are the effects And Side effects of Senna leaf Extract  Manufactured by MEDIOCON INC?

Senna leaf extract has various effects and potential side effects:

Effects

1. Laxative properties: Stimulates bowel movements and relieves constipation.

2. Digestive cleansing: Helps cleanse the colon and promote regularity.

Side Effects

1. Abdominal cramps: Can cause stomach discomfort and cramping.

2. Diarrhea: May lead to loose stools or diarrhea.

3. Dependence: Prolonged use can lead to dependence on laxatives.

4. Electrolyte imbalance: May cause electrolyte imbalances, particularly potassium.

Precautions

1. Short-term use: Recommended for short-term use (1-2 weeks) to avoid dependence.

2. Pregnancy and breastfeeding: Consult a healthcare professional before using senna leaf extract.

3. Underlying medical conditions: Consult a healthcare professional if you have underlying medical conditions, such as gastrointestinal disorders.

Interactions

1. Medications: May interact with certain medications, such as diuretics, and affect their efficacy or increase the risk of side effects.

It's essential to use senna leaf extract responsibly and under the guidance of a healthcare professional if necessary.

  How is Senna leaf Extract  Manufactured by MEDIOCON  INC  Tested Qualitatively?

Senna leaf extract is tested qualitatively using various methods to ensure its quality, purity, and potency. Here are some common testing methods:

Chemical Testing

1. High-Performance Liquid Chromatography (HPLC): Analyzes the presence and concentration of sennosides and other bioactive compounds.

2. Thin-Layer Chromatography (TLC): Identifies the presence of sennosides and other compounds.

Physical Testing

1. Appearance: Evaluates the extract's color, texture, and consistency.

2. Solubility: Tests the extract's solubility in various solvents.

Microbiological Testing

1. Microbial contamination: Tests for the presence of microorganisms, such as bacteria, yeast, and mold.

Standardization

1. Sennoside content: Standardizes the extract to specific levels of sennosides (e.g., sennoside A and B).

Other Tests

1. Heavy metal testing: Ensures the extract is free from heavy metal contaminants.

2. Pesticide residue testing: Tests for the presence of pesticide residues.

These testing methods help ensure the quality and safety of senna leaf extract for use in dietary supplements and pharmaceutical applications.

   Which tests are performed on Senna leaf Extract  Manufactured by  MEDIOCON INC ?

Senna leaf extract undergoes various tests to ensure its quality, purity, and potency. These tests include¹ ² ³:

- Phytochemical Analysis: Identifies and quantifies bioactive compounds like sennosides, alkaloids, saponins, tannins, flavonoids, triterpenoids, steroids and glycosides.

- High-Performance Liquid Chromatography (HPLC): Accurately determines concentrations of anthraquinone glycosides, such as sennoside A and B.

- Gas Chromatography-Mass Spectrometry (GC-MS): Combines chromatographic separation with mass spectrometry to identify compounds based on their mass-to-charge ratio.

- Thin-Layer Chromatography (TLC): Provides a rapid fingerprint profile of the extract's chemical constituents.

- Spectrophotometry: Measures the absorbance of light by sennosides to calculate their concentrations.

- Antimicrobial Activity Testing: Evaluates the extract's effectiveness against specific pathogens.

- Antioxidant Activity Testing: Assesses the extract's antioxidant properties using methods like the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.

- Phytochemical Screening: Identifies the presence of various phytochemicals, such as phenols, flavonoids and phytosterols.

- Quantitative Analysis: Determines the levels of specific compounds, like sennosides, flavonoids and phenolic content.

These tests help ensure the quality, efficacy and safety of senna leaf extract for use in dietary supplements and pharmaceutical applications.

What are the challenges in Manufacturing of Senna leaf Extract  Manufactured by MEDIOCON   INC API?

Manufacturing Senna leaf extract API poses several challenges, including¹ ²:

- Raw Material Quality: Ensuring high-quality senna leaves from reliable suppliers, free from contaminants like pesticides and heavy metals, is crucial.

- Extraction Method: Choosing the right extraction technique, such as solvent extraction or supercritical fluid extraction, and controlling parameters like temperature and pressure to optimize yield and quality.

- Solubility Issues: Senna leaf extract can have poor water solubility, which can be addressed through techniques like membrane filtration and plate-and-frame filter pressing.

- Impurities Removal: Removing impurities, such as polysaccharides, chlorophyll, and other unwanted compounds, to improve the purity and potency of the extract.

- Stability and Shelf Life: Ensuring the extract's stability and shelf life by controlling factors like storage conditions, packaging, and formulation.

- Regulatory Compliance: Meeting regulatory requirements and standards, such as GMP and ISO certifications, to ensure the product's quality and safety.

- Quality Control: Implementing robust quality control measures, including testing for active ingredients, microbial contamination, and heavy metals, to guarantee the product's quality and consistency.

- Scalability and Cost-Effectiveness: Scaling up production while maintaining cost-effectiveness without compromising quality is another significant challenge.

To overcome these challenges, manufacturers can adopt innovative solutions, such as³:

- Novel Formulations: Developing new formulations that enhance the extract's solubility, stability, and bioavailability.

- Sustainable Sourcing: Implementing sustainable sourcing practices to ensure the long-term availability of high-quality senna leaves.

- Advanced Extraction Techniques: Utilizing advanced extraction techniques, such as membrane filtration and supercritical fluid extraction, to improve efficiency and quality.

What are the challenges in manufacturing of Senna leaf Extract  Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Senna leaf extract dosage forms poses several challenges, including¹ ² ³:

- Raw Material Quality: Ensuring high-quality senna leaves from reliable suppliers, free from contaminants like pesticides and heavy metals, is crucial.

- Standardization: Standardizing the extract to specific levels of sennosides, the active compounds responsible for the laxative effect, is essential for efficacy and safety.

- Compound-Specific Isolation and Extraction: Isolating and extracting sennosides from senna leaves can be complex, requiring specialized techniques and equipment.

- Premature Release of Active Ingredient: Conventional tablet formulations may release the active ingredient too quickly, reducing efficacy. Developing enteric-coated tablets can help mitigate this issue.

- Regulatory Compliance: Meeting regulatory requirements and standards, such as GMP and HACCP, is necessary for product safety and efficacy.

- Stability and Shelf Life: Ensuring the stability and shelf life of senna leaf extract dosage forms is vital to maintain potency and safety.

- Potential Side Effects: Managing potential side effects like diarrhea, abdominal cramps, and dependence on laxatives is crucial.

- Limited Availability of High-Quality Raw Materials: Securing consistent supplies of high-quality senna leaves can be challenging.

- Competition from Synthetic Laxatives: The market competition from synthetic laxatives may impact the demand for natural senna leaf extract products.

To overcome these challenges, manufacturers can adopt innovative solutions, such as:

- Advanced Extraction Techniques: Utilizing advanced extraction methods to enhance yield and quality.

- Novel Formulations: Developing novel formulations that improve bioavailability, stability, and patient compliance.

- Sustainable Sourcing: Implementing sustainable sourcing practices to ensure long-term availability of high-quality senna leaves.

What is the Packing for Senna leaf Extract  Manufactured by MEDIOCON INC?

Senna leaf extract packing varies depending on the product and manufacturer. Here are some common packaging options:

- Tablets: Available in bottles or blister packs, with varying strengths such as 8.6 mg, 15 mg, 17 mg, and 25 mg of sennosides.

- Capsules: Some products come in capsule form, containing 150mg of senna leaf extract per serving, often in bottles of 90 or 200 capsules.

- Powder: Senna leaf extract powder is also available, packaged in drums, foil bags, or containers with 300g or 250g of product.

- Liquid Extracts: Some products are available as liquid extracts, often packaged in bottles with droppers or measuring cups.

Some examples of packaging include¹ ² ³:

- (link unavailable) Senna Leaf Extract: 8.8 oz (250g) bottle

- VEDIKA Senna leaf Extract Capsules: 90 capsules per pack

- Pure Senna Leaf Extract: 200 capsules per bottle

- Laxaquest Senna Leaf and Triphla Extract Tablets: 10-count packs available in various configurations (e.g., Pack of 2, Pack of 3, Pack of 5)

When storing senna leaf extract products, it's essential to follow the manufacturer's instructions and protect them from excessive heat and moisture.

What is shelf life Of Senna leaf Extract  Manufactured by MEDIOCON INC? 

The shelf life of Senna leaf extract is typically 2 years, provided it is stored properly in a cool, dry place, away from direct sunlight and moisture. It's essential to check the packaging for specific storage instructions and expiration dates to ensure the product's potency and safety.¹ ²

Storage Tips:

- Temperature: Store at room temperature, between 15°C to 30°C (59°F to 86°F).

- Humidity: Keep away from moisture.

- Light: Store in light-proof containers or away from direct sunlight.

- Packaging: Keep the product in its original container, tightly sealed.

Proper storage helps maintain the efficacy of Senna leaf extract and ensures it remains safe for consumption within its specified shelf life.

What should the label claim for Senna leaf Extract  Manufactured by MEDIOCON INC Include?

The label claim for Senna leaf extract should include the following information:

Essential Information

1. Product Name: Clearly state the product name, including the Latin name "Cassia senna" or "Senna alexandrina".

2. Active Ingredients: Specify the amount of sennosides per serving or dosage unit.

3. Dosage Instructions: Provide clear dosage instructions, including recommended daily intake and duration of use.

4. Warning Statements: Include warnings for potential side effects, such as abdominal cramps, diarrhea, and dependence on laxatives.

5. Contraindications: List contraindications, such as pregnancy, breastfeeding, and certain medical conditions (e.g., gastrointestinal disorders).

6. Storage Instructions: Provide storage instructions to maintain product potency and safety.

7. Expiration Date: Include the expiration date or shelf life.

Additional Information

1. Standardization: Specify the standardization method and level of sennosides.

2. Other Ingredients: List any other ingredients, such as fillers, binders, or excipients.

3. Manufacturer Information: Include the manufacturer's name, address, and contact information.

Regulatory Compliance

1. Regulatory Statements: Comply with relevant regulatory requirements, such as FDA or EU regulations.

2. Label Claims: Ensure label claims are accurate and substantiated by scientific evidence.

By including this information, the label claim for Senna leaf extract can provide consumers with essential information for safe and effective use.

Where can Senna leaf Extract  Manufactured by MEDIOCON INC are procured?

Senna leaf Extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Senna leaf Extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Senna leaf Extract Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Senna leaf Extract Manufactured by MEDIOCON INC product, regardless of the procurement source.